7 completed, 5 terminated, 3 recruiting, 2 not yet recruiting. 20 Phase 2, 5 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 7, Terminated 5, Recruiting 3, Not yet recruiting 2, Unknown 2, Withdrawn 1 |
| Phase 1 | 5 | Completed 1, Not yet recruiting 1, Recruiting 1, Terminated 1, Unknown 1 |
Follow Digoxin: new trials by email Literature Review of Digoxin trials Research Report on Digoxin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Digoxin Medulloblastoma Study Digoxin - Medulloblastoma, Medulloblastoma, Non-WNT/Non-SHH | Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 23 | 2026-01-15 | 2026-11-04 |
| Digoxin and Senolysis in Heart Failure and Diabetes Mellitus Digoxin 0.125 MG - Heart Failure, Systolic, Diabetes Mellitus, Type 2 | Phase 2 | Not yet recruiting | University of Leeds | 100 | 2025-09-01 | 2024-12-06 |
| Efficacy Study of Digoxin Combined With Serplulimab and Chemotherapy in First-Line Treatment of MSS Advanced Colorectal Cancer Digoxin, Fuquinitinib, Tislelizumab - Colorectal Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Fudan University | 20 | 2025-08-01 | 2025-08-01 |
| Digoxin In NASH (CODIN) Digoxin, Placebo - NASH, NAFLD | Phase 2 | Recruiting | Yale University | 144 | 2025-06-05 | 2026-05-26 |
| Trial of Oral Digoxin in Individuals With Amyotrophic Lateral Sclerosis (ALS) Digoxin - ALS (Amyotrophic Lateral Sclerosis) | Phase 2 | Completed | Massachusetts General Hospital | 41 | 2025-05-27 | 2026-07-30 |
| PK/PD of Digoxin in Infants With SVHD PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease - Single-ventricle, Infant Conditions | Phase 1 / Phase 2 | Completed | Duke University | 24 | 2024-10-10 | 2026-08-14 |
| Furosemide-Digoxin vs. Polidocanol for Cutaneous Warts Intralesional combined furosemide (10 mg/ml) and digoxin (0.25 mg/ml), Intralesional polidocanol 2% - Cutaneous Warts, Human Papilloma Virus (HPV) | Phase 2 | Completed | Benha University | 64 | 2024-09-01 | 2026-01-02 |
| Phase 2A Pilot C3 Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer Gemcitabine and C3 (Metformin, Simvastatin, and Digoxin), C3 (Metformin, Simvastatin, and Digoxin) only - Pancreatic Cancer Metastatic | Phase 1 / Phase 2 | Recruiting | State University of New York - Downstate Medical Center | 25 | 2024-04-17 | 2026-08-03 |
| Evaluating the Effect of Digoxin and Ursodeoxycholic Acid in Patients With Rheumatoid Arthritis Placebo, Digoxin 0.25 mg, Ursodeoxycholic acid (UDCA) 500 mg - Rheumatoid Arthritis | Phase 2 | Completed | Tanta University | 90 | 2021-11-01 | 2023-03-22 |
| Digoxin In Treatment of Alcohol Associated Hepatitis Intravenous digoxin - Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury | Phase 2 | Terminated | Yale University | 23 | 2021-10-08 | 2026-09-29 |
| FOLFIRINOX With Digoxin in Patients With Resectable Pancreatic Cancer Digoxin, 5Fluorouracil, Calcium Leucovorin - Pancreas Cancer, Adenocarcinoma of the Pancreas | Phase 2 | Terminated | University of Nebraska | 11 | 2021-02-12 | 2026-10-21 |
| Digoxin for Patients With Non-alcoholic Steatohepatitis (NASH) Digoxin tablet, Placebo - Nonalcoholic Steatohepatitis | Phase 2 | Withdrawn | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 2020-06-01 | 2023-02-22 | |
