5 recruiting, 4 completed, 2 terminated, 1 not yet recruiting. 2 Phase 1, 2 Phase 2, 2 Phase 3, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Recruiting 1, Terminated 1 |
| Phase 2 | 2 | Recruiting 1, Terminated 1 |
| Phase 3 | 2 | Not yet recruiting 1, Recruiting 1 |
| Not applicable | 1 | Completed 1 |
Follow Usher Syndrome: new trials by email Literature Review of Usher Syndrome trials Research Report on Usher Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome N-acetylcysteine amide, Placebo - Retinitis Pigmentosa (RP), Usher Syndrome | Phase 3 | Not yet recruiting | Nacuity Pharmaceuticals, Inc. | 80 | 2026-12-01 | 2026-07-01 |
| A 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome Placebo, NPI-001 - Retinitis Pigmentosa (RP), Usher Syndrome | Phase 3 | Recruiting | Nacuity Pharmaceuticals, Inc. | 80 | 2026-10-01 | 2026-10-13 |
| Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance Transcorneal Electrical Stimulation using the OkuStim System - Retinitis Pigmentosa (RP), Usher Syndrome | Recruiting | Okuvision GmbH | 30 | 2026-04-20 | 2026-05-01 | |
| Natural History of Photoreceptor Degeneration in USH1B: Clinical Parameters and Validation of Functional Vision Tests in MYO7A Vision tests, Retinal imaging, Questionnaires - Usher Syndrome | Recruiting | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | 60 | 2025-10-13 | 2026-02-10 | |
| A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO) OpCT-001 - Primary Photoreceptor Disease, Retinitis Pigmentosa (RP) | Phase 1 / Phase 2 | Recruiting | BlueRock Therapeutics | 54 | 2025-03-10 | 2026-10-15 |
| Auditory Neural Function in Implanted Patients With Usher Syndrome Experimental manipulation of stimulation parameters - Usher Syndrome, Cochlear Implantation | Not applicable | Completed | Ohio State University | 29 | 2021-10-01 | 2025-07-29 |
| Clinical and Genetic Testing of Patients With Usher Syndrome Usher Syndrome, Congenital Deafness | Completed | Sensor Technology for Deafblind | 28 | 2017-05-17 | 2019-04-03 | |
| Inherited Retinal Degenerative Disease Registry Eye Diseases Hereditary, Retinal Disease | Recruiting | Foundation Fighting Blindness | 20000 | 2014-06-01 | 2026-05-19 | |
| Clinical and Genetic Examination of Usher Syndrome Patients' Cohort in Europe Usher Syndrome | Unknown | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | 100 | 2013-09-01 | 2015-02-04 | |
| Study of SAR421869 in Participants With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B SAR421869 - Usher Syndrome, Retinitis Pigmentosa | Phase 1 / Phase 2 | Terminated | Sanofi | 9 | 2012-03-26 | 2022-04-28 |
| Natural History and Genetic Studies of Usher Syndrome Retinitis Pigmentosa Syndromic, Congenital Deafness | Completed | National Eye Institute (NEI) | 249 | 2005-03-21 | 2019-12-12 | |
| A Genetic Analysis of Usher Syndrome in Ashkenazi Jews Audiogram, Electroretinogram - Usher Syndrome, Retinitis Pigmentosa | Completed | National Center for Research Resources (NCRR) | 2001-03-01 | 2005-06-24 | ||
| Study of Dietary N-3 Fatty Acids in Patients With Retinitis Pigmentosa and Usher Syndrome Usher Syndrome, Retinitis Pigmentosa | Terminated | National Center for Research Resources (NCRR) | 100 | 1999-10-01 | 2005-06-24 |
Usher Syndromes (13) · Retinitis Pigmentosa (11) · Cone-Rod Dystrophies (3) · Deafness (2) · Retinal Degeneration (2) · Retinal Diseases (2) · Abetalipoproteinemia (1) · Achromatopsia 3 (1) · Bardet-Biedl Syndrome (1) · Charcot-Marie-Tooth Disease (1) · Choroideremia (1) · Color Vision Defects (1) · Cone Dystrophy (1) · Enhanced S-Cone Syndrome (1) · Eye Diseases (1)
Abnormalities, Multiple (13) · Blindness (13) · Congenital Abnormalities (13) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (13) · Deaf-Blind Disorders (13) · Ear Diseases (13) · Hearing Disorders (13) · Hearing Loss (13) · Hearing Loss, Sensorineural (13) · Nervous System Diseases (13) · Neurologic Manifestations (13) · Otorhinolaryngologic Diseases (13) · Pathological Conditions, Signs and Symptoms (13) · Sensation Disorders (13) · Signs and Symptoms (13)
Hearing (1) · N-Acetylcysteinamide (1) · Vision Tests (1)
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (2) · Nacuity Pharmaceuticals, Inc. (2) · National Center for Research Resources (NCRR) (2) · BlueRock Therapeutics (1) · Foundation Fighting Blindness (1) · National Eye Institute (NEI) (1) · Ohio State University (1) · Okuvision GmbH (1) · Sanofi (1) · Sensor Technology for Deafblind (1)
United States (8) · France (3) · Germany (2) · Netherlands (1) · Portugal (1) · Russia (1)
Isabelle Audo, Pr (1) · Jose-Alain Sahel, MD, PhD (1) · Richard Weleber, MD (1) · Shuman He, MD, PhD (1) · Todd Durham, PhD (1) · Vladimir N Trubilin, MD, PhD, Prof (1) · Wadih Zein, M.D. (1) · William Connor (1)
PMID 24705452, PMID 30358468, PMID 32573764
R21DC019458 (1)