99 completed, 15 terminated, 8 unknown, 7 withdrawn. 72 Phase 1, 23 Phase 2, 16 Not applicable, 9 Phase 3.
Follow Unspecified Childhood Solid Tumor, Protocol Specific: new trials by email Literature Review of Unspecified Childhood Solid Tumor, Protocol Specific trials Research Report on Unspecified Childhood Solid Tumor, Protocol Specific
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors RRx-001, Temozolomide, Irinotecan - Brain Tumor, Recurrent, Brain Tumor, Pediatric | Phase 1 | Terminated | EpicentRx, Inc. | 2 | 2023-01-26 | 2024-10-31 |
| MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Morphotek | 27 | 2013-11-01 | 2016-01-08 |
| Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer filgrastim - Childhood Choroid Plexus Tumor, Childhood Medulloblastoma | Phase 3 | Terminated | Barbara Ann Karmanos Cancer Institute | 23 | 2013-08-01 | 2020-10-29 |
| Sirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery sirolimus, pharmacological study, laboratory biomarker analysis - Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific | Phase 1 | Completed | University of Chicago | 56 | 2012-06-13 | 2019-04-22 |
| Positron Emission Tomography/Magnetic Resonance Imaging in Patients magnetic resonance imaging with positron emission tomography scanning - Colon Cancer, Head and Neck Cancer | Not applicable | Terminated | Case Comprehensive Cancer Center | 98 | 2012-02-01 | 2020-02-24 |
| Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Real Acupressure Band, Placebo Acupressure Band - Central Nervous System Tumor, Pediatric, Chemotherapy-induced Nausea and Vomiting | Not applicable | Completed | University of South Florida | 187 | 2011-05-01 | 2021-08-18 |
| Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma imetelstat sodium, laboratory biomarker analysis, pharmacological study - Brain and Central Nervous System Tumors, Lymphoma | Phase 1 | Completed | Children's Oncology Group | 34 | 2011-05-01 | 2014-01-30 |
| Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant supersaturated calcium phosphate rinse, placebo, questionnaire administration - Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 226 | 2011-03-01 | 2019-09-17 |
| Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases intensity-modulated radiation therapy - Adult Rhabdomyosarcoma, Lung Metastases | Not applicable | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 20 | 2011-02-01 | 2025-02-10 |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Viral Therapy in Treating Young Patients With Relapsed or Refractory Solid Tumors wild-type reovirus, cyclophosphamide, laboratory biomarker analysis - Unspecified Childhood Solid Tumor, Protocol Specific | Phase 1 | Completed | National Cancer Institute (NCI) | 26 | 2010-12-01 | 2014-05-13 |
| INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease ruxolitinib phosphate, laboratory biomarker analysis, pharmacological study - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 | Completed | Children's Oncology Group | 49 | 2010-09-01 | 2014-10-23 |
| Temsirolimus, Irinotecan Hydrochloride, and Temozolomide in Treating Younger Patients With Relapsed or Refractory Solid Tumors temsirolimus, temozolomide, irinotecan hydrochloride - Unspecified Childhood Solid Tumor, Protocol Specific | Phase 1 | Completed | National Cancer Institute (NCI) | 72 | 2010-06-01 | 2014-04-10 |
| Quality of Life and Survivorship Care in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) HIPEC Orientation, Consultation with Survivorship Navigator, Questionnaires - Advanced Malignant Mesothelioma, Carcinoma of the Appendix | Not applicable | Completed | Wake Forest University Health Sciences | 10 | 2010-05-01 | 2018-07-03 |
| Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer massage therapy, questionnaire administration, quality-of-life assessment - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Not applicable | Completed | Wake Forest University Health Sciences | 80 | 2010-04-01 | 2018-07-02 |
