14 completed, 9 recruiting, 7 active not recruiting, 3 terminated. 35 Phase 1, 15 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 35 | Completed 14, Recruiting 9, Active not recruiting 7, Terminated 3, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 15 | Completed 6, Recruiting 5, Active not recruiting 3, Unknown 1 |
Follow Calcium Folinate: new trials by email Literature Review of Calcium Folinate trials Research Report on Calcium Folinate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic Cancer Biospecimen Collection, Computed Tomography, Dynamic Contrast-Enhanced Magnetic Resonance Imaging - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2026-10-01 | 2026-10-05 |
| Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Pancreatic Ductal Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 35 | 2026-02-16 | 2026-08-19 |
| A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors PF-08032562, Fulvestrant, Cetuximab - Advanced Breast Cancer, Metastatic Breast Cancer (HR+/ HER2-) | Phase 1 | Recruiting | Pfizer | 260 | 2025-12-23 | 2026-07-22 |
| Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Colorectal Adenocarcinoma, Stage III Colorectal Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 24 | 2025-06-23 | 2026-09-09 |
| A Comparative Study of Pharmacokinetics, Safety, and Immunogenicity of RPH-030 and Vectibix® in Patients With Metastatic Colorectal Cancer With Wild-type RAS as First-line Therapy in Combination With FOLFIRI RPH-030, Vectibix®, Irinotecan - Metastatic Colorectal Cancer | Phase 1 | Recruiting | R-Pharm | 180 | 2025-04-17 | 2026-04-22 |
| Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer DR30206, Oxaliplatin, Capecitabine - Gastrointestinal Cancer | Phase 1 / Phase 2 | Recruiting | Zhejiang Doer Biologics Co., Ltd. | 186 | 2025-03-25 | 2026-06-30 |
| A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Myelodysplastic Syndrome | Phase 1 | Recruiting | Children's Oncology Group | 36 | 2025-02-04 | 2026-08-25 |
| A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene. PF-07985045, Gemcitabine, Nab-paclitaxel - Carcinoma, Pancreatic Ductal, Colorectal Neoplasms | Phase 1 | Terminated | Pfizer | 30 | 2024-12-10 | 2026-05-22 |
| A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors BMS-986484, Nivolumab, Oxaliplatin - Advanced Solid Tumors | Phase 1 | Active not recruiting | Bristol-Myers Squibb | 213 | 2024-10-10 | 2026-04-17 |
| Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) Pembrolizumab, Sacituzumab Tirumotecan (sac-TMT), Capecitabine - Gastroesophageal Junction, Gastroesophageal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 160 | 2024-09-20 | 2026-10-07 |
| A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation. PF-07934040, Gemcitabine, Nab-paclitaxel - Carcinoma, Pancreatic Ductal, Colorectal Neoplasms | Phase 1 | Active not recruiting | Pfizer | 64 | 2024-06-27 | 2026-10-13 |
| Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis Aldesleukin, Biopsy Procedure, Biospecimen Collection - Clinical Stage IV Gastric Cancer AJCC v8, Gastric Adenocarcinoma | Phase 1 | Active not recruiting | Mayo Clinic | 15 | 2023-11-29 | 2026-07-01 |
| A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer AK119, AK112, Oxaliplatin - Colorectal Cancer | Phase 1 / Phase 2 | Active not recruiting | Akeso | 170 | 2023-05-08 | 2026-03-04 |
| FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer Balstilimab, Bevacizumab, Biospecimen Collection - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 / Phase 2 | Active not recruiting | City of Hope Medical Center | 20 | 2023-05-03 | 2026-09-01 |
| Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma Biospecimen Collection, Computed Tomography, Core Biopsy - Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 56 | 2023-03-07 | 2026-10-29 |
| Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer Gemcitabine Hydrochloride, Nab-paclitaxel, Fluorouracil - Locally Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Active not recruiting | Flemming Forsberg | 120 | 2021-12-06 | 2025-11-04 |
| Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines Biopsy Procedure, Biospecimen Collection, Diagnostic Imaging Testing - Advanced Colorectal Carcinoma, Advanced Digestive System Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 10 | 2021-08-13 | 2026-08-21 |
| Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Bevacizumab, Fluorouracil, Leucovorin Calcium - Metastatic Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8 | Phase 1 | Completed | Ning Jin | 13 | 2021-04-02 | 2025-03-28 |
| Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab Bevacizumab, Dasatinib, Fluorouracil - Advanced Colorectal Carcinoma, Metastatic Colorectal Carcinoma | Phase 1 | Completed | Anne Noonan | 9 | 2020-09-02 | 2024-12-27 |
Showing 20 of 35. Sign in to see all of them.
Colorectal Neoplasms (14) · Colonic Neoplasms (8) · Rectal Neoplasms (7) · Pancreatic Neoplasms (5) · Stomach Neoplasms (5) · Carcinoma, Non-Small-Cell Lung (4) · Esophageal Neoplasms (3) · Gastrointestinal Neoplasms (3) · Lung Neoplasms (3) · Carcinoma, Pancreatic Ductal (2) · Parkinson Disease 4, Autosomal Dominant Lewy Body (2) · Spinocerebellar Degenerations (2) · Triple Negative Breast Neoplasms (2) · Adenocarcinoma Of Esophagus (1) · Bile Duct Neoplasms (1)
City of Hope Medical Center (4) · National Cancer Institute (NCI) (4) · Pfizer (3) · Mayo Clinic (2) · Merck Sharp & Dohme LLC (2) · Academic and Community Cancer Research United (1) · Akeso (1) · Anne Noonan (1) · Barbara Ann Karmanos Cancer Institute (1) · Bristol-Myers Squibb (1) · Children's Oncology Group (1) · David Bajor, MD (1) · Flemming Forsberg (1) · GlaxoSmithKline (1) · Isofol Medical AB (1)
United States (30) · China (3) · Australia (2) · Canada (2) · Norway (2) · Puerto Rico (2) · Brazil (1) · Chile (1) · Czechia (1) · France (1) · Germany (1) · Hungary (1) · Italy (1) · Poland (1) · Russia (1)
Marwan G Fakih (2) · Alexandra M Stevens (1) · Anne M Noonan, MBBChBAO, MSc (1) · Anthony Shields (1) · Aung Naing, MD (1) · Christos Fountzilas (1) · David Bajor, MD (1) · Flemming Forsberg, PhD (1) · Harry H. Yoon, M.D. (1) · Heinz-Josef Lenz (1) · Jeffrey Wong, MD (1)
PMID 32939319, PMID 33142018, PMID 33909232, PMID 34562230, PMID 34965890, PMID 37129197, PMID 38084840, PMID 38653648, PMID 38762348, PMID 39816915, PMID 39841295, PMID 39945382, PMID 41133726
P30CA015083 (2), P30CA033572 (2), UM1CA186689 (2), 2019 (1), 2023 (1), 2025 (1), P30CA016359 (1), P30CA022453 (1), P30CA069533 (1), R01CA131225 (1), R01CA199646 (1), R01CA290435 (1), U01CA069912 (1), UM1CA186686 (1), UM1CA186690 (1)