12 completed, 2 unknown, 1 withdrawn. 8 Not applicable, 1 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 6, Unknown 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow CRT-D: new trials by email Literature Review of CRT-D trials Research Report on CRT-D
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CRT-P or CRT-D in Dilated Cardiomyopathy CRT-D, CRT-P - Cardiomyopathy, Dilated, 3B | Not applicable | Unknown | University Hospital Olomouc | 924 | 2020-06-01 | 2020-03-25 |
| Strategic Management to Improve CRT Using Multi-Site Pacing Post Approval Study (Reference # C1918) CRT-D - Left Ventricular Dysfunction | Not applicable | Completed | Boston Scientific Corporation | 586 | 2018-01-05 | 2022-01-03 |
| Strategic Management to Optimize Response To Cardiac Resynchronization Therapy CRT-D - Heart Failure | Not applicable | Completed | Boston Scientific Corporation | 699 | 2017-08-01 | 2022-04-05 |
| Heart Failure and Sudden Cardiac Death Japan Registry CRT-D, ICD, PM / CRT-P - Heart Failure, Arrhythmias, Cardiac | Completed | Boston Scientific Corporation | 354 | 2017-07-21 | 2022-02-14 | |
| Cardiac Resynchronization in the Elderly Cardiac Resynchronization Therapy Pacemaker, Cardiac Resynchronization Therapy Defibrillator - Heart Failure | Not applicable | Completed | Samir Saba | 102 | 2017-03-21 | 2023-12-07 |
| Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF MitraClip, Optimal Medical Therapy, CRT-D - Functional Mitral Regurgitation, Heart Failure | Not applicable | Withdrawn | Montreal Heart Institute | 2016-12-01 | 2020-02-27 | |
| Clinical Study to Confirm MRI Safety and Effectiveness Using St. Jude Medical (SJM) Cardiac Rhythm Management Systems SJM Implantable cardiac devices - Bradycardia, Tachycardia | Completed | Abbott Medical Devices | 119 | 2016-11-10 | 2019-08-05 | |
| Junctional AV Ablation in CRT-D: JAVA-CRT Atrioventricular junctional (AVJ) ablation, Cardiac resynchronization therapy - defibrillator - Systolic Heart Failure, Atrial Fibrillation (Permanent) | Not applicable | Completed | University of Rochester | 26 | 2016-10-01 | 2022-01-25 |
| Budapest Upgrade CRT Study (Version 009-4.1) CRT-D - Cardiomyopathy | Not applicable | Completed | Semmelweis University Heart and Vascular Center | 360 | 2014-11-01 | 2023-06-06 |
| Evaluation of Automatic Threshold Algorithms CRT-D - Heart Failure | Not applicable | Completed | Boston Scientific Corporation | 216 | 2014-04-01 | 2018-04-19 |
| Italian Registry On Multipoint Left Ventricular Pacing CRT-D - Heart Failure, Ventricular Fibrillation | Unknown | University of Rome Tor Vergata | 436 | 2013-08-01 | 2017-09-26 | |
| Evaluation of Left Ventricular Autothreshold, Phase Two CRT-D - Heart Failure | Completed | Boston Scientific Corporation | 100 | 2010-11-01 | 2012-10-03 | |
| Cardiac Resynchronization Therapy (CRT) Based Heart Failure Monitoring Study Cardiac Resynchronization Therapy, HeartPOD™ System - Heart Failure | Completed | Abbott Medical Devices | 8 | 2008-01-01 | 2020-10-12 | |
| Safety and Efficacy Study of RENEWAL 4 AVT CRT-D - Heart Failure, Tachycardia | Phase 2 / Phase 3 | Completed | Boston Scientific Corporation | 170 | 2004-07-01 | 2007-06-25 |
| Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) Patients ICD, CRT-D - Sleep Apnoea | Phase 4 | Completed | LivaNova | 755 | 2004-04-01 | 2008-07-02 |
Heart Failure (10) · Atrial Fibrillation (2) · Tachycardia (2) · Ventricular Fibrillation (2) · Arrhythmias, Cardiac (1) · Atrial Flutter (1) · Bradycardia (1) · Cardiomyopathies (1) · Death, Sudden, Cardiac (1) · Heart Failure, Systolic (1) · Mitral Valve Insufficiency (1) · Muscular Dystrophy, Duchenne (1) · Sleep Apnea Syndromes (1) · Tachycardia, Ventricular (1) · Ventricular Dysfunction, Left (1)
Boston Scientific Corporation (6) · Abbott Medical Devices (2) · LivaNova (1) · Montreal Heart Institute (1) · Samir Saba (1) · Semmelweis University Heart and Vascular Center (1) · University Hospital Olomouc (1) · University of Rochester (1) · University of Rome Tor Vergata (1)
United States (7) · Germany (4) · Italy (3) · France (2) · Japan (2) · Australia (1) · Canada (1) · Czechia (1) · Greece (1) · Hungary (1) · India (1) · Ireland (1) · Israel (1) · Netherlands (1) · New Zealand (1)
Anita Asgar, MD (1) · Annamaria Kosztin, MD (1) · Giovanni Forleo (1) · Grant Kim (1) · Ilan Goldenberg, Prof. MD (1) · Johannes Sperzel, MD (1) · Jonathan S Steinberg, MD (1) · Kazutaka Aonuma, Professor (1) · Kenneth Ellenbogen, MD (1) · Kenneth L Ellenbogen, M.D. (1) · Michael R. Gold, MD (1) · Milos Taborsky, MD, PhD (1) · Richard Troughton, MD (1)
PMID 24502608, PMID 27189954, PMID 28339581, PMID 33724264, PMID 35043250, PMID 35357219, PMID 35791276, PMID 36350362, PMID 37183700, PMID 39614838, PMID 40296252