10 completed, 4 recruiting, 2 active not recruiting, 2 enrolling by invitation. 16 Not applicable, 6 Phase 1, 5 Phase 2.
Follow Acute Intermittent Hypoxia: new trials by email Literature Review of Acute Intermittent Hypoxia trials Research Report on Acute Intermittent Hypoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury Istradefylline, low oxygen therapy - Spinal Cord Injuries, Myelopathy | Phase 1 / Phase 2 | Not yet recruiting | Randy Trumbower, PT, PhD | 40 | 2027-09-01 | 2026-03-20 |
| Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Living With MS Acute Intermittent Hypoxia - Multiple Sclerosis | Phase 1 / Phase 2 | Not yet recruiting | University of Saskatchewan | 9 | 2026-07-01 | 2026-06-05 |
| Non-invasive Therapy to Drive Nerve Regeneration Acute Intermittent Hypoxia, Normoxia - Peripheral Nerve Injuries | Not applicable | Enrolling by invitation | University of Alberta | 80 | 2025-07-01 | 2026-02-09 |
| Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS Acute Intermittent Hypoxia, Sham Acute Intermittent Hypoxia - Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting | Not applicable | Recruiting | Shirley Ryan AbilityLab | 22 | 2025-02-01 | 2026-02-23 |
| The Synergistic Effects of AIH and FES in Persons With MS Acute Intermittent Hypoxia, Neuromuscular Electrical Stimulation - Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting | Not applicable | Active not recruiting | Shirley Ryan AbilityLab | 40 | 2024-11-01 | 2026-02-23 |
| Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog Acute Placebo Visit, Acute Progressive Carbon Dioxide, Acute Intermittent Hypoxia - Long COVID | Not applicable | Recruiting | Mayo Clinic | 45 | 2024-09-24 | 2026-06-05 |
| Intermittent Hypoxia in Persons With Multiple Sclerosis Acute Intermittent Hypoxia, Sham-Acute Intermittent Hypoxia - Multiple Sclerosis, Multiple Sclerosis-Relapsing-Remitting | Not applicable | Recruiting | Shirley Ryan AbilityLab | 21 | 2024-04-30 | 2026-03-20 |
| Adenosine 2A Receptor Antagonism and AIH in ALS Consume 20mg of istradefylline, Low Oxygen therapy, Placebo counterpart to the istradefylline drug - ALS | Phase 1 / Phase 2 | Active not recruiting | University of Florida | 40 | 2022-06-21 | 2026-03-27 |
| The Effect of Acute Intermittent Hypoxia on Motor Learning Acute Intermittent Hypoxia, SHAM Acute Intermittent Hypoxia - Incomplete Spinal Cord Injury | Not applicable | Completed | University of Colorado, Boulder | 56 | 2022-05-27 | 2025-05-14 |
| Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia Acute Intermittent Hypoxia, Sham Acute Intermittent Hypoxia - Healthy Brain Perfusion | Not applicable | Completed | Northwestern University | 33 | 2022-05-03 | 2026-07-20 |
| Acute Intermittent Hypoxia in Traumatic Brain Injury Acute Intermittent Hypoxia - Brain Injuries, Traumatic | Not applicable | Completed | Shirley Ryan AbilityLab | 12 | 2022-03-15 | 2026-02-18 |
| Effects of Acute Intermittent Hypoxia on Brain Function Imaging and Systemic Inflammation acute intermittent hypoxia - Hypoxemia | Not applicable | Unknown | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 15 | 2020-11-01 | 2019-04-09 |
| Enhancing Cognition in Older Adults With Intermittent Hypoxia and Cognitive Training Acute Intermittent Hypoxia, Computerized Cognitive Training - Aging | Not applicable | Completed | University of Florida | 11 | 2019-06-01 | 2022-01-04 |
| Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI Acute Intermittent Hypoxia - Spinal Cord Injuries | Not applicable | Completed | Northwestern University | 43 | 2019-05-20 | 2023-09-28 |
| Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury Caffeine, AIH, Placebo - Spinal Cord Injuries | Phase 1 / Phase 2 | Completed | Spaulding Rehabilitation Hospital | 36 | 2019-01-01 | 2023-12-13 |
| Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease Acute Intermittent Hypoxia, Sham Acute Intermittent Hypoxia - Amyotrophic Lateral Sclerosis (ALS), Neuromuscular Diseases | Not applicable | Completed | University of Florida | 29 | 2018-10-01 | 2025-05-15 |
| Effect of Intermittent Hypoxia in Healthy Individuals Acute Intermittent Hypoxia, Sham Acute Intermittent Hypoxia - Healthy | Not applicable | Enrolling by invitation | Shirley Ryan AbilityLab | 32 | 2016-11-16 | 2026-03-20 |
| Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI Acute Intermittent Hypoxia, Sham Acute Intermittent Hypoxia - Spinal Cord Injuries | Phase 1 / Phase 2 | Unknown | Shirley Ryan AbilityLab | 24 | 2016-05-01 | 2020-02-19 |
| Intermittent Hypoxia and Upper Extremity EMG Recordings in Individuals With Spinal Cord Injury Acute Intermittent Hypoxia - Spinal Cord Injuries | Not applicable | Completed | Shirley Ryan AbilityLab | 8 | 2016-02-03 | 2022-08-24 |
| Acute Intermittent Hypoxia and Body Weight Supported Treadmill Training for Incomplete Spinal Cord Injury Patients Acute Intermittent Hypoxia, Body weight-assisted treadmill training, Sham Protocol - Spinal Cord Injuries | Not applicable | Completed | Sociedad Pro Ayuda del Niño Lisiado | 35 | 2015-03-01 | 2016-05-27 |
Showing 20 of 22. Sign in to see all of them.
Spinal Cord Injuries (9) · Hypoxia (8) · Multiple Sclerosis (4) · Multiple Sclerosis, Chronic Progressive (3) · Multiple Sclerosis, Relapsing-Remitting (3) · Respiratory Aspiration (2) · Amyotrophic Lateral Sclerosis (1) · Brain Injuries, Traumatic (1) · Fatigue (1) · Mental Fatigue (1) · Neuromuscular Diseases (1) · Peripheral Nerve Injuries (1) · Post-Acute COVID-19 Syndrome (1) · Spinal Cord Diseases (1)
Shirley Ryan AbilityLab (7) · University of Florida (3) · Northwestern University (2) · Spaulding Rehabilitation Hospital (2) · Emory University (1) · Mayo Clinic (1) · Randy Trumbower, PT, PhD (1) · Sociedad Pro Ayuda del Niño Lisiado (1) · University of Alberta (1) · University of Colorado, Boulder (1) · University of Saskatchewan (1) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (1)
United States (18) · Canada (1) · Chile (1)
Randy D Trumbower, PT, PhD (4) · Molly G Bright, DPhil (2) · Adam J Woods, PhD (1) · Angela A Navarrete-Opazo, MD, PhD (1) · Barbara K Smith, PT, PhD (1) · Barbara Smith (1) · Courtney Wheatley-Guy (1) · Jordan Grafman, PhD (1) · Milap Sandhu (1) · Milap Sandhu, PhD (1) · Milap Sandhu, Pt, PhD (1) · Song Liu, M.d., Ph.D. (1) · William Rymer, PhD (1) · William Z Rymer, MD, PhD (1)
PMID 24285617, PMID 27702556, PMID 37983629, PMID 38356241, PMID 39058666, PMID 39994358, PMID 40144550, PMID 41202295
R01HD081274 (2), P2CHD086844 (1), R21HD108587 (1), R21NS114815 (1)