18 completed, 3 recruiting, 3 unknown, 2 active not recruiting. 6 Phase 2, 5 Phase 3, 4 Phase 1, 3 Phase 4, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 5, Recruiting 1 |
| Phase 3 | 5 | Completed 5 |
| Phase 1 | 4 | Completed 3, Recruiting 1 |
| Phase 4 | 3 | Unknown 2, Completed 1 |
| Early Phase 1 | 1 | Completed 1 |
| Not applicable | 1 | Recruiting 1 |
Follow X-linked Hypophosphatemia: new trials by email Literature Review of X-linked Hypophosphatemia trials Research Report on X-linked Hypophosphatemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phosphorus-31 Spectroscopy in Phosphate Diabetes intra-muscular ATP values in phosphate diabetes, intra-muscular phosphate values in phosphate diabetes - Phosphate Diabetes, X-linked Hypophosphatemia | Not applicable | Recruiting | Hospices Civils de Lyon | 65 | 2025-05-16 | 2026-07-23 |
| A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia KK8123 - X-linked Hypophosphatemia | Phase 1 / Phase 2 | Recruiting | Kyowa Kirin Co., Ltd. | 39 | 2024-10-09 | 2026-09-21 |
| A Study to Describe the Lived Experience of XLH for Adolescents at End of Skeletal Growth Burosumab - X-Linked Hypophosphatemia | Completed | Kyowa Kirin Pharmaceutical Development Ltd | 25 | 2021-11-24 | 2026-07-13 | |
| Anti-FGF23 (Burosumab) in Adult Patients With XLH Burosumab - X-linked Hypophosphatemia | Phase 3 | Completed | Wuerzburg University Hospital | 36 | 2021-01-07 | 2023-05-03 |
| Foot Disorders in X-linked Hypophosphatemia Foot X rays, Clinical examination + scores - X-linked Hypophosphatemia | Completed | Orthopedic Hospital Vienna Speising | 28 | 2020-07-01 | 2023-10-10 | |
| Characterising Pain, QoL, Body Composition, Arterial Stiffness, Muscles and Bones in Adult Persons With XLH and Healthy Controls X-linked Hypophosphatemia, Hereditary Hypophosphatemia | Completed | University of Aarhus | 92 | 2020-02-18 | 2023-11-29 | |
| Examining the Effect of Burosumab on Muscle Function Burosumab Injection [Crysvita] - X-linked Hypophosphatemia | Phase 4 | Completed | Yale University | 10 | 2019-11-13 | 2023-08-24 |
| Dental Implants in Patients With X-linked Hypophosphatemia Dental Implant placement - X-linked Hypophosphatemia | Unknown | Assistance Publique - Hôpitaux de Paris | 36 | 2019-09-27 | 2022-06-30 | |
| Calcitriol Monotherapy for X-Linked Hypophosphatemia Calcitriol - X-linked Hypophosphatemia, Hypophosphatemic Rickets | Early Phase 1 | Completed | Massachusetts General Hospital | 16 | 2019-03-28 | 2026-05-07 |
| Study of the Anti-FGF23 Antibody, Burosumab, in Adults With XLH Burosumab - X-linked Hypophosphatemia | Phase 3 | Completed | Kyowa Kirin Pharmaceutical Development Ltd | 35 | 2019-03-07 | 2022-05-20 |
| X-linked Hypophosphatemia and FGF21 Descriptive study - X-linked Hypophosphatemia | Completed | Hospices Civils de Lyon | 39 | 2019-01-11 | 2020-10-27 | |
| FGF23 and Angiotensin-(1-7) in Hypophosphatemia (GAP) Ang II and Ang-(1-7), FGF23 and klotho - Hypophosphatemia, X-linked Hypophosphatemia | Completed | Wake Forest University Health Sciences | 8 | 2018-12-06 | 2022-08-05 | |
| X-linked Hypophosphatemia Disease Monitoring Program No intervention - X-linked Hypophosphatemia, Hypophosphatemic Rickets | Active not recruiting | Ultragenyx Pharmaceutical Inc | 782 | 2018-07-16 | 2026-08-28 | |
| Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian Partners no intervention - X-Linked Hypophosphatemia | Active not recruiting | Kyowa Kirin Co., Ltd. | 226 | 2018-05-01 | 2025-09-05 | |
| Burosumab in Children and Adolescents With X-linked Hypophosphatemia Burosumab Injection - Rare Diseases, X-linked Hypophosphatemia | Phase 4 | Unknown | Bicetre Hospital | 57 | 2018-03-18 | 2020-06-05 |
