293 completed, 75 terminated, 68 recruiting, 63 unknown. 345 Phase 2, 149 Phase 1, 128 Phase 3, 18 Not applicable, 5 Phase 4.
Follow 5-FU: new trials by email Literature Review of 5-FU trials Research Report on 5-FU
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Not yet recruiting | Northwestern University | 125 | 2027-02-03 | 2026-08-06 |
| Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of Ependymoma Biospecimen Collection, Echocardiography Test, Fluorouracil - Childhood Posterior Fossa Ependymoma | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 70 | 2026-12-11 | 2026-09-30 |
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| A Trial of Pembrolizumab With Chemotherapy or Chemoradiotherapy in Participants From India With Different Types of Cancer (MK-3475-G44/KEYNOTE-G44) Pembrolizumab, Cisplatin, 5-Fluorouracil - Neoplasm Malignant, Gastric Neoplasms | Phase 4 | Not yet recruiting | Merck Sharp & Dohme LLC | 150 | 2026-11-06 | 2026-09-03 |
| A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) and Pembrolizumab (MK-3475A) in Participants With Bladder Cancer (MK-2870-055) Sac-TMT, Pembrolizumab and Berahyaluronidase alfa, Cisplatin - Bladder Cancer | Phase 3 | Not yet recruiting | Merck Sharp & Dohme LLC | 400 | 2026-10-20 | 2026-09-21 |
| Study of Petosemtamab Plus Chemotherapy Versus Cetuximab or Bevacizumab Plus Chemotherapy in RAS and BRAF Wild Type, Recurrent, Unresectable or Metastatic Colorectal Cancer (LiGeR-CRC2) Petosemtamab, Cetuximab, Bevacizumab - Colorectal Cancer | Phase 3 | Recruiting | Genmab | 600 | 2026-10-07 | 2026-10-09 |
| DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic Cancer Biospecimen Collection, Computed Tomography, Dynamic Contrast-Enhanced Magnetic Resonance Imaging - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2026-10-01 | 2026-10-05 |
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2026-10-01 | 2026-09-25 |
| Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer Tovecimig, Irinotecan, Leucovorin - Colorectal Cancer, Metastatic Colorectal Cancer | Phase 2 | Not yet recruiting | Washington University School of Medicine | 25 | 2026-08-31 | 2026-06-23 |
| Carbon Dioxide Laser-Assisted Delivery of Triamcinolone With or Without 5-Fluorouracil for Hypertrophic Burn Scars Fractional Ablative CO₂ Laser, Triamcinolone Acetonide, Fluorouracil (5-FU) - Burn, Hypertrophic Scars | Not applicable | Not yet recruiting | University of California, Davis | 65 | 2026-08-22 | 2026-08-24 |
| Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases Cancer Abemaciclib, Oxaliplatin, Calcium Folinate - Liver Metastases From Colorectal Cancer (mCRC) | Phase 2 | Enrolling by invitation | Fudan University | 16 | 2026-07-30 | 2026-07-22 |
| A Study of ASP2138 Together With Chemotherapy and Pembrolizumab in Adults With Gastric Cancer ASP2138, Pembrolizumab, Oxaliplatin - Gastric Adenocarcinoma, Gastroesophageal Junction (GEJ) Adenocarcinoma | Phase 3 | Recruiting | Astellas Pharma Global Development, Inc. | 570 | 2026-07-28 | 2026-10-22 |
| AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients With Borderline Resectable, Locally Advanced or Metastatic Cholangiocarcinoma or Pancreatic Cancer Biopsy Procedure, Cisplatin, Computed Tomography - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Locally Advanced Cholangiocarcinoma | Phase 1 | Recruiting | Jonsson Comprehensive Cancer Center | 46 | 2026-05-29 | 2026-08-20 |
| Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations Biospecimen Collection, Computed Tomography, Fluorouracil - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 94 | 2026-05-13 | 2026-05-22 |
| Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy Biospecimen Collection, Capecitabine, Diltiazem Hydrochloride - Malignant Digestive System Neoplasm | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 60 | 2026-04-30 | 2026-06-02 |
