12 completed, 3 terminated, 1 unknown. 4 Phase 2, 3 Not applicable, 3 Phase 1, 3 Phase 4, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Not applicable | 3 | Completed 2, Unknown 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 4 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
| Early Phase 1 | 1 | Terminated 1 |
Follow Bupropion Hydrochloride: new trials by email Literature Review of Bupropion Hydrochloride trials Research Report on Bupropion Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High Dose Bupropion for Smoking Cessation - Pilot Study Bupropion Hydrochloride - Smoking Cessation, Smoking, Tobacco | Phase 2 | Terminated | University of Southern California | 12 | 2021-09-01 | 2023-07-17 |
| A Study in Healthy Men and Women to Test Whether BI 1358894 Influences the Amount of Bupropion in the Blood Elontril, BI 1358894 - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 18 | 2021-06-30 | 2025-02-24 |
| Study of ALXN1840 on the Metabolism of a CYP2B6 Substrate in Healthy Participants ALXN1840, Bupropion Hydrochloride - Wilson Disease | Phase 1 | Completed | Alexion Pharmaceuticals, Inc. | 54 | 2020-10-21 | 2023-08-31 |
| Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic Cancer Bupropion 150 mg XL, Placebo - Breast Carcinoma, Cervical Carcinoma | Phase 2 | Completed | NRG Oncology | 230 | 2017-05-31 | 2026-07-10 |
| Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Bupropion Hydrochloride, Laboratory Biomarker Analysis, Nicotine Replacement - Current Smoker, Head and Neck Squamous Cell Carcinoma | Early Phase 1 | Terminated | Wake Forest University Health Sciences | 9 | 2016-01-01 | 2023-03-22 |
| Smoking Cessation for People Living With HIV/AIDS Bupropion, Brief Counseling, High-magnitude prize contingency management - HIV, AIDS | Not applicable | Unknown | Wayne State University | 165 | 2013-08-01 | 2021-07-02 |
| Drug Interaction Study of Multiple Doses of Isavuconazole and a Single Dose of Bupropion Isavuconazole, bupropion hydrochloride - Pharmacokinetics of Isavuconazole, Pharmacokinetics of Bupropion | Phase 1 | Completed | Astellas Pharma Global Development, Inc. | 24 | 2012-06-01 | 2015-09-01 |
| Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders. placebo, varenicline tartrate, bupropion hydrochloride - Smoking Cessation | Phase 4 | Completed | Pfizer | 4595 | 2012-05-01 | 2016-12-29 |
| Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders Placebo, varenicline tartrate, bupropion hydrochloride - Smoking Cessation | Phase 4 | Completed | Pfizer | 8144 | 2011-11-01 | 2016-06-10 |
| Effect of Smoking Cessation on Clinical and Microbiological Outcomes of the Non-surgical Periodontal Therapy Smoking cessation counseling, Non-surgical periodontal therapy, Nicotine replacement therapy - Periodontitis | Not applicable | Completed | Claudio Mendes Pannuti | 63 | 2010-08-01 | 2018-11-06 |
| Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking smoking cessation intervention, bupropion hydrochloride, gene expression analysis - Bladder Cancer, Cervical Cancer | Phase 4 | Completed | Lisa Sanderson Cox, PhD | 540 | 2007-12-01 | 2017-11-13 |
| Bupropion in Helping Adults Stop Smoking bupropion hydrochloride, placebo - Bladder Cancer, Cervical Cancer | Phase 2 | Completed | Roswell Park Cancer Institute | 95 | 2006-01-01 | 2017-05-30 |
| Study Of 323U66 SR In Major Depressive Disorder bupropion hydrochloride - Depressive Disorder | Phase 2 | Completed | GlaxoSmithKline | 234 | 2004-12-01 | 2019-02-01 |
| Bupropion and Counseling With or Without Contingency Management to Enhance Smoking Cessation in Treating Cancer Survivors Who Continue to Smoke smoking cessation intervention, bupropion hydrochloride - Cancer Survivor, Unspecified Adult Solid Tumor, Protocol Specific | Not applicable | Completed | National Institutes of Health Clinical Center (CC) | 2004-02-01 | 2012-03-08 | |
| Comparison of Nicotine Inhaler and/or Bupropion in Helping People to Stop Smoking and Prevent the Recurrence of Smoking placebo, bupropion hydrochloride, nicotine - Lung Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 1708 | 2002-02-01 | 2016-07-13 |
| S0002 - A Program to Quit Smoking With or Without Bupropion in Treating Patients With Stage I or II Non-Small Cell Lung Cancer Who Have Undergone Surgery smoking cessation intervention, bupropion hydrochloride, nicotine - Lung Cancer | Phase 3 | Terminated | SWOG Cancer Research Network | 10 | 2002-01-01 | 2013-03-11 |
Smoking Cessation (5) · Carcinoma, Non-Small-Cell Lung (4) · Lung Neoplasms (4) · Small Cell Lung Carcinoma (3) · Tobacco Use Disorder (3) · Uterine Cervical Neoplasms (3) · Carcinoma, Hepatocellular (2) · Carcinoma, Renal Cell (2) · Esophageal Neoplasms (2) · Head and Neck Neoplasms (2) · Hypopharyngeal Neoplasms (2) · Kidney Neoplasms (2) · Laryngeal Neoplasms (2) · Leukemia (2) · Leukemia, Myeloid, Acute (2)
Pfizer (2) · Alexion Pharmaceuticals, Inc. (1) · Alliance for Clinical Trials in Oncology (1) · Astellas Pharma Global Development, Inc. (1) · Boehringer Ingelheim (1) · Claudio Mendes Pannuti (1) · GlaxoSmithKline (1) · Lisa Sanderson Cox, PhD (1) · NRG Oncology (1) · National Institutes of Health Clinical Center (CC) (1) · Roswell Park Cancer Institute (1) · SWOG Cancer Research Network (1) · University of Southern California (1) · Wake Forest University Health Sciences (1) · Wayne State University (1)
United States (13) · Canada (3) · Germany (3) · Argentina (2) · Australia (2) · Brazil (2) · Bulgaria (2) · Chile (2) · Denmark (2) · Finland (2) · Mexico (2) · New Zealand (2) · Russia (2) · Slovakia (2) · South Africa (2)
Adam M Leventhal, PhD (1) · Claudio M Pannuti, PhD (1) · David Ledgerwood, PhD (1) · Debra Barton (1) · Ellen R. Gritz, PhD (1) · Glen D. Morgan, PhD (1) · James Stevenson, MD (1) · Lisa S. Cox, PhD (1) · Martin Mahoney, MD (1) · Mercedes Porosnicu (1) · Philip C. Hoffman, MD (1) · Richard D. Hurt, MD (1)
PMID 37230961, PMID 21266057, PMID 21775497, PMID 22241828, PMID 23733379, PMID 24794687, PMID 27116918, PMID 29508470, PMID 29630702, PMID 30847828, PMID 31195244, PMID 31850603, PMID 33138708, PMID 33300144, PMID 33464316, PMID 33605440, PMID 33788933, PMID 33885203, PMID 34112520, PMID 34481605, PMID 34611902, PMID 34791718, PMID 34882500, PMID 35535436, PMID 35611069, PMID 39306350, PMID 39404754
P30CA012197 (1), R01CA091912 (1), R01DA034537 (1), UG1CA189867 (1)