7 completed, 4 unknown, 1 recruiting, 1 suspended. 6 Not applicable, 3 Phase 1, 3 Phase 2, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Unknown 3, Completed 2, Recruiting 1 |
| Phase 1 | 3 | Completed 2, Suspended 1 |
| Phase 2 | 3 | Completed 1, Suspended 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Phase 4 | 1 | Terminated 1 |
Follow core decompression: new trials by email Literature Review of core decompression trials Research Report on core decompression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH) Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), core decompression - Osteonecrosis of Femoral Head | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 30 | 2026-12-31 | 2026-04-23 |
| Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis Core Decompression, Core Decompression Procedure with Autologous Bone Marrow Aspirate Concentrate - Osteonecrosis of the Femoral Head, Avascular Necrosis of the Femoral Head | Not applicable | Recruiting | Johns Hopkins University | 192 | 2025-04-01 | 2026-09-17 |
| Triple-Modal Therapy in Early-Stage Femoral Head Osteonecrosis (TM-ONFH) Core decompression, stromal vascular fraction (SVF), Hyperbaric Oxygen Therapy (HBOT) - Osteonecrosis of the Femoral Head | Completed | Ankara City Hospital Bilkent | 24 | 2025-01-22 | 2026-05-06 | |
| Hyperbaric Oxygen Therapy Versus Core Decompression Augmented With Bone Substitute in Pre Collapse of Avascular Necrosis of Femoral Head core decompression - AVN | Completed | Hamad Medical Corporation | 19 | 2017-09-13 | 2020-12-10 | |
| Study for the Treatment of the Bone Marrow Edema:Core Decompression VS Bone Marrow Concentrate (BMC) VS Bone Substitute autologous bone marrow concentrate, bone substitute i-FactorTM, core decompression - Bone Marrow Edema | Phase 4 | Terminated | Istituto Ortopedico Rizzoli | 1 | 2016-03-11 | 2018-08-09 |
| Porous Tantalum Rods Improve the Hip Joint Function of Patients With Avascular Necrosis of the Femoral Head porous tantalum rod, core decompression - Femoral Neck Fracture | Not applicable | Unknown | Qinghai University | 100 | 2015-05-01 | 2016-08-24 |
| A Novel Reconstruction Device for Osteonecrotic Femoral Head Efficacy Evaluation Core Decompression, Osteonecrotic Repair Device - Osteonecrosis | Not applicable | Completed | National Taiwan University Hospital | 20 | 2014-06-01 | 2019-09-26 |
| Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression core decompression - Avascular Necrosis of Bone | Not applicable | Unknown | BG Trauma Center Ludwigshafen | 20 | 2014-02-01 | 2014-11-13 |
| Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression core decompression - Avascular Necrosis of Bone | Not applicable | Unknown | BG Trauma Center Ludwigshafen | 20 | 2014-02-01 | 2014-11-18 |
| Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head core decompression - Osteonecrosis | Phase 3 | Completed | Istituto Ortopedico Rizzoli | 104 | 2013-04-01 | 2023-05-12 |
| Implantation of Bone Marrow Cells to Treat Avascular Necrosis of Femoral Head (ANFH) core decompression, Enriched BMCs implantation combined with core decompression - Avascular Necrosis of Femur Head | Phase 2 / Phase 3 | Unknown | Guangdong Provincial People's Hospital | 60 | 2009-03-01 | 2012-08-14 |
| Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease Core decompression - Bone Avascular Necrosis, Sickle Cell Anemia | Not applicable | Completed | UCSF Benioff Children's Hospital Oakland | 50 | 1999-06-01 | 2017-02-15 |
| Treatment of Osteonecrosis of the Femoral Head by Bone Marrow Transplantation core decompression, Bone marrow implantation into the necrotic lesion - Necrosis | Phase 1 | Completed | Erasme University Hospital | 21 | 1999-01-01 | 2020-02-28 |
| Core Decompression With or Without Cement Packing for ONFH Core Decompression, PMMA augmentation - Osteonecrosis | Phase 1 / Phase 2 | Completed | University of Minnesota | 37 | 1997-01-01 | 2020-01-18 |
Osteonecrosis (8) · Femur Head Necrosis (3) · Legg-Calve-Perthes Disease (2) · Necrosis (2) · Anemia, Sickle Cell (1) · Arthritis (1) · Bone Diseases (1) · Connective Tissue Diseases (1) · Disease Progression (1) · Femoral Neck Fractures (1) · Genetic Diseases, Inborn (1) · Hematologic Diseases (1) · Musculoskeletal Diseases (1) · Osteochondritis Dissecans (1) · Pain (1)
BG Trauma Center Ludwigshafen (2) · Istituto Ortopedico Rizzoli (2) · Ankara City Hospital Bilkent (1) · Erasme University Hospital (1) · Guangdong Provincial People's Hospital (1) · Hamad Medical Corporation (1) · Johns Hopkins University (1) · National Taiwan University Hospital (1) · Qinghai University (1) · Sclnow Biotechnology Co., Ltd. (1) · UCSF Benioff Children's Hospital Oakland (1) · University of Minnesota (1)
China (2) · Germany (2) · Italy (2) · United States (2) · Belgium (1) · Qatar (1) · Turkey (Türkiye) (1)
Dante Dallari, Surgeon (1) · Elliott P. Vichinsky (1) · Heling Zhang, Master (1) · Lei Guo, Dr. (1) · Lynne C Jones, PhD (1) · Michael A Mont, MD (1) · Stuart B Goodman, MD, PhD (1) · Thomas Kremer, Phd, MD (1) · Ulrich Kneser, Phd, MD (1)
PMID 25315149, PMID 2643938, PMID 32678055, PMID 7934797
U01AR080993 (1)