116 completed, 46 unknown, 27 recruiting, 8 active not recruiting. 115 Not applicable, 13 Phase 2, 11 Phase 3, 8 Phase 1, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Identifying the Best Follow up Approach for People Who Have Had Treatment to Cure Newly Diagnosed Prostate Cancer Hospital based follow up, Primary care based follow up, Planned shared care follow up - Prostate Cancer | Not yet recruiting | Imperial College London | 100000 | 2026-12-01 | 2026-10-06 | |
| Stopping Strep Throat With Antibodies in Healthy Adults. Streptococcus pyogenes M1 challenge strain, Intravenous immunoglobulin (IVIG), Saline (NaCl 0,9 %) (placebo) - Streptococcal Pharyngitis | Phase 1 | Not yet recruiting | Murdoch Childrens Research Institute | 60 | 2026-10-01 | 2026-10-07 |
| A Pilot Study of the VosCryoTM Breathalyser in Lung Cancer Expiratory Breath Condensate Collection - Advanced Lung Cancer | Not yet recruiting | Sheffield Teaching Hospitals NHS Foundation Trust | 24 | 2026-09-01 | 2026-07-14 | |
| Self-Help Booklets for Sleep in Adults With Pulmonary Hypertension Sleep Hygiene Self-Help Intervention - Pulmonary Hypertension, Insomnia | Not applicable | Not yet recruiting | University of Sheffield | 60 | 2026-09-01 | 2026-08-10 |
| Service Evaluation for Newborn Screening for Spinal Muscular Atrophy Spinal Muscular Atrophy (SMA) | Recruiting | University of Oxford | 750000 | 2026-08-01 | 2026-10-22 | |
| CARE Qualitative Study Cardiac Surgery | Recruiting | University Hospitals Bristol and Weston NHS Foundation Trust | 24 | 2026-05-27 | 2026-06-05 | |
| Is the Use of a Steam Mask an Effective Treatment for Paediatric Chalazion in Comparison to Traditional Warm Compresses? Steam device, Warm Compress - Chalazion | Not applicable | Recruiting | University of Sheffield | 28 | 2026-03-10 | 2026-07-23 |
| MND Together: Phase 1 Not applicable- observational study - MND (Motor Neurone DIsease) | Not yet recruiting | University of Sheffield | 287 | 2026-02-01 | 2026-02-06 | |
| Troponin in Acute Chest Pain to Risk Stratify and Guide EffecTive Use of Computed Tomography Coronary Angiography CT Coronary Angiography (CTCA) - Coronary Artery Disease | Not applicable | Active not recruiting | University of Edinburgh | 3170 | 2026-01-31 | 2026-04-21 |
| Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis EXERCISE TRAINING, Antiresorptive medication (routine clinical care) - Osteoporosis in Post-menopausal Women | Not applicable | Not yet recruiting | Loughborough University | 110 | 2026-01-01 | 2025-12-05 |
| The Effect of 5-hydroxytryptophan on ADHD Traits and Eye Movements 5-hydroxytryptophan (food supplement) 200mg, 5-hydroxytryptophan (food supplement) 300mg, Placebo - Attention Deficit and Hyperactivity Disorder (ADHD), Attention Deficit Hyperactivity Disorder in Adults | Not applicable | Recruiting | University of Sheffield | 150 | 2025-11-25 | 2026-08-20 |
| Closed Loop and Education for Hypoglycemia Awareness Restoration Omnipod 5 or Medtronic 780G, My HypoCOMPaSS Education, HARPdoc Education - Diabetes Mellitus, Type 1 | Not applicable | Recruiting | Milton S. Hershey Medical Center | 324 | 2025-10-03 | 2026-03-03 |
| Exercise to Boost Immunity in Advanced Cancer Exercise - Mesothelioma; Lung, Pancreatic Cancer | Not applicable | Not yet recruiting | Sheffield Teaching Hospitals NHS Foundation Trust | 30 | 2025-09-01 | 2024-12-03 |
| Effectiveness of CAT-GSH for Returning Patients Cognitive analytic therapy guided self-help (CAT-GSH), Cognitive behavioural therapy guided self-help (CBT-GSH) - Anxiety, Depression | Not applicable | Recruiting | University of Sheffield | 100 | 2025-07-30 | 2025-10-03 |
| StratCare Trial 2: Evaluating the Clinical and Cost-effectiveness of AI-driven Stratified Care for Depression StratCare - Depression | Not applicable | Recruiting | Rotherham Doncaster and South Humber NHS Foundation Trust | 1252 | 2025-06-27 | 2026-07-28 |
