19 completed, 3 recruiting, 3 terminated, 3 unknown. 20 Not applicable, 3 Phase 1, 1 Early Phase 1, 1 Phase 2, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Transcutaneous Vagus Nerve Stimulation on Pain and Brain Activity in Healthy Adults Active transcutaneous vagus nerve stimulation, Sham transcutaneous vagus nerve stimulation, Cold pressor test - Acute Pain, Pain Perception | Not applicable | Not yet recruiting | David A. Purger | 20 | 2026-09-01 | 2026-09-18 |
| Neurophysiological and Autonomic Responses to Acute Physical and Emotional Stress: An EEG Study Cold Pressor Test, Negative Autobiographical Memory Recall, Affective Picture-Viewing Task - Stress, Acute Stress | Not applicable | Recruiting | University of Pavia | 30 | 2026-08-01 | 2026-08-24 |
| Gamifying Hand Therapy: Development of a Mixed Reality Rhythm Game to Reduce Pain and Improve Motivation Cold pressor test, Exercise under resistance - Analgesia Through Mixed Reality | Not applicable | Completed | Western University | 20 | 2026-06-08 | 2026-07-29 |
| Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia - Down Syndrome, Autonomic Dysfunction | Phase 3 | Recruiting | University of Colorado, Denver | 200 | 2026-04-06 | 2026-10-13 |
| Kidney Blood Flow During Exercise in Older African American Adults Acute exercise, Cold pressor test, Mental stress test - Healthy | Not applicable | Active not recruiting | University of Massachusetts, Boston | 12 | 2024-12-04 | 2026-07-15 |
| Detection of Electrodermal Activity in Pain 1 Stroop task, Cold pressor test - Healthy, Acute Pain | Not applicable | Active not recruiting | Copenhagen University Hospital, Hvidovre | 37 | 2024-11-10 | 2026-03-19 |
| Neural Control of Kidney Blood Flow During Exercise in African American Adults Acute exercise, Cold pressor test, Mental stress test - Healthy | Not applicable | Completed | University of Massachusetts, Boston | 33 | 2024-09-30 | 2026-08-25 |
| Novel Multimodal Neural, Physiological, and Behavioral Sensing and Machine Learning for Mental States Virtual human social interaction, Cold pressor test - No Condition, Study Mental State in Healthy Populations and Drug-resistant Epilepsy Patients With Existing iEEG | Not applicable | Recruiting | University of Southern California | 90 | 2024-08-01 | 2025-10-01 |
| The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function. TruBeet inorganic beetroot juice, Caffeine, Cold pressor test - Nitrate, Caffeine | Not applicable | Completed | Loughborough University | 24 | 2023-12-05 | 2025-09-12 |
| Sex Differences in Sympathetic Vascular Reactivity at High Altitude Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 17 | 2022-07-28 | 2024-09-19 |
| Recognizing Pain Intensity in Alzheimer's Disease cognitive assessment, Cold Pressor Test, digital sensor of Nociception Level Index - Alzheimer Disease, Pain | Not applicable | Terminated | Centre Hospitalier Universitaire de Saint Etienne | 28 | 2021-11-24 | 2024-10-15 |
| Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity Cold Pressor Test - Obesity, Healthy | Early Phase 1 | Completed | University of Missouri-Columbia | 73 | 2020-12-09 | 2026-07-28 |
| Influence of COVID-19 on Vascular Endothelial Function Carotid Artery Reactivity Testing - COVID, Vascular; Damage | Unknown | Radboud University Medical Center | 203 | 2020-07-14 | 2022-01-19 | |
| Catastrophizing and Virtual Reality's Impact on Pain in Patients With Fibromyalgia Cold Pressor Test, Cold Pressor Test + Virtual Reality - Fibromyalgia, Pain | Not applicable | Completed | Aalborg University | 44 | 2020-02-01 | 2022-03-21 |
| Non-Invasive Bioelectronic Analytics Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test - Autonomic Dysfunction, Autonomic Imbalance | Enrolling by invitation | Northwell Health | 48 | 2019-08-29 | 2026-06-09 | |
| Sensitivity, Threshold, Tolerance and Pain Recognition in Schizophrenia Patients and Their Relatives. Cold Pressor test - Pain Recognition, Schizophrenia | Not applicable | Unknown | HaEmek Medical Center, Israel | 200 | 2019-08-29 | 2022-04-26 |
| Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia. Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 14 | 2019-08-04 | 2022-10-31 |
| Brain BOLD fMRI in Hypertensive and Normotensive Participants Cold Pressor test, PinPrick test - Hypertension,Essential | Completed | Centre Hospitalier Universitaire Vaudois | 84 | 2018-08-16 | 2023-02-21 | |
| Evaluating VR Therapy Using Cold Pressor Test Virtual Reality, Cold Pressor - Pain | Not applicable | Completed | Janet Vittone | 48 | 2017-09-10 | 2019-06-11 |
| The Association Between Conditioned Pain Modulation and Pain Catastrophizing in Chronic Low Back Pain PPT measurement, Pain catastrophizing scale, Cold Pressor Test - Catastrophizing Pain, Pain, Somatic | Not applicable | Completed | Aalborg University | 44 | 2017-05-01 | 2018-12-24 |
Showing 20 of 32. Sign in to see all of them.
Pain (4) · Aneurysm (3) · Motor Activity (3) · Stress, Psychological (3) · Acute Pain (2) · Hypertension (2) · Inflammation (2) · Obesity (2) · Opioid-Related Disorders (2) · Primary Dysautonomias (2) · Alzheimer Disease (1) · Autonomic Nervous System Diseases (1) · Binge-Eating Disorder (1) · Cardiomyopathies (1) · Cardiovascular Diseases (1)
Aalborg University (2) · University of Alberta (2) · University of Massachusetts, Boston (2) · University of Missouri-Columbia (2) · University of Turku (2) · Beth Israel Deaconess Medical Center (1) · Centre Hospitalier Universitaire Vaudois (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Copenhagen University Hospital, Hvidovre (1) · David A. Purger (1) · Georgetown University (1) · HaEmek Medical Center, Israel (1) · Janet Vittone (1) · Lithuanian University of Health Sciences (1) · Loughborough University (1)
United States (14) · Canada (4) · Denmark (4) · Finland (2) · France (1) · Israel (1) · Italy (1) · Netherlands (1) · Switzerland (1) · United Kingdom (1)
Rachel C Drew, PhD (2) · Sean van Diepen, MD, MSc (2) · Allan Geliebter, PhD (1) · Anand Chockalingam, MD (1) · Andre S van Petersen, PhD (1) · Craig D Steinback, PhD (1) · Craig Steinback, PhD (1) · David A Purger, MD, PhD (1) · Dorte Drachman, Msc. (1) · Einat Mader, MD (1) · Gregoire Wuerzner, MD (1) · Haack Monika, PhD (1) · Janet Vittone (1)
PMID 25901477, PMID 25963754, PMID 26741741, PMID 28344100, PMID 30025944, PMID 34446089, PMID 36454199, PMID 42402630
2018 (1), R15HL152359 (1), R61MH135407 (1), T32AG000279 (1), U01HL072515 (1)