6 recruiting, 5 active not recruiting, 2 withdrawn, 1 completed. 8 Phase 2, 3 Phase 3, 2 Not applicable, 2 Phase 1.
Follow Stage IV Hypopharyngeal Carcinoma AJCC v8: new trials by email Literature Review of Stage IV Hypopharyngeal Carcinoma AJCC v8 trials Research Report on Stage IV Hypopharyngeal Carcinoma AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation Audiometric Test, Interview - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Cutaneous Squamous Cell Carcinoma of the Head and Neck | Not applicable | Recruiting | Emory University | 118 | 2025-08-25 | 2026-07-16 |
| TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer Autologous Tumor Membrane Vesicles Vaccine, Biospecimen Collection, Computed Tomography - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | Emory University | 40 | 2025-05-08 | 2026-03-04 |
| Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment Biospecimen Collection, Cetuximab, Computed Tomography - Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 158 | 2025-03-27 | 2026-10-26 |
| Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial Biospecimen Collection, Computed Tomography, Lovastatin - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Human Papillomavirus-Related Neck Squamous Cell Carcinoma of Unknown Primary | Phase 2 | Recruiting | Emory University | 28 | 2024-12-09 | 2026-02-11 |
| Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer Biospecimen Collection, Carboplatin, Chest Radiography - Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma | Phase 2 | Withdrawn | ECOG-ACRIN Cancer Research Group | 2024-04-12 | 2024-07-25 | |
| Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck Carboplatin, Cisplatin, Computed Tomography - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma | Phase 3 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 290 | 2023-06-08 | 2026-09-14 |
| Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers Atezolizumab, Bevacizumab, Biospecimen Collection - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma | Phase 2 / Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 430 | 2023-03-13 | 2026-10-01 |
| BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study Biopsy Procedure, Biospecimen Collection, Cabozantinib S-malate - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 150 | 2022-12-06 | 2026-10-26 |
| A Pneumatic Compression Device for the Treatment of Lymphedema in Patients With Stage II-IV Head and Neck Cancer After Chemoradiation Best Practice, Consensus Auditory-Perceptual Evaluation of Voice, Diagnostic Imaging - Clinical Stage II HPV-Mediated (p16-pos) Oropharyngeal Carcinoma, Clinical Stage III HPV-Mediated (p16-pos) Oropharyngeal Carcinoma | Not applicable | Withdrawn | Mayo Clinic | 2022-12-01 | 2023-01-06 | |
| Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck Biopsy Procedure, Biospecimen Collection, Computed Tomography - Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Squamous Cell Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 52 | 2022-07-26 | 2026-09-21 |
| Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer Biospecimen Collection, Computed Tomography, Elimusertib - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 7 | 2022-07-06 | 2026-08-21 |
| Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck Carboplatin, Cemiplimab, Paclitaxel - Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma | Phase 2 | Active not recruiting | Marcelo Bonomi | 46 | 2021-11-30 | 2026-06-25 |
| Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin Cisplatin, Hearing Handicap Inventory for Adults - Screening, Radiation Therapy - Clinical Stage III Human Papillomavirus (HPV)-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Completed | Hyunseok Kang, MD | 16 | 2020-10-14 | 2024-06-28 |
| Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer Celecoxib, Placebo, Quality-of-Life Assessment - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Terminated | University of Utah | 13 | 2019-11-27 | 2025-02-12 |
| Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer Biospecimen Collection, Questionnaire Administration - Carcinoma of Unknown Primary, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Recruiting | M.D. Anderson Cancer Center | 471 | 2016-12-29 | 2026-10-06 |
Hypopharyngeal Neoplasms (15) · Laryngeal Neoplasms (15) · Carcinoma (14) · Mouth Neoplasms (14) · Oropharyngeal Neoplasms (12) · Squamous Cell Carcinoma of Head and Neck (11) · Nasopharyngeal Carcinoma (5) · Lymphoid Interstitial Pneumonia (1) · Melanoma (1) · Neoplasms, Unknown Primary (1) · Paranasal Sinus Neoplasms (1) · Recurrence (1) · Salivary Gland Neoplasms (1)
Head and Neck Neoplasms (15) · Laryngeal Diseases (15) · Neoplasms (15) · Neoplasms by Histologic Type (15) · Neoplasms by Site (15) · Neoplasms, Glandular and Epithelial (15) · Otorhinolaryngologic Diseases (15) · Otorhinolaryngologic Neoplasms (15) · Pharyngeal Diseases (15) · Pharyngeal Neoplasms (15) · Respiratory Tract Diseases (15) · Respiratory Tract Neoplasms (15) · Stomatognathic Diseases (15) · Mouth Diseases (14) · Carcinoma, Squamous Cell (11)
Magnetic Resonance Spectroscopy (8) · Specimen Handling (8) · pembrolizumab (6) · 1,2-diaminocyclohexaneplatinum II citrate (4) · Carboplatin (4) · Cisplatin (4) · Platinum (3) · (225)Ac-DOTA-c(RGDyK) (2) · Biopsy (2) · Cetuximab (2) · Paclitaxel (2) · Radiation (2) · Radiotherapy (2) · Taxes (2) · X-Rays (2)
National Cancer Institute (NCI) (5) · Emory University (3) · ECOG-ACRIN Cancer Research Group (2) · Hyunseok Kang, MD (1) · M.D. Anderson Cancer Center (1) · Marcelo Bonomi (1) · Mayo Clinic (1) · University of Utah (1)
United States (13)
Aarti Bhatia (1) · David J Sher (1) · Dong M. Shin, MD, FACP, FAAAS (1) · Eileen H Shinn (1) · Heath D Skinner (1) · Hyunseok Kang, MD (1) · Jacob S Thomas (1) · Lisa Crujido (1) · Marcelo R Bonomi, MD (1) · Nicole C Schmitt, D, FACS (1) · Nicole C Schmitt, MD, FACS (1) · Richard Cannon, MD (1) · Siddharth Sheth (1) · Siwen Hu-Lieskovan (1) · Yvonne M Mowery (1)
P30CA138292 (3), U10CA180820 (3), K24DC022077 (1), P30CA042014 (1), R01CA262123 (1), R21DE019954 (1), U10CA180821 (1), U10CA180888 (1), UM1CA186690 (1), UM1CA186717 (1)