139 completed, 5 active not recruiting, 5 recruiting, 4 not yet recruiting. 162 Phase 1, 5 Phase 2.
Follow Digoxin: new trials by email Literature Review of Digoxin trials Research Report on Digoxin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants | Phase 1 | Recruiting | Basilea Pharmaceutica | 42 | 2026-10-01 | 2026-10-19 |
| An Open-label DDI Study to Investigate the Effect of Rilzabrutinib on P-gp, BCRP, OATP1B1 and OATP1B3 Inhibition Rilzabrutinib, Rosuvastatin, Digoxin - Healthy Volunteer | Phase 1 | Active not recruiting | Sanofi | 14 | 2026-10-01 | 2026-10-21 |
| A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy Adults Itraconazole, Rifampicin, Omeprazole - Healthy Subjects | Phase 1 | Not yet recruiting | InventisBio Co., Ltd | 60 | 2026-09-16 | 2026-10-15 |
| Drug-Drug Interaction Study of Atumelnant in Healthy Participants Atumelnant, Carbamazepine, Midazolam - Healthy Volunteers | Phase 1 | Completed | Crinetics Pharmaceuticals Inc. | 46 | 2026-05-28 | 2026-08-19 |
| Phase I Drug-Drug Interaction Study of UBT251 Injection in Participants With Overweight or Obesity UBT251, Metformin hydrochloride, Warfarin Sodium - Drug Drug Interaction (DDI), Pharmacokinetics and Pharmacodynamics | Phase 1 | Recruiting | The United Bio-Technology (Hengqin) Co., Ltd. | 48 | 2026-05-27 | 2026-08-25 |
| Drug-drug Interaction Study of ZT002 Injection in Overweight and Obese Participants ZT002 injection, metformin, warfarin, ZT002 injection, rosuvastatin, digoxin - Overweight,Obesity | Phase 1 | Active not recruiting | Beijing QL Biopharmaceutical Co.,Ltd | 60 | 2026-05-27 | 2026-10-21 |
| Drug-Drug Interactions of JMKX003142 in Healthy Participants JMKX003142 tablets, Fluconazole Capsules, Cocktail Substrates (Midazolam Oral Solution, Rosuvastatin Calcium Tablets, and Digoxin Tablets) - ADPKD (Autosomal Dominant Polycystic Kidney Disease) | Phase 1 | Not yet recruiting | Jemincare | 112 | 2026-05-11 | 2026-05-04 |
| A Phase 1 Study to Assess the Effect of ABBV-722 on Midazolam, Digoxin, Pitavastatin, Metformin, and Sitagliptin Drug Levels in Healthy Adults. ABBV-722, Midazolam, Metformin - Healthy Volunteers | Phase 1 | Completed | AbbVie | 12 | 2026-04-30 | 2026-08-20 |
| Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin Acetaminophen, Metformin, Warfarin - Overweight, Obesity | Phase 1 | Not yet recruiting | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | 42 | 2026-04-08 | 2026-03-30 |
| A Study of LY4515100 in Healthy Participants LY4515100 via SAD, LY4515100 via MAD, LY4515100 - Healthy | Phase 1 | Recruiting | Eli Lilly and Company | 209 | 2026-01-15 | 2026-11-05 |
| Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants Repotrectinib, Metformin, Digoxin - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 30 | 2025-12-31 | 2026-03-27 |
| A Study to Evaluate the Drug Interactions of HRS-7535 With Acetaminophen, Digoxin, Rosuvastatin, and Omeprazole in Obese or Overweight Subjects HRS-7535 Tablets, Paracetamol Tablets, Digoxin Tablets - Obesity, Overweight | Phase 1 | Completed | Shandong Suncadia Medicine Co., Ltd. | 40 | 2025-12-07 | 2026-06-29 |
| A Study in Healthy People to Test Whether BI 3000202 Affects How 2 Other Medicines (Rosuvastatin and Digoxin) Are Taken up in the Body BI 3000202, Rosuvastatin, Digoxin - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 14 | 2025-11-05 | 2025-12-22 |