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Temsirolimus and Valproic Acid in Treating Young Patients With Relapsed Neuroblastoma, Bone Sarcoma, or Soft Tissue Sarcoma Temsirolimus, Valproic Acid - Brain and Central Nervous System Tumors, Neuroblastoma | Phase 1 | Terminated | UNC Lineberger Comprehensive Cancer Center | 7 | 2009-11-01 | 2016-12-23 |
| Cyproheptadine Hydrochloride and Nutritional Supplementation in Treating Young Patients With Weight Loss With Cancer Ensure, PediaSure, cyproheptadine hydrochloride - Leukemia, Lymphoma | Phase 2 | Terminated | University of South Florida | 9 | 2009-09-01 | 2014-04-02 |
| AT9283 in Children and Adolescents With Relapsed and Refractory Solid Tumors multikinase inhibitor AT9283, enzyme-linked immunosorbent assay, immunohistochemistry staining method - Unspecified Childhood Solid Tumor, Protocol Specific | Phase 1 | Completed | Cancer Research UK | 33 | 2009-09-01 | 2019-11-29 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
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Burkitt Lymphoma (39) · Dendritic Cell Sarcoma, Interdigitating (39) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (37) · Recurrence (34) · Central Nervous System Neoplasms (27) · Lymphoma (27) · Medulloblastoma (27) · Astrocytoma (25) · Familial ependymoma (25) · Optic Nerve Glioma (25) · Lymphoma, Large B-Cell, Diffuse (24) · Neuroblastoma (24) · Leukemia (23) · Choroid Plexus Neoplasms (21) · Sarcoma (19)
Neoplasms (71) · Neoplasms by Histologic Type (71) · Neoplasms by Site (58) · Hemic and Lymphatic Diseases (55) · Pathological Conditions, Signs and Symptoms (52) · Immune System Diseases (50) · Immunoproliferative Disorders (49) · Lymphatic Diseases (49) · Lymphoproliferative Disorders (47) · Hematologic Diseases (45) · Pathologic Processes (45) · Neoplasms, Germ Cell and Embryonal (44) · Neoplasms, Glandular and Epithelial (44) · Neoplasms, Nerve Tissue (44) · Neuroectodermal Tumors (44)
Cyclophosphamide (14) · Irinotecan (12) · Filgrastim (11) · Busulfan (8) · Carboplatin (8) · Melphalan (8) · Etoposide (6) · Thiotepa (6) · Granulocyte Colony-Stimulating Factor (5) · Peripheral Blood Stem Cell Transplantation (5) · Radiotherapy (5) · Temozolomide (5) · Antilymphocyte Serum (4) · Oxaliplatin (4) · Topotecan (4)
National Cancer Institute (NCI) (38) · Children's Oncology Group (22) · Wake Forest University Health Sciences (6) · Children's Cancer and Leukaemia Group (5) · Roswell Park Cancer Institute (5) · University of South Florida (5) · National Institutes of Health Clinical Center (CC) (4) · Memorial Sloan Kettering Cancer Center (3) · Milton S. Hershey Medical Center (3) · Case Comprehensive Cancer Center (2) · City of Hope Medical Center (2) · Fred Hutchinson Cancer Center (2) · M.D. Anderson Cancer Center (2) · St. Jude Children's Research Hospital (2) · University of Medicine and Dentistry of New Jersey (2)
United States (118) · Canada (32) · Australia (14) · Switzerland (9) · United Kingdom (7) · Puerto Rico (6) · Ireland (5) · Netherlands (2) · New Zealand (2) · Belgium (1) · Czechia (1) · Finland (1) · France (1) · Germany (1) · Greece (1)
Maryam Fouladi (4) · Elizabeth Fox, MD (3) · Gareth Veal (3) · Kenneth G. Lucas, MD (3) · Barbara Jean Bambach, MD (2) · Brigitte C. Widemann, MD (2) · Ira Dunkel, MD (2) · Lisa McGregor (2) · Najat Daw (2) · Philip L. McCarthy, MD (2) · Richard Aplenc (2) · Susan Blaney (2) · Susan M. Blaney, MD (2) · Thomas J. Walsh, MD (2) · Thomas Williams McLean, MD (2)
PMID 15494606, PMID 15701855, PMID 15806544, PMID 16086046, PMID 16234526, PMID 16317728, PMID 16551859, PMID 16849757, PMID 16914576, PMID 17442992, PMID 17538173, PMID 17610262, PMID 18281544, PMID 18698002, PMID 18989154, PMID 19075272, PMID 19134445, PMID 19430790, PMID 20044751, PMID 20049936, PMID 20460632, PMID 20847174, PMID 21115653, PMID 21149673, PMID 21242495, PMID 23393050, PMID 23857966, PMID 29292843, PMID 30167756, PMID 32623479, PMID 33852135
U01CA097452 (24), U10CA081920 (5), P30CA072720 (3), U10CA098543 (3), P30CA021765 (2), U01CA062461 (2), U10CA045809 (2), P01CA018029 (1), P30CA006516 (1), P30CA006973 (1), P30CA008748 (1), P30CA012197 (1), P30CA015704 (1), P30CA016056 (1), P30CA016086 (1)