51 active not recruiting, 44 recruiting, 23 completed, 15 terminated. 71 Phase 2, 55 Phase 1, 22 Not applicable, 13 Phase 3, 3 Early Phase 1.
Follow Stage IV Lung Cancer AJCC v8: new trials by email Literature Review of Stage IV Lung Cancer AJCC v8 trials Research Report on Stage IV Lung Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 50 | 2026-12-01 | 2026-09-17 |
| CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung Cancer Adagrasib, Biospecimen Collection, Computed Tomography - Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8 | Phase 2 | Not yet recruiting | Roswell Park Cancer Institute | 29 | 2026-10-15 | 2026-09-02 |
| SX-682 and Atezolizumab for the Treatment of Advanced or Metastatic, Recurrent Non-small Cell Lung Cancer Atezolizumab, CXCR1/2 Inhibitor SX-682, Biospecimen Collection - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | University of Washington | 32 | 2026-10-06 | 2026-10-13 |
| Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2026-10-01 | 2026-08-28 | |
| Treatment for Advanced Non-small Cell Lung Cancer With Actionable Genomic Alterations After Targeted Treatment and Chemotherapy (An Expanded Lung-MAP Treatment Trial) Biospecimen Collection, Computed Tomography, Ivonescimab - Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 2 | Recruiting | SWOG Cancer Research Network | 117 | 2026-09-22 | 2026-10-13 |
| Lumbar Punctures for the Detection of ctDNA in the Cerebrospinal Fluid of Patients With Stage III and IV Non-Small Cell Lung Cancer Biospecimen Collection, Lumbar Puncture, Magnetic Resonance Imaging - Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8 | Not applicable | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 40 | 2026-09-15 | 2026-04-08 |
| A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab Computed Tomography, Copper Cu 64-DOTA-pembrolizumab, Low Dose Radiation Therapy - Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2026-09-01 | 2026-10-19 |
| Photoimmunotherapy With ASP-1929 and Cemiplimab for the Treatment of Refractory, Inoperable, and Metastatic Stage IIIB-IV Non-small Cell Lung Cancer Biospecimen Collection, Cemiplimab, Cetuximab Sarotalocan Sodium - Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Withdrawn | Roswell Park Cancer Institute | 2026-08-15 | 2026-09-15 | |
| Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 37 | 2026-06-17 | 2026-09-04 |
| Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial Adagrasib, Anti-PD-L1 Monoclonal Antibody, Anti-PD1 Monoclonal Antibody - Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8 | Phase 2 | Recruiting | City of Hope Medical Center | 535 | 2026-05-01 | 2026-10-16 |
| Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study Biospecimen Collection, Immune Checkpoint Inhibitor - Advanced Biliary Tract Carcinoma, Advanced Head and Neck Squamous Cell Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 160 | 2026-04-24 | 2026-10-13 |
| GT103 in Combination With Pembrolizumab for the Treatment of Advanced or Metastatic STK11 Mutant Non-Small Cell Lung Cancer Anti-CFH Monoclonal Antibody GT103, Biopsy Procedure, Biospecimen Collection - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 28 | 2026-04-01 | 2026-08-19 |
| Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial) Biospecimen Collection, Cemiplimab, Computed Tomography - Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 2 / Phase 3 | Recruiting | SWOG Cancer Research Network | 378 | 2025-05-22 | 2026-10-09 |
| Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer Biospecimen Collection, Craniospinal Irradiation, Electronic Health Record Review - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 35 | 2025-05-05 | 2025-12-08 |
| Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer Biospecimen Collection, Cemiplimab, Computed Tomography - Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 2 | Withdrawn | City of Hope Medical Center | 2025-04-15 | 2025-05-26 | |