| Registry for Patients With X-Linked Hypophosphatemia X-Linked Hypophosphatemia | Recruiting | Kyowa Kirin Pharmaceutical Development Ltd | 1489 | 2017-09-12 | 2026-07-09 | |
| Using Different Doses of Active Vitamin D Combined With Neutral Phosphate in Children With X-linked Hypophosphatemia Calcitriol - X-linked Hypophosphatemia | Phase 4 | Unknown | Peking Union Medical College Hospital | 100 | 2017-01-01 | 2019-01-30 |
| Efficacy and Safety of Burosumab Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients With XLH burosumab, Oral Phosphate Supplement, active vitamin D - X-Linked Hypophosphatemia | Phase 3 | Completed | Kyowa Kirin, Inc. | 61 | 2016-09-08 | 2024-08-29 |
| Study of the Safety, Pharmacodynamics (PD) and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH) Burosumab - X-Linked Hypophosphatemia | Phase 2 | Completed | Kyowa Kirin, Inc. | 13 | 2016-05-05 | 2024-05-06 |
| Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH) burosumab - X-linked Hypophosphatemia | Phase 3 | Completed | Kyowa Kirin, Inc. | 14 | 2015-12-23 | 2024-06-18 |
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Familial Hypophosphatemic Rickets (27) · Hypophosphatemia (5) · Rickets, Hypophosphatemic (3) · Bone Diseases (2) · Rare Diseases (2) · Hyperparathyroidism (1) · Hypertrophy, Left Ventricular (1) · Hypophosphatemia, Familial (1) · Kidney Diseases (1) · Metabolic Diseases (1) · Musculoskeletal Diseases (1) · Oncogenic osteomalacia (1) · Rickets (1)
Avitaminosis (27) · Bone Diseases, Metabolic (27) · Calcium Metabolism Disorders (27) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (27) · Deficiency Diseases (27) · Female Urogenital Diseases (27) · Female Urogenital Diseases and Pregnancy Complications (27) · Genetic Diseases, Inborn (27) · Male Urogenital Diseases (27) · Malnutrition (27) · Metabolism, Inborn Errors (27) · Metal Metabolism, Inborn Errors (27) · Nutrition Disorders (27) · Nutritional and Metabolic Diseases (27) · Phosphorus Metabolism Disorders (27)
burosumab (15) · Calcitriol (2) · 1,25-dihydroxyvitamin D (1) · Physical Examination (1)
Kyowa Kirin Co., Ltd. (6) · Kyowa Kirin, Inc. (6) · Kyowa Kirin Pharmaceutical Development Ltd (3) · Hospices Civils de Lyon (2) · Assistance Publique - Hôpitaux de Paris (1) · Bicetre Hospital (1) · Massachusetts General Hospital (1) · Orthopedic Hospital Vienna Speising (1) · Peking Union Medical College Hospital (1) · Ultragenyx Pharmaceutical Inc (1) · University of Aarhus (1) · Wake Forest University Health Sciences (1) · Wuerzburg University Hospital (1) · Yale University (1)
United States (14) · France (11) · Canada (6) · United Kingdom (6) · Germany (4) · Japan (4) · Denmark (3) · Ireland (3) · Italy (3) · Netherlands (3) · South Korea (3) · Spain (3) · Sweden (2) · Argentina (1) · Australia (1)
Amy Zhang, PhD (2) · Andrew M South, MD MS (1) · Eva Liu, MD (1) · Gabriel Mindler, Dr (1) · Karl L Insogna, M.D. (1) · Lars Rejnmark (1) · Lothar Seefried, MD (1) · Martin Biosse Duplan, DDS, PhD (1) · Peter Kamenicky (1) · Thomas O. Carpenter, M.D. (1)
PMID 39151033, PMID 32721016, PMID 40962182, PMID 25919461, PMID 36854566, PMID 24569459, PMID 26073451, PMID 29791829, PMID 29947083, PMID 30638856, PMID 31104833, PMID 31165191, PMID 32601114, PMID 33484279, PMID 34548383, PMID 34636899, PMID 35533340, PMID 35775373, PMID 35927518, PMID 36072994, PMID 36082134, PMID 37084401, PMID 37752558, PMID 40074938, PMID 41030383, PMID 41634723, PMID 41860923, PMID 41911946, PMID 42038817, PMID 42756680
2014 (1)