8 completed, 6 unknown, 2 active not recruiting, 2 recruiting. 19 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 19 | Completed 8, Unknown 6, Active not recruiting 2, Recruiting 2, Terminated 1 |
Follow Botulinum Toxins: new trials by email Literature Review of Botulinum Toxins trials Research Report on Botulinum Toxins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities Cryoneurolysis, Botulinum toxin - Centreal Neurological Condition, Acquired Brain Injury (Including Stroke) | Phase 4 | Recruiting | Oxford University Hospitals NHS Trust | 50 | 2025-12-02 | 2025-12-26 |
| EMG-Based Evaluation of Occlusal Splint and Masseter Botox Effects on Head and Neck Muscles Botulinum toxin injection, Occlusal splint, Botulinum toxin + Occlusal splint combined - Myofascial Pain Syndrome (MPS), Masticatory Muscle Pain | Phase 4 | Recruiting | Istanbul University | 56 | 2025-09-01 | 2025-07-24 |
| Factors Determining the Efficacy of Botulinum Toxin for Arm Tremor in Dystonia Polymyography, Muscle ultrasound, (Functional) magnetic resonance imaging - Dystonic Tremor Syndrome | Phase 4 | Active not recruiting | Radboud University Medical Center | 60 | 2025-01-01 | 2026-08-14 |
| Effect of Topical Botulinum Toxin Eyedrop on Palpebral Fissure Botulinum toxin - Tears; Excess, Eyelid Spasm | Phase 4 | Terminated | University of Miami | 2 | 2022-11-29 | 2024-12-05 |
| Botulinum Toxin in Raynaud's Phenomenon Botulinum toxin - Raynaud Phenomenon | Phase 4 | Completed | Emory University | 24 | 2022-02-10 | 2026-07-29 |
| Same-Day Combination of VI Peel and Botox for Correction of Sun Damage, Fine Lines and Wrinkles Same Day Intervention of VI Peel (Procedure) and Botulinum Toxin (Drug) - Photoaging, Wrinkle | Phase 4 | Completed | Vitality Institute Medical Products | 30 | 2021-12-08 | 2022-04-25 |
| Assessment of Pain After Intra-articular Botulinum Toxin Injections in Carpometacarpal Osteoarthritis of the Thumb Botulinum toxin, Placebo - Rhizarthrosis | Phase 4 | Active not recruiting | Centre Hospitalier Universitaire de Nice | 60 | 2021-09-09 | 2025-12-03 |
| Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings Botulinum neurotoxin (BTX), Physical Therapy, Standard BTX injection (ultrasound guided) - Spasticity | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 17 | 2017-11-21 | 2020-11-05 |
| Botulinum Toxin to Improve Lower Blepharoplasty Scar Botulinum Toxin, Normal Saline - Other Degenerative Disorders of Eyelid and Periocular Area | Phase 4 | Unknown | Chang Gung Memorial Hospital | 40 | 2016-06-01 | 2016-06-23 |
| Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster Azzalure, Restylane/Emervel filler, Restylane Skinbooster - Facial Aesthetic Treatment | Phase 4 | Completed | Galderma R&D | 61 | 2014-11-01 | 2022-08-26 |
| Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment Azzalure or Dysport, Restylane or Emervel filler, Restylane Skinbooster - Aesthetics | Phase 4 | Completed | Galderma R&D | 65 | 2014-11-01 | 2022-10-14 |
| Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation Botulinum Toxin, Anal Myectomy - Chronic Idiopathic Constipation, Functional Constipation | Phase 4 | Unknown | Cairo University | 40 | 2014-09-01 | 2018-01-30 |
| The Use of Botox in Advanced Parkinson's Patients Experiencing Pain Botulinum Toxin - Parkinson's Disease | Phase 4 | Unknown | University Health Network, Toronto | 14 | 2014-07-01 | 2015-06-26 |
| Propranolol and Botulinum Toxin for Essential Vocal Tremor Propranolol, Botulinum Toxin - Essential Vocal Tremor, Essential Voice Tremor | Phase 4 | Completed | Emory University | 18 | 2014-05-01 | 2016-04-27 |
| Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke Tenotomy of the proximal rectus femoris tendon, Botulinum Toxin injection in the rectus femoris muscle - Stroke, Spasticity | Phase 4 | Unknown | University Hospital of Mont-Godinne | 20 | 2014-03-01 | 2014-04-15 |
| Botulinum Toxin in the Treatment of Idiopathic Detrusor Overactivity Botulinum toxin injected to bladder body, Botulinum toxin injected into trigone - Overactive Detrusor | Phase 4 | Unknown | Mr HD Flood | 60 | 2013-12-01 | 2013-12-12 |
| Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex Xeomin® - Cervical Dystonia | Phase 4 | Completed | Merz Pharmaceuticals GmbH | 283 | 2012-01-20 | 2022-10-27 |
| Safety and Efficacy of the Full Face Applications of Variable Doses of a Commercial Botulinum Toxin Type a (Dysport®) Botulinum toxin - Sun-induced Wrinkles | Phase 4 | Completed | Hexsel Dermatology Clinic | 90 | 2009-11-01 | 2020-10-14 |
| Botox on Vulvar Vestibulitis Botulinum toxin - Vulvar Vestibulitis, Vulvar Diseases | Phase 4 | Unknown | Copenhagen University Hospital, Rigshospitalet | 64 | 2005-04-01 | 2007-04-19 |
Muscle Spasticity (3) · Stroke (3) · Blepharospasm (1) · Brain Injuries (1) · Bruxism (1) · Cicatrix (1) · Dystonia (1) · Essential Tremor (1) · Lacerations (1) · Multiple Sclerosis (1) · Myofascial Pain Syndromes (1) · Pain (1) · Parkinson Disease (1) · Raynaud Disease (1) · Spinal Cord Injuries (1)
Emory University (2) · Galderma R&D (2) · Cairo University (1) · Centre Hospitalier Universitaire de Nice (1) · Chang Gung Memorial Hospital (1) · Copenhagen University Hospital, Rigshospitalet (1) · Hexsel Dermatology Clinic (1) · Istanbul University (1) · Merz Pharmaceuticals GmbH (1) · Mr HD Flood (1) · Oxford University Hospitals NHS Trust (1) · Radboud University Medical Center (1) · The University of Texas Health Science Center, Houston (1) · University Health Network, Toronto (1) · University Hospital of Mont-Godinne (1)
United States (6) · France (3) · Brazil (2) · Sweden (2) · Belgium (1) · Denmark (1) · Egypt (1) · Ireland (1) · Netherlands (1) · Taiwan (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Philippe Kestemont, MD (2) · Anke Snijders, PhD (1) · Christina Damsted Petersen, MD (1) · Doris M Hexsel, MD (1) · H D Flood, FRCSI (1) · Henry Yau-Li Huang, M.D. (1) · Michael Johns, MD (1) · Michael Kulagowski, MD (1) · Mohamed Seoudi (1) · Paul A Ghareeb, MD (1) · Pierre Blanc (1) · Sheng Li, MD, PhD (1) · Thierry Deltombe, M.D. (1) · Wendy E Roberts, MD (1)