22 completed, 2 terminated, 1 withdrawn. 10 Phase 2, 6 Phase 1, 3 Not applicable, 3 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 9, Terminated 1 |
| Phase 1 | 6 | Completed 6 |
| Not applicable | 3 | Completed 2, Withdrawn 1 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Early Phase 1 | 1 | Completed 1 |
Follow Stage IVB Cervical Cancer: new trials by email Literature Review of Stage IVB Cervical Cancer trials Research Report on Stage IVB Cervical Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| First-line Treatment With Camrelizumab + Apatinib Versus Chemotherapy + Bevacizumab in Advanced Cervical Cancer Camrelizumab, Apatinib, Paclitaxel - Stage IVB Cervical Cancer, Recurrent Cervical Cancer | Phase 2 | Terminated | Sun Yat-Sen University Cancer Center | 35 | 2021-07-30 | 2026-07-29 |
| Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners Cognitive Behavior Therapy, Quality-of-Life Assessment, Questionnaire Administration - Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm | Not applicable | Completed | Rutgers, The State University of New Jersey | 14 | 2017-12-06 | 2021-04-08 |
| Nanoparticle Albumin-Bound Rapamycin in Treating Patients With Advanced Cancer With mTOR Mutations Laboratory Biomarker Analysis, Nanoparticle Albumin-Bound Rapamycin, Quality-of-Life Assessment - Advanced Malignant Neoplasm, Cervical Squamous Cell Carcinoma | Early Phase 1 | Completed | Mayo Clinic | 2 | 2016-01-01 | 2019-06-06 |
| Axalimogene Filolisbac (ADXS11-001) High Dose in Women With Human Papillomavirus (HPV) + Cervical Cancer Axalimogene filolisbac - Effects of Immunotherapy, Metastatic/Recurrent Cervical Cancer | Phase 1 | Completed | Advaxis, Inc. | 12 | 2015-03-04 | 2024-05-20 |
| Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers educational intervention, telephone-based intervention, quality-of-life assessment - Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter | Not applicable | Completed | City of Hope Medical Center | 200 | 2013-10-29 | 2026-10-01 |
| Eribulin Mesylate in Treating Patients With Advanced or Recurrent Cervical Cancer eribulin mesylate - Recurrent Cervical Cancer, Stage IIIA Cervical Cancer | Phase 2 | Completed | University of Southern California | 32 | 2012-08-09 | 2025-11-06 |
| Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer Filgrastim, Laboratory Biomarker Analysis, Pegfilgrastim - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 27 | 2011-02-01 | 2019-08-08 |
| Patient, Physician, and Nurse Factors Associated With Entry Onto Clinical Trials and Finishing Treatment in Patients With Primary or Recurrent Uterine, Endometrial, or Cervical Cancer Medical Chart Review, Questionnaire Administration - Recurrent Cervical Carcinoma, Recurrent Uterine Corpus Carcinoma | Completed | Gynecologic Oncology Group | 778 | 2010-07-01 | 2018-04-12 | |
| Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors temsirolimus, vinorelbine ditartrate - Extensive Stage Small Cell Lung Cancer, Hereditary Paraganglioma | Phase 1 | Completed | University of Southern California | 19 | 2010-06-01 | 2016-06-13 |
| Temsirolimus in Treating Patients With Cervical Cancer That Is Recurrent, Locally Advanced, Metastatic, or Cannot Be Removed By Surgery Temsirolimus, Laboratory Biomarker Analysis - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 38 | 2009-12-01 | 2015-09-10 |
| Triapine, Cisplatin, and Radiation Therapy in Treating Patients With Cervical Cancer or Vaginal Cancer triapine, cisplatin, external beam radiation therapy - Recurrent Cervical Cancer, Recurrent Vaginal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 26 | 2009-07-01 | 2017-11-17 |
| Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies stereotactic radiosurgery, quality-of-life assessment - Fallopian Tube Cancer, Ovarian Sarcoma | Phase 2 | Completed | Case Comprehensive Cancer Center | 50 | 2009-05-01 | 2013-11-28 |
| Paclitaxel and Cisplatin or Topotecan With or Without Bevacizumab in Treating Patients With Stage IVB, Recurrent, or Persistent Cervical Cancer Bevacizumab, Cisplatin, Laboratory Biomarker Analysis - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 3 | Completed | National Cancer Institute (NCI) | 452 | 2009-04-01 | 2019-07-23 |
| Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer Management of Therapy Complications, Quality-of-Life Assessment - Lymphedema, Stage 0 Cervical Cancer | Phase 3 | Terminated | Gynecologic Oncology Group | 2 | 2007-12-01 | 2021-06-23 |
| FDG and FMISO PET Hypoxia Evaluation in Cervical Cancer 18F-fluoromisonidazole, fluorodeoxyglucose F 18, positron emission tomography - Cervical Adenocarcinoma, Cervical Squamous Cell Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 16 | 2007-11-01 | 2016-12-30 |
| Sunitinib Malate in Treating Patients With Uterine Cervical Cancer That is Stage IVB, Recurrent, or Cannot Be Removed By Surgery sunitinib malate - Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 19 | 2007-01-01 | 2015-02-16 |
| Phase I Study of Intravenous Triapine (IND # 68338) in Combination With Pelvic Radiation Therapy With or Without Weekly Intravenous Cisplatin Chemotherapy for Locally Advanced Cervical, Vaginal, or Pelvic Gynecologic Malignancies triapine, laboratory biomarker analysis, external beam radiation therapy - Recurrent Cervical Cancer, Recurrent Ovarian Epithelial Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2006-03-01 | 2013-01-11 |
| EF5 in Finding Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Cervical, Endometrial, or Ovarian Epithelial Cancer EF5 - Primary Peritoneal Cavity Cancer, Stage I Endometrial Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 60 | 2005-02-01 | 2013-01-16 |
| Comparison of Four Combination Chemotherapy Regimens Using Cisplatin in Treating Patients With Stage IVB, Recurrent, or Persistent Cancer of the Cervix Cisplatin, Gemcitabine Hydrochloride, Paclitaxel - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 3 | Completed | Gynecologic Oncology Group | 513 | 2003-05-01 | 2018-10-17 |
| Oxaliplatin and Paclitaxel in Treating Patients With Locally Recurrent or Metastatic Cervical Cancer Paclitaxel, Oxaliplatin - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 35 | 2003-01-01 | 2015-11-17 |
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Uterine Cervical Neoplasms (25) · Carcinoma, Ovarian Epithelial (8) · Breast Neoplasms (6) · Endometrial Neoplasms (6) · Prostatic Neoplasms (6) · Vaginal Neoplasms (6) · Vulvar Neoplasms (6) · Carcinoma, Non-Small-Cell Lung (4) · Carcinoma, Renal Cell (4) · Colonic Neoplasms (4) · Pancreatic Neoplasms (4) · Rectal Neoplasms (4) · Urinary Bladder Neoplasms (4) · Anus Neoplasms (3) · Breast Neoplasms, Male (3)
Female Urogenital Diseases (25) · Female Urogenital Diseases and Pregnancy Complications (25) · Genital Diseases (25) · Urogenital Diseases (25) · Genital Diseases, Female (24) · Genital Neoplasms, Female (24) · Neoplasms (24) · Neoplasms by Site (24) · Urogenital Neoplasms (24) · Uterine Cervical Diseases (24) · Uterine Diseases (24) · Uterine Neoplasms (23) · Neoplasms by Histologic Type (11) · Adnexal Diseases (10) · Endocrine Gland Neoplasms (10)
Cisplatin (5) · Paclitaxel (4) · Taxes (3) · Topotecan (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (2) · 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (2) · Bevacizumab (2) · Fluorodeoxyglucose F18 (2) · Magnetic Resonance Spectroscopy (2) · Platinum (2) · Vinorelbine (2) · temsirolimus (2) · 7-hydroxystaurosporine (1) · Brachytherapy (1)
National Cancer Institute (NCI) (12) · Gynecologic Oncology Group (4) · University of Southern California (2) · Advaxis, Inc. (1) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · Mayo Clinic (1) · Northwestern University (1) · Rutgers, The State University of New Jersey (1) · Sun Yat-Sen University Cancer Center (1)
United States (21) · Canada (2) · China (1) · Spain (1)
Charles Kunos (3) · Agustin Garcia (1) · Amy Halverson (1) · Anna Tinker (1) · Antonius Miller (1) · Betty Ferrell (1) · Bradley Monk (1) · Christina Chu (1) · Dennis Kuo (1) · Helen Mackay (1) · Joseph Rajendran (1) · Krishnansu Tewari (1) · Levi Downs (1) · Lynda Roman, MD (1) · Michael Cibull (1)
PMID 19931137, PMID 22105720, PMID 24552320, PMID 25638326, PMID 25937529, PMID 28756902, PMID 32847980, PMID 36185311, PMID 36898292
U10CA027469 (3), U10CA180868 (3), U01CA062502 (2), U10CA101165 (2), N01CM37008 (1), N01CM62204 (1), P30CA013330 (1), P30CA015083 (1), P30CA043703 (1), P30CA044579 (1), P30CA072720 (1), R21CA099346 (1), U01CA076576 (1), U10CA031946 (1)