6 completed, 3 recruiting, 2 active not recruiting, 1 suspended. 14 Phase 1, 7 Phase 2.
Follow CliniMACS: new trials by email Literature Review of CliniMACS trials Research Report on CliniMACS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Thymoglobulin, Cyclophosphamide, Fludarabine - Hematologic Malignancy | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 30 | 2025-09-25 | 2026-06-02 |
| Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML Rabbit Anti thymocyte globulin, Busulfan, Fludarabine - AML, Childhood, Aml | Phase 1 / Phase 2 | Recruiting | Washington University School of Medicine | 68 | 2024-11-15 | 2026-08-24 |
| Study of CD19 Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia CD19-CAR(Mem) T-cells, Cyclophosphamide, Fludarabine - Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia, Refractory | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 60 | 2024-02-14 | 2026-08-31 |
| Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID) Anti-thymocyte globulin (rabbit), Busulfan, Fludarabine - Severe Combined Immunodeficiency | Phase 1 / Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 4 | 2021-09-02 | 2026-09-16 |
| Evaluation of CD19-Specific CAR Engineered Autologous T-Cells for Treatment of Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia Cyclophosphamide, Fludarabine, Mesna - Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia, Refractory | Phase 1 / Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 24 | 2018-07-24 | 2026-08-11 |
| Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents Fludarabine, Cyclophosphamide, anti-thymocyte globulin - Haploidentical Hematopoietic Stem Cell Transplantation, Malignant Disease | Phase 1 / Phase 2 | Unknown | Asan Medical Center | 30 | 2017-01-01 | 2017-03-28 |
| Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants CL20-i4-EF1α-hγc-OPT, Busulfan, CliniMacs - Severe Combined Immunodeficiency Disease, X-linked | Phase 1 / Phase 2 | Suspended | St. Jude Children's Research Hospital | 28 | 2016-08-17 | 2025-11-10 |
| A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or Lymphomas CD133+ selected autologous stem cell infusion, IL-2, hu14.18K322A - Neuroblastoma, Lymphoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 8 | 2014-10-10 | 2017-12-22 |
| A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas alemtuzumab, fludarabine, sirolimus - Ewing Sarcoma, Gastrointestinal Tumor | Phase 1 | Completed | St. Jude Children's Research Hospital | 23 | 2012-08-20 | 2026-02-06 |
| Combination Chemotherapy, Monoclonal Antibody, and Natural Killer Cells in Treating Young Patients With Recurrent or Refractory Neuroblastoma Humanized anti-GD2 antibody, Chemotherapy, Cytokines - Neuroblastoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 34 | 2012-04-01 | 2018-11-15 |
| Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps Fludarabine, Thiotepa, Total Body Irradiation (TBI) - Hematologic Malignancies, Acute Leukemia | Phase 1 / Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 8 | 2011-04-01 | 2025-05-31 |
| Pilot Study of Expanded, Donor Natural Killer Cell Infusions for Refractory Non-B Lineage Hematologic Malignancies and Solid Tumors Haploidentical donor derived natural killer cell infusion, Chemotherapy, CliniMACS - Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute, T-Cell | Phase 1 | Completed | St. Jude Children's Research Hospital | 22 | 2008-09-01 | 2014-04-24 |
| Reduced Intensity Haploidentical Transplant for Hematological Malignancies Haploidentical Allogeneic Transplantation - Hematological Malignancies | Phase 1 / Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 34 | 2006-09-01 | 2025-04-30 |
| Haploidentical Stem Cell Transplant for Patients With Sickle Cell Disease and Prior Stroke or Abnormal Transcranial Ultrasound Hematopoietic Stem Cell Transplantation, CliniMACS, See intervention description - Sickle Cell Disease | Phase 1 | Completed | St. Jude Children's Research Hospital | 5 | 2005-04-01 | 2017-04-26 |
Hematologic Neoplasms (4) · Neuroblastoma (3) · Leukemia (2) · Leukemia, Myeloid, Acute (2) · Lymphoma (2) · Myelodysplastic Syndromes (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Adenocarcinoma, Clear Cell (1) · Anemia, Sickle Cell (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Renal Cell (1) · Digestive System Neoplasms (1) · Graft vs Host Disease (1) · Hodgkin Disease (1) · Immunologic Deficiency Syndromes (1)
St. Jude Children's Research Hospital (10) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2) · Asan Medical Center (1) · Washington University School of Medicine (1)
United States (13) · South Korea (1)
Aimee C. Talleur, MD (2) · Neal Flomenberg, MD (2) · Stephen Gottschalk, MD (2) · Brando Triplett, MD (1) · Brandon M. Triplett, MD (1) · Brandon Triplett, MD (1) · David Shook, MD (1) · Dolores Grosso, DNP, CRNP (1) · Ewelina Mamcarz, MD (1) · Ho Joon Im, MD, PhD (1) · Thomas M Pfeiffer, M.D. (1) · Wayne L. Furman, MD (1) · Wing Leung, M.D. (1)
PMID 23416852, PMID 30995372, PMID 35446934
P01HL053749 (1), R01CA113482 (1)