| Safety and Activity of Digoxin With Decitabine in Adult AML and MDS Decitabine, Digoxin - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 1 / Phase 2 | Terminated | Fox Chase Cancer Center | 1 | 2017-06-02 | 2021-03-16 |
| Potentiation of Cisplatin-based Chemotherapy by Digoxin in Advanced Unresectable Head and Neck Cancer Patients Digoxin - Head and Neck Cancer | Phase 1 / Phase 2 | Unknown | Assistance Publique - Hôpitaux de Paris | 15 | 2017-01-01 | 2017-10-19 |
| A Phase 2 Efficacy Study of CLS003 ICVT in Subjects With Cutaneous Warts. CLS003, Furosemide, Digoxin - Cutaneous Warts | Phase 2 | Completed | Maruho Co., Ltd. | 81 | 2015-01-01 | 2016-07-28 |
| Phase II Multicentric Study of Digoxin Per os in Classic or Endemic Kaposi' s Sarcoma digoxin - Kaposi' s Sarcoma, Classic Kaposi' s Sarcoma | Phase 2 | Unknown | Assistance Publique - Hôpitaux de Paris | 17 | 2014-09-01 | 2018-07-23 |
| Capecitabine With Digoxin for Metastatic Breast Cancer Capecitabine, Digoxin - Metastatic Breast Cancer | Phase 2 | Terminated | Western Regional Medical Center | 16 | 2013-04-01 | 2018-02-22 |
| DIG-HIF-1 Pharmacodynamic Trial in Newly Diagnosed Operable Breast Cancer Digoxin - Breast Cancer | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 6 | 2013-01-01 | 2020-01-31 |
| Digoxin for Recurrent Prostate Cancer Digoxin - Prostate Cancer | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 16 | 2010-09-01 | 2025-05-04 |
| Second Line Erlotinib (Tarceva) Plus Digoxin in Non-Small Cell Lung Cancer Erlotinib plus Digoxin - Carcinoma, Non-Small Cell Lung | Phase 2 | Terminated | University of Louisville | 26 | 2006-02-01 | 2018-03-29 |
Breast Neoplasms (2) · Non-alcoholic Fatty Liver Disease (2) · Pancreatic Neoplasms (2) · Alcohol-Induced Disorders (1) · Amyotrophic Lateral Sclerosis (1) · Arthritis, Rheumatoid (1) · Autoimmune Diseases (1) · Carcinoma, Non-Small-Cell Lung (1) · Chemical and Drug Induced Liver Injury (1) · Colorectal Neoplasms (1) · Diabetes Mellitus, Type 2 (1) · Fatty Liver, Alcoholic (1) · Head and Neck Neoplasms (1) · Heart Failure, Systolic (1) · Hepatitis (1)
Assistance Publique - Hôpitaux de Paris (2) · Yale University (2) · Benha University (1) · Duke University (1) · Fox Chase Cancer Center (1) · Fudan University (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Maruho Co., Ltd. (1) · Massachusetts General Hospital (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · State University of New York - Downstate Medical Center (1) · Tanta University (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1) · University of Leeds (1)
United States (11) · China (2) · Egypt (2) · France (2) · Netherlands (1) · United Kingdom (1)
Bubu A Banini, MD, PhD (1) · Bubu Banini, MD, PhD (1) · Christoph Hornik, MD (1) · Dalia Salah Seif, PHD (1) · Enass Yousef Osman, PHD (1) · Ghada Shams, MD (1) · Goetz H Kloecker, MD, MSPH (1) · Jean Grem, MD (1) · Jianqing Lin, MD (1) · Jiaxin Niu, MD, PhD (1) · Jonathan Metts, MD (1) · Laura Metrock, MD (1) · Mariam George Tadros Bolous, Master (1) · Medhat Ismail Abdel Hamid, Professor (1)
PMID 29414684, PMID 30580460, PMID 39498340
2014 (1), 2015 (1), P50CA127297 (1), R01DK134624 (1), R01HD106588 (1)