| Diclofenac for the Treatment of Patients With Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy Atezolizumab, Biospecimen Collection, Cemiplimab - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Emory University | 20 | 2025-04-09 | 2026-02-12 |
| Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer Atezolizumab, Biopsy Procedure, Biospecimen Collection - Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 45 | 2025-04-08 | 2026-09-17 |
| Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial Biospecimen Collection, Computed Tomography, Involved-Field Radiation Therapy - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Recruiting | NRG Oncology | 115 | 2025-03-04 | 2026-08-17 |
| Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | University of Washington | 22 | 2025-03-03 | 2026-08-14 |
| Vismodegib and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer Atezolizumab, Biospecimen Collection, Computed Tomography - Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma | Phase 1 | Suspended | Dwight Owen | 24 | 2024-12-31 | 2026-09-18 |
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Lung Neoplasms (153) · Carcinoma, Non-Small-Cell Lung (97) · Neoplasm Metastasis (19) · Melanoma (17) · Brain Neoplasms (12) · Colorectal Neoplasms (12) · Breast Neoplasms (11) · Small Cell Lung Carcinoma (11) · Carcinoma, Renal Cell (10) · Adenocarcinoma of Lung (7) · Carcinoma, Transitional Cell (7) · Ovarian Neoplasms (7) · Triple Negative Breast Neoplasms (7) · Pancreatic Neoplasms (6) · Squamous Cell Carcinoma of Head and Neck (6)
Lung Diseases (152) · Neoplasms by Site (152) · Respiratory Tract Diseases (152) · Respiratory Tract Neoplasms (152) · Thoracic Neoplasms (152) · Neoplasms (151) · Bronchial Neoplasms (104) · Carcinoma, Bronchogenic (104) · Neoplasms by Histologic Type (34) · Skin Diseases (27) · Skin and Connective Tissue Diseases (27) · Neoplasms, Glandular and Epithelial (26) · Carcinoma (24) · Pathological Conditions, Signs and Symptoms (22) · Digestive System Diseases (21)
Specimen Handling (55) · Magnetic Resonance Spectroscopy (54) · pembrolizumab (24) · Biopsy (19) · Nivolumab (17) · Immunoglobulin G (15) · atezolizumab (15) · Carboplatin (14) · Disulfides (14) · osimertinib (14) · Pemetrexed (12) · Radiosurgery (10) · Ramucirumab (10) · Radiation (9) · Radiotherapy (8)
M.D. Anderson Cancer Center (28) · National Cancer Institute (NCI) (24) · SWOG Cancer Research Network (13) · City of Hope Medical Center (12) · Mayo Clinic (11) · Ohio State University Comprehensive Cancer Center (9) · Emory University (7) · University of Washington (7) · Roswell Park Cancer Institute (5) · Dwight Owen (4) · NRG Oncology (4) · Fred Hutchinson Cancer Center (3) · OHSU Knight Cancer Institute (3) · Jonsson Comprehensive Cancer Center (2) · Rutgers, The State University of New Jersey (2)
United States (145) · Canada (5) · Guam (2) · Hong Kong (2) · Puerto Rico (2) · China (1) · Ireland (1) · Uganda (1)
Jonathan W Riess (4) · Arya Amini (3) · Yasir Y Elamin, MD (3) · Conor E Steuer (2) · Dwight H Owen, MD (2) · Karen L Reckamp (2) · Kathrin Milbury (2) · Konstantinos Leventakos, M.D., Ph.D. (2) · Liza C Villaruz (2) · Paul K Paik (2) · Ravi Salgia, MD (2) · Sarah B Goldberg (2) · Vinai Gondi (2) · Xiuning Le (2) · Yasir Y Elamin (2)
PMID 31154457, PMID 33067126, PMID 33909232, PMID 34036820, PMID 34562230, PMID 34663123, PMID 34965890, PMID 35080914, PMID 35613998, PMID 36997799, PMID 37129197, PMID 38106014, PMID 38152395, PMID 38197040, PMID 38572955, PMID 39038917, PMID 39356983, PMID 39721752, PMID 39816915, PMID 39886125, PMID 39903538, PMID 39945382, PMID 40580957, PMID 41206673, PMID 41680482, PMID 42161344, PMID 42183367, PMID 42548403, PMID 42687919, PMID 42830627, PMID 42847673, PMID 42868120
U10CA180888 (13), P30CA033572 (11), P30CA138292 (7), U10CA180820 (4), U10CA180868 (4), UM1CA186691 (4), UM1CA186717 (4), P30CA093373 (3), UM1CA186689 (3), UM1CA186690 (3), P30CA012197 (2), P30CA014089 (2), P30CA060553 (2), P30CA072720 (2), P50CA228944 (2)