| A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin KarXT, Midazolam, Fexofenadine - Healthy Volunteers | Phase 1 | Completed | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 62 | 2025-09-29 | 2026-07-22 |
| Efficacy Study of Digoxin Combined With Serplulimab and Chemotherapy in First-Line Treatment of MSS Advanced Colorectal Cancer Digoxin, Fuquinitinib, Tislelizumab - Colorectal Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Fudan University | 20 | 2025-08-01 | 2025-08-01 |
| A Study to Evaluate VH4524184 Tablet Absorption, Effects of Food, and Interactions With Other Drugs in Healthy Adults VH4524184, Itraconazole, Rifabutin - HIV Infections | Phase 1 | Completed | ViiV Healthcare | 126 | 2025-07-07 | 2026-03-09 |
| A Drug Drug Interaction Study to Evaluate the Effect of VCT220 on the Pharmacokinetics of Repaglinide, Rosuvastatin, and Digoxin in Healthy, Overweight, and Obese Subjects Drug: VCT220, Repaglinide, Rosuvastatin, and Digoxin - Obesity &Amp; Overweight | Phase 1 | Completed | Vincentage Pharma Co., Ltd | 24 | 2025-07-01 | 2026-03-31 |
| A Phase 1 Study of PROT-001. PROT-001, Rosuvastatin 10mg, Digoxin 0.25 mg - Healthy | Phase 1 | Completed | Protego Biopharma Pty Ltd | 102 | 2025-05-29 | 2026-01-30 |
| Drug-durg Interaction of RAY1225 With Warfarin, Atorvastatin, Metformin and Digoxin RAY1225, atorvastatin calcium tablet, Metformin Tablets - Obesity | Phase 1 | Active not recruiting | Guangdong Raynovent Biotech Co., Ltd | 32 | 2025-04-14 | 2026-01-23 |
| Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib Saruparib, Digoxin, Furosemide - Advanced Solid Malignancies | Phase 1 | Active not recruiting | AstraZeneca | 41 | 2025-03-25 | 2026-10-01 |
Showing 20 of 162. Sign in to see all of them.
Diabetes Mellitus, Type 2 (8) · Obesity (7) · Overweight (7) · Arthritis, Rheumatoid (4) · Diabetes Mellitus (4) · Neoplasms (4) · HIV Infections (3) · Melanoma (3) · Acquired Immunodeficiency Syndrome (2) · Carcinoma, Non-Small-Cell Lung (2) · Epilepsy (2) · Neoplasm Metastasis (2) · Tuberculosis (2) · Alzheimer Disease (1) · Angioedemas, Hereditary (1)
Boehringer Ingelheim (15) · Eli Lilly and Company (10) · AstraZeneca (8) · Bristol-Myers Squibb (8) · GlaxoSmithKline (4) · Novo Nordisk A/S (4) · Celgene (3) · Jiangsu HengRui Medicine Co., Ltd. (3) · Merck Sharp & Dohme LLC (3) · ViiV Healthcare (3) · Astellas Pharma Europe B.V. (2) · Astellas Pharma Global Development, Inc. (2) · Biogen (2) · DICE Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company (2) · Guangdong Raynovent Biotech Co., Ltd (2)
United States (74) · China (27) · Germany (18) · United Kingdom (9) · Canada (5) · France (5) · Australia (4) · Sweden (4) · Belgium (3) · Italy (3) · Japan (3) · Netherlands (3) · South Korea (3) · Spain (3) · Israel (2)
Arthur Frankel, MD (2) · Adeep Puri (1) · Alex Vo, PhD (1)
PMID 23497760, PMID 23754514, PMID 25117183, PMID 25345427, PMID 25387217, PMID 26426736, PMID 26514315, PMID 28349387, PMID 28357715, PMID 30427584, PMID 31385617, PMID 34477937, PMID 35118821, PMID 35931943, PMID 36700734, PMID 37768317, PMID 39368039, PMID 39777405, PMID 40291342, PMID 40587051, PMID 41058119, PMID 41845869, PMID 42624857
2008 (2), 2014 (2), 2015 (2), 2019 (2), 2004 (1), 2016 (1), 2017 (1), 2025 (1), R01HD106588 (1), U01AA026962 (1)