16 completed, 16 recruiting, 12 active not recruiting, 5 terminated. 59 Phase 2, 15 Phase 1, 3 Phase 3.
Follow Calcium Folinate: new trials by email Literature Review of Calcium Folinate trials Research Report on Calcium Folinate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FOLFOX8 Versus mFOLFOX6 With Bevacizumab or Cetuximab for First-Line Unresectable Metastatic Colorectal Cancer (Phase II) Oxaliplatin, 5-Fluorouracil, Levofolinic Acid For Injection - Metastatic Colorectal Cancer (CRC) | Phase 2 | Not yet recruiting | Sun Yat-sen University | 229 | 2026-11-01 | 2026-10-16 |
| Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Not yet recruiting | SWOG Cancer Research Network | 90 | 2026-10-14 | 2026-10-13 |
| DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic Cancer Biospecimen Collection, Computed Tomography, Dynamic Contrast-Enhanced Magnetic Resonance Imaging - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2026-10-01 | 2026-10-05 |
| Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases Cancer Abemaciclib, Oxaliplatin, Calcium Folinate - Liver Metastases From Colorectal Cancer (mCRC) | Phase 2 | Enrolling by invitation | Fudan University | 16 | 2026-07-30 | 2026-07-22 |
| A Placebo-controlled Trial of Folinic Acid in Children With ASD Folinic Acid, Placebo - Autism Spectrum Disorder | Phase 2 | Recruiting | Prof. Adi Aran | 150 | 2026-06-23 | 2026-06-22 |
| NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial Biospecimen Collection, Computed Tomography, Fluorouracil - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 20 | 2026-03-02 | 2026-09-21 |
| Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Pancreatic Ductal Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 35 | 2026-02-16 | 2026-08-19 |
| A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma Rituximab, Methotrexate, Procarbazine - Lymphoma | Phase 2 | Recruiting | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | 65 | 2025-11-06 | 2026-09-30 |
| Irinotecan Liposome II + 5-FU/LV + Oxaliplatin + Karelizumab in Neoadjuvant Treatment of Gastric Cancer Irinotecan Liposomal - Gastric Cancer | Phase 2 | Not yet recruiting | The First Affiliated Hospital of Zhengzhou University | 33 | 2025-08-15 | 2025-07-31 |
| A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma Sonesitatug Vedotin, Rilvegostomig, Trastuzumab Deruxtecan (T-DXd) - Gastroesophageal Adenocarcinoma | Phase 2 | Recruiting | AstraZeneca | 100 | 2025-07-17 | 2026-11-03 |
| FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery Balstilimab, Biospecimen Collection, Botensilimab - Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8 | Phase 2 | Recruiting | City of Hope Medical Center | 26 | 2025-05-20 | 2026-06-29 |
| Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer DR30206, Oxaliplatin, Capecitabine - Gastrointestinal Cancer | Phase 1 / Phase 2 | Recruiting | Zhejiang Doer Biologics Co., Ltd. | 186 | 2025-03-25 | 2026-06-30 |
| Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC Adebrelimab, Irinotecan liposomes, Lenvatinib - Intrahepatic Cholangiocarcinoma (Icc) | Phase 2 | Not yet recruiting | Harbin Medical University | 68 | 2024-10-01 | 2024-10-18 |
| Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) Pembrolizumab, Sacituzumab Tirumotecan (sac-TMT), Capecitabine - Gastroesophageal Junction, Gastroesophageal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 160 | 2024-09-20 | 2026-10-07 |
| A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients SSGJ-707, Bevacizumab, Oxaliplatin - Metastatic Colorectal Cancer | Phase 2 | Recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 130 | 2024-09-03 | 2024-09-19 |
| Adebelimab Combined With Irinotecan Liposomal Injection, Oxaliplatin, Fluorouracil and Calcium Folinate Are Used in the First-line Treatment of Pancreatic Cancer Liver Metastasis Efficacy and Safety Irinotecan liposome, Adebrelimab, Oxaliplatin - Pancreatic Cancer Metastatic to Liver | Phase 2 | Recruiting | Jiang Long | 40 | 2024-07-16 | 2024-07-31 |
| Adebrelimab in Combination With NALIRIFOX in Locally Advanced Pancreatic Cancer Adebrelimab, Oxaliplatin 100 MG, Irinotecan liposome - Pancreatic Cancer | Phase 2 | Unknown | Fudan University | 87 | 2024-06-05 | 2024-08-09 |
| Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial) Binimetinib, Biopsy Procedure, Biospecimen Collection - Advanced Biliary Tract Carcinoma, Advanced Gallbladder Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 17 | 2024-02-09 | 2026-10-19 |
| Liposomal Irinotecan and Leucovorin/5-fluorouracil Plus Bevacizumab in Metastatic Colorectal Cancer liposomal irinotecan, 5-FU, LV - Colorectal Cancer | Phase 2 | Recruiting | Hebei Medical University Fourth Hospital | 173 | 2024-01-01 | 2024-10-09 |
| Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer Atezolizumab, Biospecimen Collection, Capecitabine - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 2 | 2023-12-06 | 2026-07-01 |
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Colorectal Neoplasms (11) · Pancreatic Neoplasms (10) · Burkitt Lymphoma (6) · Rectal Neoplasms (5) · Stomach Neoplasms (5) · Esophageal Neoplasms (4) · Adenocarcinoma Of Esophagus (3) · Cholangiocarcinoma (3) · Colonic Neoplasms (3) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (3) · Gallbladder Neoplasms (2) · Gastrointestinal Neoplasms (2) · Klatskin Tumor (2) · Leukemia, Biphenotypic, Acute (2) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (2)
National Cancer Institute (NCI) (10) · City of Hope Medical Center (4) · Roswell Park Cancer Institute (3) · Fudan University (2) · M.D. Anderson Cancer Center (2) · Mayo Clinic (2) · SWOG Cancer Research Network (2) · University of Nebraska (2) · Academic and Community Cancer Research United (1) · Akeso (1) · Albert Einstein College of Medicine (1) · AstraZeneca (1) · Barbara Ann Karmanos Cancer Institute (1) · Bristol-Myers Squibb (1) · Children's Oncology Group (1)
United States (41) · China (13) · Canada (5) · Puerto Rico (5) · France (3) · Germany (3) · Spain (3) · Australia (2) · Italy (2) · Japan (2) · Norway (2) · Poland (2) · Taiwan (2) · United Kingdom (2) · Brazil (1)
Christos Fountzilas (2) · Elias Jabbour (2) · Marwan Fakih (2) · Anthony Shields (1) · Ardaman Shergill (1) · Charles D Lopez (1) · Chi Lin (1) · Christopher L. Hallemeier, MD (1) · Darren Feldman (1) · David Bajor, MD (1) · Efrat Dotan (1) · Elena G Chiorean (1) · Farhad Ravandi-Kashani (1) · Feng Wang (1)
PMID 25926352, PMID 29618479, PMID 29812996, PMID 32939319, PMID 33242441, PMID 34492682, PMID 35007127, PMID 35622074, PMID 36221952, PMID 36963200, PMID 38084840, PMID 38485190, PMID 38867582, PMID 41133726, PMID 41671463
U10CA180888 (5), U10CA180820 (3), P30CA033572 (2), P30CA036727 (2), U10CA032102 (2), U10CA180821 (2), U10CA180886 (2), 2017 (1), 2019 (1), 2023 (1), 2025 (1), N01CM00071 (1), N01CM62206 (1), P30CA008748 (1), P30CA013330 (1)