40 completed, 28 recruiting, 25 active not recruiting, 11 terminated. 59 Phase 2, 37 Phase 3, 35 Phase 1, 3 Early Phase 1, 1 Not applicable.
Follow Calcium Folinate: new trials by email Literature Review of Calcium Folinate trials Research Report on Calcium Folinate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| FOLFOX8 Versus mFOLFOX6 With Bevacizumab or Cetuximab for First-Line Unresectable Metastatic Colorectal Cancer (Phase II) Oxaliplatin, 5-Fluorouracil, Levofolinic Acid For Injection - Metastatic Colorectal Cancer (CRC) | Phase 2 | Not yet recruiting | Sun Yat-sen University | 229 | 2026-11-01 | 2026-10-16 |
| Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Not yet recruiting | SWOG Cancer Research Network | 90 | 2026-10-14 | 2026-10-13 |
| DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic Cancer Biospecimen Collection, Computed Tomography, Dynamic Contrast-Enhanced Magnetic Resonance Imaging - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2026-10-01 | 2026-10-05 |
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2026-10-01 | 2026-09-25 |
| Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases Cancer Abemaciclib, Oxaliplatin, Calcium Folinate - Liver Metastases From Colorectal Cancer (mCRC) | Phase 2 | Enrolling by invitation | Fudan University | 16 | 2026-07-30 | 2026-07-22 |
| A Placebo-controlled Trial of Folinic Acid in Children With ASD Folinic Acid, Placebo - Autism Spectrum Disorder | Phase 2 | Recruiting | Prof. Adi Aran | 150 | 2026-06-23 | 2026-06-22 |
| Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon Cancer Cadonilimab (AK104), Oxaliplatin, Capecitabine - Resectable Colon Cancer, MSI-H/dMMR Colorectal Cancer | Phase 3 | Recruiting | Akeso | 386 | 2026-04-15 | 2026-04-22 |
| NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial Biospecimen Collection, Computed Tomography, Fluorouracil - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 20 | 2026-03-02 | 2026-09-21 |
| Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Pancreatic Ductal Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 35 | 2026-02-16 | 2026-08-19 |
| A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors PF-08032562, Fulvestrant, Cetuximab - Advanced Breast Cancer, Metastatic Breast Cancer (HR+/ HER2-) | Phase 1 | Recruiting | Pfizer | 260 | 2025-12-23 | 2026-07-22 |
| Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic Cancer GFH375, Chemotherapy - Metastatic Pancreatic Cancer | Phase 3 | Recruiting | Genfleet Therapeutics (Shanghai) Inc. | 320 | 2025-12-04 | 2026-08-14 |
| A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma Rituximab, Methotrexate, Procarbazine - Lymphoma | Phase 2 | Recruiting | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | 65 | 2025-11-06 | 2026-09-30 |
| Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Capecitabine - Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 356 | 2025-08-21 | 2026-08-25 |
| Irinotecan Liposome II + 5-FU/LV + Oxaliplatin + Karelizumab in Neoadjuvant Treatment of Gastric Cancer Irinotecan Liposomal - Gastric Cancer | Phase 2 | Not yet recruiting | The First Affiliated Hospital of Zhengzhou University | 33 | 2025-08-15 | 2025-07-31 |
| A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma Sonesitatug Vedotin, Rilvegostomig, Trastuzumab Deruxtecan (T-DXd) - Gastroesophageal Adenocarcinoma | Phase 2 | Recruiting | AstraZeneca | 100 | 2025-07-17 | 2026-10-16 |
| Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Colorectal Adenocarcinoma, Stage III Colorectal Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 24 | 2025-06-23 | 2026-09-09 |
| FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery Balstilimab, Biospecimen Collection, Botensilimab - Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8 | Phase 2 | Recruiting | City of Hope Medical Center | 26 | 2025-05-20 | 2026-06-29 |
| A Comparative Study of Pharmacokinetics, Safety, and Immunogenicity of RPH-030 and Vectibix® in Patients With Metastatic Colorectal Cancer With Wild-type RAS as First-line Therapy in Combination With FOLFIRI RPH-030, Vectibix®, Irinotecan - Metastatic Colorectal Cancer | Phase 1 | Recruiting | R-Pharm | 180 | 2025-04-17 | 2026-04-22 |
| Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer DR30206, Oxaliplatin, Capecitabine - Gastrointestinal Cancer | Phase 1 / Phase 2 | Recruiting | Zhejiang Doer Biologics Co., Ltd. | 186 | 2025-03-25 | 2026-06-30 |
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Colorectal Neoplasms (27) · Pancreatic Neoplasms (14) · Burkitt Lymphoma (13) · Colonic Neoplasms (13) · Rectal Neoplasms (12) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (10) · Stomach Neoplasms (9) · Adenocarcinoma Of Esophagus (6) · Esophageal Neoplasms (6) · Leukemia, Biphenotypic, Acute (5) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (5) · Carcinoma, Non-Small-Cell Lung (4) · Esophageal Squamous Cell Carcinoma (4) · Parkinson Disease 4, Autosomal Dominant Lewy Body (4) · Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (4)
National Cancer Institute (NCI) (22) · Children's Oncology Group (10) · City of Hope Medical Center (7) · Merck Sharp & Dohme LLC (4) · Pfizer (4) · M.D. Anderson Cancer Center (3) · Mayo Clinic (3) · NRG Oncology (3) · Roswell Park Cancer Institute (3) · Akeso (2) · Alliance for Clinical Trials in Oncology (2) · Bristol-Myers Squibb (2) · ECOG-ACRIN Cancer Research Group (2) · Fudan University (2) · Jonsson Comprehensive Cancer Center (2)
United States (88) · Canada (26) · China (21) · Australia (18) · Puerto Rico (17) · New Zealand (12) · Germany (9) · France (7) · Switzerland (7) · Italy (6) · United Kingdom (6) · Japan (5) · Russia (5) · South Korea (5) · Spain (5)
Christos Fountzilas (2) · Elias Jabbour (2) · Marwan Fakih (2) · Marwan G Fakih (2) · Zev A Wainberg (2) · Afsaneh Barzi, MD (1) · Alan Venook, MD (1) · Alexandra M Stevens (1) · Alyssa T Reddy (1) · Andrea Biondi (1) · Anne L Angiolillo (1) · Anne M Noonan, MBBChBAO, MSc (1)
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