10 completed, 6 active not recruiting, 3 recruiting, 3 terminated. 25 Phase 2, 7 Phase 1.
Follow CliniMACS: new trials by email Literature Review of CliniMACS trials Research Report on CliniMACS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML Rabbit Anti thymocyte globulin, Busulfan, Fludarabine - AML, Childhood, Aml | Phase 1 / Phase 2 | Recruiting | Washington University School of Medicine | 68 | 2024-11-15 | 2026-08-24 |
| Haplo-identical Viral-Specific T-cells for Treatment of Cytomegalovirus and Adenovirus Infections After Hematopoietic Cell Transplantation VST infusion, CliniMACS - Cytomegalovirus, Adenovirus | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 42 | 2023-08-01 | 2026-02-23 |
| CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic Malignancies CliniMACS, Bone Marrow Transplant, Hyperfractionated Total Body Irradiation - Hematologic Diseases, Hematologic Malignancy | Phase 2 | Withdrawn | Baptist Health South Florida | 2022-09-01 | 2022-09-27 | |
| Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID) Anti-thymocyte globulin (rabbit), Busulfan, Fludarabine - Severe Combined Immunodeficiency | Phase 1 / Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 4 | 2021-09-02 | 2026-09-16 |
| Haploidentical HCT for Severe Aplastic Anemia Anti-Thymocyte Globulin (Rabbit), Fludarabine, Cyclophosphamide - Aplastic Anemia, Bone Marrow Failure Syndrome | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 21 | 2021-01-21 | 2026-09-16 |
| TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies Cyclophosphamide, Fludarabine, Thiotepa - Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 69 | 2019-01-31 | 2026-09-15 |
| Conditioning SCID Infants Diagnosed Early Busulfan, Cell processing for TCRαβ+/CD19+ depletion - SCID | Phase 2 | Active not recruiting | Center for International Blood and Marrow Transplant Research | 56 | 2018-10-22 | 2026-10-26 |
| Evaluation of CD19-Specific CAR Engineered Autologous T-Cells for Treatment of Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia Cyclophosphamide, Fludarabine, Mesna - Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia, Refractory | Phase 1 / Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 24 | 2018-07-24 | 2026-08-11 |
| Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents Fludarabine, Cyclophosphamide, anti-thymocyte globulin - Haploidentical Hematopoietic Stem Cell Transplantation, Malignant Disease | Phase 1 / Phase 2 | Unknown | Asan Medical Center | 30 | 2017-01-01 | 2017-03-28 |
| Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants CL20-i4-EF1α-hγc-OPT, Busulfan, CliniMacs - Severe Combined Immunodeficiency Disease, X-linked | Phase 1 / Phase 2 | Suspended | St. Jude Children's Research Hospital | 28 | 2016-08-17 | 2025-11-10 |
| Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation Anti-thymocyte globulin (rabbit), Blinatumomab, Cyclophosphamide - Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 170 | 2016-07-14 | 2025-08-12 |
| Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies With Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device CliniMACs - Hematologic Malignancies | Phase 2 | Active not recruiting | Julie-An M. Talano | 60 | 2015-10-01 | 2026-05-01 |
| Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen Cyclophosphamide, Thiotepa, Fludarabine - Hematological Malignancies | Phase 2 | Terminated | St. Jude Children's Research Hospital | 24 | 2014-07-11 | 2018-02-07 |
| Therapy for Children With Advanced Stage Neuroblastoma cyclophosphamide, topotecan, hu14.18K322A - Neuroblastoma | Phase 2 | Completed | St. Jude Children's Research Hospital | 153 | 2013-07-05 | 2026-09-22 |
| Haploidentical Donor Hematopoietic Progenitor Cell and NK Cell Transplantation for Hematologic Malignancy Total Lymphoid Irradiation, Fludarabine, Cyclophosphamide - Leukemia, Lymphoma | Phase 2 | Completed | St. Jude Children's Research Hospital | 82 | 2013-05-16 | 2022-10-31 |
| Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma dexamethasone, vincristine sulfate, rituximab - Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood B-Lymphoblastic Lymphoma | Phase 2 | Completed | St. Jude Children's Research Hospital | 80 | 2013-04-15 | 2022-09-28 |
| Bulk Versus Fractionated Stem Cell Infusions in Patients With Hematologic Malignancies Undergoing Stem Cell Transplantation allogeneic hematopoietic stem cell transplantation, CliniMACS - Leukemia | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 116 | 2012-05-05 | 2022-12-29 |
| A Two-Step Approach to Bone Marrow Transplant Using Cells From Two Partially-Matched Relatives Total Body Irradiation (TBI), Donor Lymphocyte Infusion (DLI), Cyclophosphamide (CY) - Hematologic Malignancy, Leukemia | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 4 | 2012-03-01 | 2025-05-04 |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps Fludarabine, Thiotepa, Total Body Irradiation (TBI) - Hematologic Malignancies, Acute Leukemia | Phase 1 / Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 8 | 2011-04-01 | 2025-05-31 |
Showing 20 of 25. Sign in to see all of them.
Hodgkin Disease (8) · Leukemia (8) · Leukemia, Myeloid, Acute (8) · Hematologic Neoplasms (7) · Lymphoma, Non-Hodgkin (7) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (7) · Lymphoma (6) · Myelodysplastic Syndromes (6) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (4) · Leukemia, Myelomonocytic, Juvenile (4) · Anemia, Aplastic (3) · Multiple Myeloma (3) · Neoplasms, Plasma Cell (3) · Graft vs Host Disease (2)
St. Jude Children's Research Hospital (12) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (6) · Asan Medical Center (1) · Baptist Health South Florida (1) · Center for International Blood and Marrow Transplant Research (1) · Children's Hospital of Philadelphia (1) · Julie-An M. Talano (1) · Memorial Sloan Kettering Cancer Center (1) · Washington University School of Medicine (1)
United States (24) · Canada (1) · South Korea (1)
Neal Flomenberg, MD (5) · Brandon Triplett, MD (4) · Dolores Grosso, DNP, CRNP (3) · Aimee C. Talleur, MD (1) · Akshay Sharma, MBBS (1) · Amr Qudeimat, MD (1) · Brandon M. Triplett, MD (1) · Ewelina Mamcarz, MD (1) · Guenther Koehne, MD (1) · Ho Joon Im, MD, PhD (1) · Julie-An Talano, MD (1) · Michael Pulsipher, MD (1) · Naik Swati, MD (1) · Nancy J Bunin, MD (1) · Sara M. Federico, MD (1)
PMID 30995372, PMID 31765697, PMID 32221013, PMID 34871104, PMID 35446934, PMID 38937803
P01HL053749 (1)