5 recruiting, 2 active not recruiting, 2 not yet recruiting, 1 completed. 6 Phase 2, 2 Not applicable, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Recruiting 4, Active not recruiting 1, Unknown 1 |
| Not applicable | 2 | Active not recruiting 1, Not yet recruiting 1 |
| Phase 1 | 2 | Active not recruiting 1, Completed 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Vascular Anomalies: new trials by email Literature Review of Vascular Anomalies trials Research Report on Vascular Anomalies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Clinical Practice and Real-world Care of Patients Treated With mTOR, PI3K, and MEK Inhibitors for Extracranial Vascular Anomalies Vascular Anomalies | Not yet recruiting | Novartis Pharmaceuticals | 200 | 2026-09-30 | 2026-09-01 | |
| 24VA022; VATCH Alpelisib for TIE2/PIK3CA Pathway VAs alpelisib (BYL719) - Vascular Anomalies, Vascular Anomaly | Phase 2 | Recruiting | Children's Hospital of Philadelphia | 61 | 2025-08-27 | 2026-10-19 |
| 24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs Trametinib - Ras/MAPK Pathway Vascular Anomalies, Vascular Anomalies | Phase 2 | Recruiting | Children's Hospital of Philadelphia | 45 | 2025-08-27 | 2026-10-19 |
| Trametinib Treatment for Complicated Vascular Anomalies Trametinib tablet - Vascular Anomalies | Phase 1 / Phase 2 | Active not recruiting | West China Hospital | 20 | 2025-07-07 | 2025-07-22 |
| A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study) RLY-2608, Placebo - PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations | Phase 2 | Recruiting | Relay Therapeutics, Inc. | 277 | 2025-06-13 | 2026-08-25 |
| Radiofrequency Ablation of Vascular Anomalies Radiofrequency ablation alone - Vascular Anomalies | Not applicable | Not yet recruiting | Baylor College of Medicine | 15 | 2025-03-01 | 2025-01-31 |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| Institutional Registry of Rare Diseases Rare Diseases, Amyloidosis | Recruiting | Hospital Italiano de Buenos Aires | 380 | 2024-07-01 | 2026-01-14 | |
| Safety and Efficacy Of Amber Peripheral Liquid Embolic System amber SEL-P Peripheral Liquid Embolic System - Vascular Anomalies, Hemorrhage | Not applicable | Active not recruiting | LVD Biotech S.L | 70 | 2024-06-12 | 2024-06-17 |
| Efficacy and Safety of Rapamycin to Complex Vascular Anomalies in Pediatric Patients Treatment with oral rapmycin - Vascular Anomalies | Phase 2 / Phase 3 | Unknown | Zhujiang Hospital | 30 | 2017-12-01 | 2021-11-10 |
| Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Marimastat - Vascular Anomalies | Phase 1 | Completed | Boston Children's Hospital | 9 | 2000-10-01 | 2008-01-09 |
Vascular Malformations (11) · Lymphatic Abnormalities (4) · Arteriovenous Malformations (2) · Adrenal Hyperplasia, Congenital (1) · Amyloidosis (1) · Aneurysm (1) · Aneurysm, False (1) · Angioedemas, Hereditary (1) · Cardiomyopathy, Hypertrophic (1) · Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi (1) · Cushing Syndrome (1) · Demyelinating Diseases (1) · Eosinophilic Esophagitis (1) · Gaucher Disease (1) · Hemorrhage (1)
Cardiovascular Abnormalities (11) · Cardiovascular Diseases (11) · Congenital Abnormalities (11) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Hemic and Lymphatic Diseases (5) · Lymphatic Diseases (5) · Vascular Diseases (5) · Angiomatosis (2) · Genetic Diseases, Inborn (2) · Heredodegenerative Disorders, Nervous System (2) · Neoplasms (2) · Neoplasms by Histologic Type (2) · Nervous System Diseases (2) · Neurodegenerative Diseases (2) · Pathologic Processes (2)
Alpelisib (2) · trametinib (2) · Radiofrequency Ablation (1) · Therapeutics (1) · marimastat (1) · mirdametinib (1)
Children's Hospital of Philadelphia (2) · Baylor College of Medicine (1) · Boston Children's Hospital (1) · Hospital Italiano de Buenos Aires (1) · LVD Biotech S.L (1) · Murdoch Childrens Research Institute (1) · Novartis Pharmaceuticals (1) · Relay Therapeutics, Inc. (1) · West China Hospital (1) · Zhujiang Hospital (1)
United States (4) · Australia (2) · China (2) · Spain (2) · Argentina (1) · Belgium (1) · France (1) · Germany (1) · Ireland (1) · Italy (1) · United Kingdom (1)
Adrian Gadano, MD (1) · Eduardo Jorge Premoli, MD (1) · Hernan Garcia Rivello, MD (1) · Javier Pollan, MD (1) · Julio Busaniche, MD (1) · Luis Mazzuoccolo, MD (1) · Lydia Pathmanathan, MBBS, FRACP. (1) · Marcelo Risk, PhD (1) · Marcelo Rugiero, MD (1) · Marcelo Serra, PhD (1) · Maria Lourdes Posadas Martinez, PhD (1)
PMID 23796341, PMID 24252784, PMID 30542204, PMID 32894644, PMID 37264205, PMID 40102890