17 completed, 8 active not recruiting, 6 recruiting, 3 terminated. 25 Phase 2, 14 Phase 1, 3 Not applicable, 1 Early Phase 1, 1 Phase 3.
Follow CliniMACS: new trials by email Literature Review of CliniMACS trials Research Report on CliniMACS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Thymoglobulin, Cyclophosphamide, Fludarabine - Hematologic Malignancy | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 30 | 2025-09-25 | 2026-06-02 |
| Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML Rabbit Anti thymocyte globulin, Busulfan, Fludarabine - AML, Childhood, Aml | Phase 1 / Phase 2 | Recruiting | Washington University School of Medicine | 68 | 2024-11-15 | 2026-08-24 |
| Study of CD19 Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia CD19-CAR(Mem) T-cells, Cyclophosphamide, Fludarabine - Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia, Refractory | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 60 | 2024-02-14 | 2026-08-31 |
| Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion CliniMACS - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission | Not applicable | Active not recruiting | Baylor College of Medicine | 3 | 2023-12-06 | 2026-10-08 |
| Haplo-identical Viral-Specific T-cells for Treatment of Cytomegalovirus and Adenovirus Infections After Hematopoietic Cell Transplantation VST infusion, CliniMACS - Cytomegalovirus, Adenovirus | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 42 | 2023-08-01 | 2026-02-23 |
| CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic Malignancies CliniMACS, Bone Marrow Transplant, Hyperfractionated Total Body Irradiation - Hematologic Diseases, Hematologic Malignancy | Phase 2 | Withdrawn | Baptist Health South Florida | 2022-09-01 | 2022-09-27 | |
| Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID) Anti-thymocyte globulin (rabbit), Busulfan, Fludarabine - Severe Combined Immunodeficiency | Phase 1 / Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 4 | 2021-09-02 | 2026-09-16 |
| Haploidentical HCT for Severe Aplastic Anemia Anti-Thymocyte Globulin (Rabbit), Fludarabine, Cyclophosphamide - Aplastic Anemia, Bone Marrow Failure Syndrome | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 21 | 2021-01-21 | 2026-09-16 |
| Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies CliniMACS - Sickle Cell Disease, Thalassemia Major | Not applicable | Completed | Timothy Olson | 8 | 2020-05-14 | 2026-04-28 |
| TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies Cyclophosphamide, Fludarabine, Thiotepa - Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 69 | 2019-01-31 | 2026-09-15 |
| Conditioning SCID Infants Diagnosed Early Busulfan, Cell processing for TCRαβ+/CD19+ depletion - SCID | Phase 2 | Active not recruiting | Center for International Blood and Marrow Transplant Research | 56 | 2018-10-22 | 2026-10-26 |
| Evaluation of CD19-Specific CAR Engineered Autologous T-Cells for Treatment of Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia Cyclophosphamide, Fludarabine, Mesna - Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia, Refractory | Phase 1 / Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 24 | 2018-07-24 | 2026-08-11 |
| Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF CliniMACs - Acquired Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria | Not applicable | Active not recruiting | Children's Hospital of Philadelphia | 50 | 2017-02-01 | 2026-06-17 |
| Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents Fludarabine, Cyclophosphamide, anti-thymocyte globulin - Haploidentical Hematopoietic Stem Cell Transplantation, Malignant Disease | Phase 1 / Phase 2 | Unknown | Asan Medical Center | 30 | 2017-01-01 | 2017-03-28 |
| Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants CL20-i4-EF1α-hγc-OPT, Busulfan, CliniMacs - Severe Combined Immunodeficiency Disease, X-linked | Phase 1 / Phase 2 | Suspended | St. Jude Children's Research Hospital | 28 | 2016-08-17 | 2025-11-10 |
| Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation Anti-thymocyte globulin (rabbit), Blinatumomab, Cyclophosphamide - Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 170 | 2016-07-14 | 2025-08-12 |
| Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies With Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device CliniMACs - Hematologic Malignancies | Phase 2 | Active not recruiting | Julie-An M. Talano | 60 | 2015-10-01 | 2026-05-01 |
| A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or Lymphomas CD133+ selected autologous stem cell infusion, IL-2, hu14.18K322A - Neuroblastoma, Lymphoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 8 | 2014-10-10 | 2017-12-22 |
| Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen Cyclophosphamide, Thiotepa, Fludarabine - Hematological Malignancies | Phase 2 | Terminated | St. Jude Children's Research Hospital | 24 | 2014-07-11 | 2018-02-07 |
| Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC Transplant of stem cells with CD3+/CD19+ depletion (CliniMACs) - Leukemia, Inborn Errors of Metabolism | Early Phase 1 | Recruiting | Children's Hospital of Philadelphia | 100 | 2013-12-01 | 2026-02-20 |
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Leukemia, Myeloid, Acute (11) · Hematologic Neoplasms (9) · Leukemia (9) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (9) · Hodgkin Disease (8) · Lymphoma (8) · Lymphoma, Non-Hodgkin (8) · Myelodysplastic Syndromes (8) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (5) · Anemia, Aplastic (4) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Leukemia, Myelomonocytic, Juvenile (4) · Neuroblastoma (4) · Bone Marrow Failure Disorders (3) · Immunologic Deficiency Syndromes (3)
St. Jude Children's Research Hospital (20) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (6) · Children's Hospital of Philadelphia (3) · Asan Medical Center (1) · Baptist Health South Florida (1) · Baylor College of Medicine (1) · Center for International Blood and Marrow Transplant Research (1) · Julie-An M. Talano (1) · Memorial Sloan Kettering Cancer Center (1) · Timothy Olson (1) · University of Miami (1) · Washington University School of Medicine (1)
United States (37) · Canada (1) · Singapore (1) · South Korea (1)
Brandon Triplett, MD (5) · Neal Flomenberg, MD (5) · Dolores Grosso, DNP, CRNP (3) · Timothy Olson, MD, PhD (3) · Aimee C. Talleur, MD (2) · Brandon M. Triplett, MD (2) · Stephen Gottschalk, MD (2) · Akshay Sharma, MBBS (1) · Amr Qudeimat, MD (1) · Brando Triplett, MD (1) · David Shook, MD (1) · Erin Morales, MD (1) · Ewelina Mamcarz, MD (1) · Gary Kleiner, MDPhD (1) · Guenther Koehne, MD (1)
PMID 23416852, PMID 30894213, PMID 30995372, PMID 31246522, PMID 31765697, PMID 32221013, PMID 34871104, PMID 35446934, PMID 38937803
P01HL053749 (1), R01CA113482 (1), R01CA115422 (1), R01CA132946 (1), R01CA138744 (1)