3 completed, 2 active not recruiting. 5 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 3, Active not recruiting 2 |
| Phase 2 | 5 | Completed 3, Active not recruiting 2 |
Follow Tuberous Sclerosis Complex: new trials by email Literature Review of Tuberous Sclerosis Complex trials Research Report on Tuberous Sclerosis Complex
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II Radiprodil - Tuberous Sclerosis Complex, Focal Cortical Dysplasia | Phase 1 / Phase 2 | Active not recruiting | GRIN Therapeutics, Inc. | 30 | 2024-07-10 | 2026-04-01 |
| Feasibility of [11C]Acetate-PET in LAM and TSC [11C]acetate - Lymphangioleiomyomatosis, Tuberous Sclerosis Complex | Phase 1 / Phase 2 | Active not recruiting | Brigham and Women's Hospital | 7 | 2021-08-30 | 2026-01-21 |
| Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC Infants TAVT-18 (sirolimus) - Tuberous Sclerosis Complex, Epilepsy | Phase 1 / Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 5 | 2020-09-08 | 2024-05-16 |
| Safety of Simvastatin in LAM and TSC Simvastatin, Sirolimus Oral Product, Everolimus Oral Product - Lymphangioleiomyomatosis, Tuberous Sclerosis Complex | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 10 | 2014-03-01 | 2020-08-25 |
| Everolimus (RAD001) Therapy for Epilepsy in Patients With Tuberous Sclerosis Complex (TSC) Everolimus - Epilepsy, Tuberous Sclerosis Complex | Phase 1 / Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 20 | 2010-01-01 | 2017-03-13 |
Tuberous Sclerosis (5) · Epilepsy (2) · Lymphangioleiomyomatosis (2) · Focal Cortical Dysplasia (1) · Hereditary Sensory and Autonomic Neuropathies (1)
Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Genetic Diseases, Inborn (5) · Hamartoma (5) · Heredodegenerative Disorders, Nervous System (5) · Malformations of Cortical Development (5) · Malformations of Cortical Development, Group I (5) · Neoplasms (5) · Neoplasms, Multiple Primary (5) · Neoplastic Syndromes, Hereditary (5) · Nervous System Diseases (5) · Nervous System Malformations (5) · Neurocutaneous Syndromes (5) · Neurodegenerative Diseases (5) · Brain Diseases (2)
Everolimus (2) · Sirolimus (2) · Simvastatin (1) · carbon-11 acetate (1) · radiprodil (1)
Children's Hospital Medical Center, Cincinnati (2) · Brigham and Women's Hospital (1) · GRIN Therapeutics, Inc. (1) · University of Pennsylvania (1)
United States (4) · Australia (1) · Belgium (1) · Canada (1) · Italy (1) · Netherlands (1) · Poland (1) · Spain (1) · United Kingdom (1)
Carmen P Priolo, MD PhD (1) · Darcy Krueger, M.D. Ph.D (1) · Darcy Krueger, MD, PhD (1) · Frank McCormack, MD (1) · Maryl Kreider, MD, MSCE (1) · Vera P Krymskaya, PhD, MBA (1)
PMID 21482669, PMID 23798472, PMID 39331837
2023 (1)