5 completed, 3 active not recruiting, 3 terminated, 2 recruiting. 8 Phase 2, 7 Phase 1, 1 Early Phase 1, 1 Phase 3.
Follow Therapy-Related Myelodysplastic Syndrome: new trials by email Literature Review of Therapy-Related Myelodysplastic Syndrome trials Research Report on Therapy-Related Myelodysplastic Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Venetoclax Basket Trial for High Risk Hematologic Malignancies Venetoclax, Azacitidine, Cytarabine - Myelodysplastic Syndromes, de Novo, Myelodysplastic Syndromes, Secondary | Phase 1 | Recruiting | Andrew E. Place, MD | 30 | 2023-03-29 | 2026-03-12 |
| Venetoclax and Azacitidine for Treatment of Therapy Related or Secondary Myelodysplastic Syndrome Azacitidine, Quality-of-Life Assessment, Questionnaire Administration - Secondary Myelodysplastic Syndrome, Therapy-Related Myelodysplastic Syndrome | Phase 2 | Active not recruiting | Uma Borate | 33 | 2022-06-23 | 2026-05-14 |
| Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies Orca-T, Standard-of-Care - Acute Myeloid Leukemia, Acute Lymphoid Leukemia | Phase 3 | Active not recruiting | Orca Biosystems, Inc. | 187 | 2022-06-21 | 2026-03-04 |
| Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients With Hematologic Malignancies Allogeneic Hematopoietic Stem Cell Transplantation, Irradiated Allogeneic Cells - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia in Remission | Early Phase 1 | Terminated | Rutgers, The State University of New Jersey | 2 | 2020-10-26 | 2023-06-26 |
| Venetoclax and Azacitidine for the Treatment of Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia Azacitidine, Venetoclax - Recurrent Chronic Myelomonocytic Leukemia, Recurrent Myelodysplastic Syndrome | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 34 | 2020-09-04 | 2026-06-05 |
| Venetoclax and Azacitidine for the Treatment of High-Risk Recurrent or Refractory Myelodysplastic Syndrome Azacitidine, Venetoclax - Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 51 | 2019-10-01 | 2026-02-12 |
| Ibrutinib and Lenalidomide in Treating Patients With Myelodysplastic Syndrome Ibrutinib, Lenalidomide - Myelodysplastic Syndrome, Previously Treated Myelodysplastic Syndrome | Phase 1 | Completed | University of California, Davis | 4 | 2017-12-01 | 2026-03-10 |
| Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma Anti-Thymocyte Globulin, Busulfan, Clofarabine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 6 | 2017-10-13 | 2023-10-11 |
| Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Cyclophosphamide, Filgrastim, Fludarabine Phosphate - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Completed | M.D. Anderson Cancer Center | 11 | 2017-01-18 | 2023-02-16 |
| Personalized NK Cell Therapy in CBT Allogeneic Natural Killer Cell Line NK-92, Anti-Thymocyte Globulin, Busulfan - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 100 | 2016-05-19 | 2026-07-30 |
| Vosaroxin and Infusional Cytarabine in Treating Patients With Untreated Acute Myeloid Leukemia Cytarabine, Vosaroxin - Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 2 | Completed | Vanderbilt-Ingram Cancer Center | 42 | 2016-03-01 | 2025-04-15 |
| Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia, Acute Leukemia in Remission, or Chronic Myelomonocytic Leukemia clofarabine, melphalan, allogeneic hematopoietic stem cell transplantation - Adult Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 2 | Active not recruiting | City of Hope Medical Center | 72 | 2014-02-10 | 2026-08-27 |
| Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies Aldesleukin, Allogeneic CD56-positive CD3-negative Natural Killer Cells, Allogeneic Hematopoietic Stem Cell Transplantation - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Erythroid Leukemia | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 63 | 2013-06-11 | 2023-11-07 |
| NK Cells in Cord Blood Transplantation Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 1 | Unknown | M.D. Anderson Cancer Center | 13 | 2013-05-03 | 2020-02-11 |
Myelodysplastic Syndromes (12) · Leukemia, Myeloid, Acute (7) · Leukemia, Myelomonocytic, Chronic (7) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (7) · Leukemia, Biphenotypic, Acute (5) · Lymphoma, Non-Hodgkin (5) · Hodgkin Disease (4) · Leukemia, Myeloid, Accelerated Phase (4) · Leukemia, Lymphocytic, Chronic, B-Cell (3) · Leukemia, Myeloid, Chronic-Phase (3) · Anemia, Refractory, with Excess of Blasts (2) · Blast Crisis (2) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (2) · Multiple Myeloma (2) · Neoplasm, Residual (2)
Hematologic Diseases (13) · Hemic and Lymphatic Diseases (13) · Bone Marrow Diseases (12) · Leukemia (12) · Neoplasms (12) · Neoplasms by Histologic Type (12) · Leukemia, Myeloid (10) · Pathologic Processes (10) · Pathological Conditions, Signs and Symptoms (10) · Disease Attributes (9) · Chronic Disease (8) · Immune System Diseases (7) · Immunoproliferative Disorders (7) · Leukemia, Lymphoid (7) · Lymphatic Diseases (7)
Melphalan (5) · Azacitidine (4) · CT-P10 (4) · Cyclophosphamide (4) · Rituximab (4) · Tacrolimus (4) · Whole-Body Irradiation (4) · fludarabine phosphate (4) · venetoclax (4) · Busulfan (3) · Clofarabine (3) · Cord Blood Stem Cell Transplantation (3) · Antilymphocyte Serum (2) · Cytarabine (2) · Filgrastim (2)
M.D. Anderson Cancer Center (7) · Andrew E. Place, MD (1) · City of Hope Medical Center (1) · Orca Biosystems, Inc. (1) · Rutgers, The State University of New Jersey (1) · Uma Borate (1) · University of California, Davis (1) · Vanderbilt-Ingram Cancer Center (1)
United States (14)
Guillermo Garcia-Manero (2) · Amanda Olson (1) · Andrew E Place, MD, PhD (1) · Brian Jonas (1) · Chitra Hosing (1) · Michael Savona, MD (1) · Richard E Champlin (1) · Roger Strair (1) · Samer Khaled (1) · Samer Srour (1) · Sanjay Mohan, MD (1) · Uma M Borate, MD (1) · Warren Fingrut, MD (1)
PMID 36063832, PMID 41385341, PMID 42806776
P30CA016672 (1), P30CA068485 (1), P30CA072720 (1), P30CA093373 (1), R01CA211044 (1)