9 unknown. 9 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Unknown 9 |
| Phase 1 | 3 | Unknown 3 |
| Phase 3 | 2 | Unknown 2 |
Follow Vision Disorders: new trials by email Literature Review of Vision Disorders trials Research Report on Vision Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tirzepatide Monotherapy in Patients With Wolfram Syndrome Type 1 Tirzepatide - Wolfram Syndrome | Phase 2 | Unknown | Ospedale San Raffaele | 10 | 2024-01-01 | 2024-02-22 |
| Efficacy Study of Daily Administration of VPA in Patients Affected by Wolfram Syndrome Depakine - Wolfram Syndrome | Phase 2 | Unknown | Centre d'Etude des Cellules Souches | 23 | 2021-11-26 | 2023-11-28 |
| An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene. sepofarsen - Leber Congenital Amaurosis 10, Blindness | Phase 2 / Phase 3 | Unknown | ProQR Therapeutics | 15 | 2021-03-23 | 2022-03-25 |
| Single Ascending Dose Study in Participants With LCA10 EDIT-101 - Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies | Phase 1 / Phase 2 | Unknown | Editas Medicine, Inc. | 34 | 2019-09-26 | 2022-12-05 |
| Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGA3 Achromatopsia (A Clarity Clinical Trial) AGTC-402 - Achromatopsia | Phase 1 / Phase 2 | Unknown | Beacon Therapeutics | 24 | 2017-08-03 | 2022-07-22 |
| Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGB3 Achromatopsia (A Clarity Clinical Trial) rAAV2tYF-PR1.7-hCNGB3 - Achromatopsia | Phase 1 / Phase 2 | Unknown | Beacon Therapeutics | 32 | 2016-04-11 | 2022-07-22 |
| Bupivacaine Injection of Eye Muscles to Treat Strabismus Bupivacaine - Strabismus, Esotropia | Phase 2 / Phase 3 | Unknown | Smith-Kettlewell Eye Research Institute | 120 | 2012-04-01 | 2019-09-23 |
| Sub-tenon Triamcinolone Acetonide in Age-Related Macular Degeneration as Adjunct to Ranibizumab Ranibizumab, Triamcinolone Acetonide - Wet Macular Degeneration | Phase 2 | Unknown | University Health Network, Toronto | 30 | 2011-01-01 | 2011-02-09 |
| Polycaprolactone / Tricalcium Phosphate (PCL/TCP) v Titanium Orbital Implant : Randomised Trial Polycaprolactone / Tri-Calcium Phosphate, Titanium Mesh - Fractures, Enophthalmos | Phase 2 | Unknown | National University Hospital, Singapore | 80 | 2010-04-01 | 2014-04-28 |
Color Vision Defects (2) · Diplopia (2) · Eye Abnormalities (2) · Eye Diseases (2) · Leber Congenital Amaurosis (2) · Leber Congenital Amaurosis 10 (2) · Meckel Syndrome, Type 4 (2) · Neurologic Manifestations (2) · Retinal Degeneration (2) · Retinal Diseases (2) · Sensation Disorders (2) · Wolfram Syndrome (2) · Blepharoptosis (1) · Blindness (1)
Nervous System Diseases (8) · Eye Diseases (7) · Neurologic Manifestations (7) · Pathological Conditions, Signs and Symptoms (7) · Sensation Disorders (7) · Signs and Symptoms (6) · Eye Diseases, Hereditary (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Congenital Abnormalities (3) · Cranial Nerve Diseases (3) · Endocrine System Diseases (3) · Abnormalities, Multiple (2) · Blindness (2) · Cone Dystrophy (2)
Bupivacaine (1) · Ranibizumab (1) · Tirzepatide (1) · Triamcinolone Acetonide (1) · Valproic Acid (1)
Beacon Therapeutics (2) · Centre d'Etude des Cellules Souches (1) · Editas Medicine, Inc. (1) · National University Hospital, Singapore (1) · Ospedale San Raffaele (1) · ProQR Therapeutics (1) · Smith-Kettlewell Eye Research Institute (1) · University Health Network, Toronto (1)
United States (4) · Canada (2) · Italy (2) · Belgium (1) · Brazil (1) · France (1) · Germany (1) · Israel (1) · Netherlands (1) · Singapore (1) · Spain (1) · United Kingdom (1)
David Jacobs, MD, MBA (2) · Alan B Scott, MD (1) · Joel M Miller, PhD (1) · Lorenzo Piemonti, MD (1) · Thiam Chye Lim, MD (1) · Wai-Ching Lam, MD, FRCSC (1)
PMID 20126486, PMID 30194931, PMID 33497524, PMID 34629400, PMID 38709228
R24EY022023 (1)