| Moving on After Breast Cancer Trial for Depressed Breast Cancer Survivors in Pakistan Non-specialist delivered Low intensity guided self-help (Khushi and Khatoon), Moving on After Breast Cancer (ABC) plus, Standardised pharmacological treatment (antidepressants) - Major Depressive Disorder (MDD), Breast Cancer Survivor | Not applicable | Recruiting | Pakistan Institute of Living and Learning | 26376 | 2025-06-13 | 2026-03-18 |
| TReating Unhelpful Suspicious Thoughts in Adolescents (TRUST): a School-based Case Series TRUST - Paranoia | Not applicable | Enrolling by invitation | University of Sheffield | 8 | 2025-05-02 | 2025-05-16 |
| Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders Unified Protocol - Common Mental Health Problems, Anxiety | Not applicable | Recruiting | Rotherham Doncaster and South Humber NHS Foundation Trust | 660 | 2025-04-30 | 2025-07-10 |
| Routine Outcome Monitoring and Feedback Informed Therapy in Italy (Feedback Informed Therapy) with Clinical Support Tools and ah hoc training, Feedback and ROM (basic) - Feedback, Psychological | Not applicable | Recruiting | University of Bergamo | 180 | 2025-03-25 | 2025-03-30 |
| Intergrated Service Delivery for Lung Health Conditions Intergrated lung health screening, AI-Enabled Cough Sound Screening for Tuberculosis, Post-TB Lung Disease evaluation - TB - Tuberculosis, PTLD | Active not recruiting | Centre for Infectious Disease Research in Zambia | 20300 | 2025-03-03 | 2026-09-11 |
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Depression (15) · Osteoporosis (9) · Anxiety Disorders (8) · Psychological Well-Being (7) · Pulmonary Disease, Chronic Obstructive (7) · Breast Neoplasms (6) · Dermatitis, Atopic (6) · Hypertension, Pulmonary (6) · Obesity (5) · Amyotrophic Lateral Sclerosis (4) · COVID-19 (4) · Motor Activity (4) · Pulmonary Arterial Hypertension (4) · Skin Diseases (4) · Tuberculosis (4)
Therapeutics (6) · Acceptance and Commitment Therapy (3) · Zoledronic Acid (3) · Amplified Fragment Length Polymorphism Analysis (2) · Clopidogrel (2) · Exercise (2) · Immunohistochemistry (2) · Mass Screening (2) · Microarray Analysis (2) · Mindfulness-Based Stress Reduction (2) · Observation (2) · Polymerase Chain Reaction (2) · ursodoxicoltaurine (2) · 5-Hydroxytryptophan (1) · ACE-011 (1)
United Kingdom (179) · Germany (10) · Netherlands (7) · France (6) · Italy (5) · Belgium (4) · Portugal (4) · Denmark (3) · Ireland (3) · Norway (3) · Zambia (3) · Australia (2) · Austria (2) · Cameroon (2) · Finland (2)
Amrit Sinha (2) · Angela Cox, PhD (2) · Chris McDermott, MBChB, FRCP, PhD (2) · Danielle E Matthews, PhD (2) · David Kiely, MD (2) · Georgina L Jones, D.Phil (2) · Jennifer S Walsh, MBChB PhD (2) · Robert E. Coleman, MD, FRCP (2) · Thomas Darton (2) · Timothy Chico (2) · A Wray (1) · Agata Debowska, PhD (1) · Agostino Brugnera, Assistant Professor (1) · Alastair Greystoke, MB ChB, MSc, PhD (1) · Albert Ong (1)
PMID 38979716, PMID 18794162, PMID 18829679, PMID 20234364, PMID 21394500, PMID 21885399, PMID 21969018, PMID 21995387, PMID 23515409, PMID 23838763, PMID 23868093, PMID 24885032, PMID 25035292, PMID 25389139, PMID 25400253, PMID 25495835, PMID 25525693, PMID 26295732, PMID 26515417, PMID 26555692, PMID 26590903, PMID 27974370, PMID 28087556, PMID 28289046, PMID 28405470, PMID 28472303, PMID 28656968, PMID 29269441, PMID 29458392, PMID 29463288, PMID 29628776, PMID 30002102, PMID 30166303, PMID 30311686, PMID 30687504, PMID 31047905, PMID 31434765, PMID 31526754, PMID 31619435, PMID 31981516, PMID 32131882, PMID 32201256, PMID 32328500, PMID 32375741, PMID 32445688, PMID 32456684, PMID 32634435, PMID 32682441, PMID 32702336, PMID 32747075
2018 (2), 2019 (1), U01DK135126 (1)