| A Phase II Study of AMT-676 Combination Therapies in Advanced Colorectal Cancer AMT-676, 5-FU, Leucovorin - Colorectal Cancer | Phase 2 | Recruiting | Multitude Therapeutics Inc. | 180 | 2026-04-29 | 2026-08-27 |
| 5-Fluorouracil Response and Optimization STudy (The FROST Trial) 5-Fluorouracil - Squamous Cell Carcinoma of Head and Neck, Metastatic Squamous Cell Carcinoma | Phase 2 | Recruiting | Washington University School of Medicine | 46 | 2026-04-21 | 2026-04-27 |
| A Study Evaluating the Safety and Efficacy of JS212 Combination Therapy in Patients With Advanced Esophageal Squamous Cell Carcinoma JS212, JS001, 5-FU - Advanced Esophageal Squamous Cell Carcinoma | Phase 2 | Recruiting | Shanghai Junshi Bioscience Co., Ltd. | 280 | 2026-04-13 | 2026-04-22 |
| A Study of BMS-986504 With Standard-of-Care Therapy for People With Solid Tumor Cancer BMS-986504, Ipilimumab, Nivolumab - Diffuse Pleural Mesothelioma, Gastroesophageal Carcinoma | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 60 | 2026-04-07 | 2026-09-16 |
| Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer FOLFOXIRI, CAPOX, FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) - Locally Advanced Rectal Carcinoma | Phase 3 | Not yet recruiting | J. W. A. Burger | 394 | 2026-03-03 | 2026-03-16 |
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Colorectal Neoplasms (135) · Rectal Neoplasms (84) · Pancreatic Neoplasms (65) · Stomach Neoplasms (63) · Colonic Neoplasms (60) · Esophageal Neoplasms (50) · Neoplasms (29) · Squamous Cell Carcinoma of Head and Neck (28) · Neoplasm Metastasis (27) · Breast Neoplasms (26) · Adenocarcinoma Of Esophagus (24) · Esophageal Squamous Cell Carcinoma (18) · Head and Neck Neoplasms (17) · Gastrointestinal Neoplasms (12) · Urinary Bladder Neoplasms (11)
National Cancer Institute (NCI) (60) · M.D. Anderson Cancer Center (34) · Sun Yat-sen University (16) · Merck Sharp & Dohme LLC (15) · SWOG Cancer Research Network (13) · City of Hope Medical Center (11) · ECOG-ACRIN Cancer Research Group (10) · Washington University School of Medicine (9) · AstraZeneca (8) · Fudan University (7) · Massachusetts General Hospital (7) · Mayo Clinic (7) · Roswell Park Cancer Institute (7) · University of Chicago (7) · Eli Lilly and Company (6)
United States (367) · China (86) · Germany (58) · Canada (45) · Spain (44) · South Korea (35) · Australia (34) · France (34) · Japan (34) · United Kingdom (34) · Italy (30) · Taiwan (28) · Belgium (23) · Puerto Rico (21) · Brazil (17)
Marwan Fakih (5) · Norman Wolmark, MD (5) · Jane Robertson (4) · Jian Xiao, MD (4) · Dimitris Mavrudis, MD (3) · Everett Vokes, MD (3) · Jaffer Ajani, MD (3) · John Souglakos, MD (3)
PMID 31268130, PMID 33356421, PMID 21997132, PMID 28006055, PMID 30679026, PMID 31378656, PMID 31811950, PMID 32816630, PMID 33792646, PMID 36306483, PMID 37037952, PMID 37699333, PMID 37957132, PMID 38315963, PMID 39863139, PMID 40117530, PMID 40207789, PMID 12448660, PMID 12518365, PMID 14759776, PMID 15496622, PMID 15625363, PMID 15774775, PMID 15800321, PMID 15930421, PMID 16098249, PMID 16479065, PMID 16515704, PMID 16532436, PMID 16568451, PMID 16832602, PMID 16877719, PMID 17470851, PMID 17470859, PMID 17853393, PMID 17960012, PMID 17960013, PMID 18650621, PMID 19203899, PMID 19525947, PMID 19738454, PMID 19897418, PMID 19930599, PMID 20037779, PMID 20233444, PMID 20670978, PMID 20728210, PMID 20797891, PMID 20803065, PMID 21205754
U10CA180820 (13), U10CA032102 (12), U10CA021115 (9), U10CA180868 (9), 2017 (8), U10CA180888 (8), 2014 (7), 2023 (6), 2015 (5), P30CA033572 (5), 2009 (4), 2016 (4), 2018 (4), P30CA036727 (4), U10CA012027 (4)