10 active not recruiting, 5 completed, 4 recruiting, 3 terminated. 12 Phase 2, 8 Not applicable, 2 Early Phase 1, 2 Phase 3, 1 Phase 1.
Follow Stage IIC Prostate Cancer AJCC v8: new trials by email Literature Review of Stage IIC Prostate Cancer AJCC v8 trials Research Report on Stage IIC Prostate Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Androgen Deprivation Therapy (Relugolix) for the Improvement of Diagnostic Imaging (PSMA PET/CT Scan) in Patients With High Risk or Very High Risk Prostate Cancer, The EnrichPSMA Trial Biospecimen Collection, Computed Tomography, Flotufolastat F-18 Gallium - Prostate Adenocarcinoma, Stage IIC Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 30 | 2025-08-25 | 2026-09-23 |
| Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate Cancer Biospecimen Collection, Contrast Agent, Leuprolide - Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 70 | 2024-08-12 | 2026-03-09 |
| SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma Antiandrogen Therapy, Biospecimen Collection, Hypofractionated Radiation Therapy - Biochemically Recurrent Prostate Carcinoma, Oligometastatic Prostate Carcinoma | Phase 3 | Active not recruiting | Mayo Clinic | 118 | 2024-04-04 | 2026-09-17 |
| Relugolix in Combination With Radiation Therapy for Treating Patients With High Risk Prostate Cancer Biospecimen Collection, Bone Scan, Brachytherapy - Stage IIC Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8 | Phase 2 | Not yet recruiting | University of Kansas Medical Center | 90 | 2023-11-20 | 2023-11-13 |
| RElugolix VErsus LeUprolide Cardiac Trial Radiation therapy, Leuprolide, Relugolix - Biochemically Recurrent Prostate Carcinoma, Localized Prostate Carcinoma | Phase 2 | Active not recruiting | Emory University | 94 | 2022-06-06 | 2026-02-12 |
| Robot-Assisted Radical Prostatectomy With or Without Vesicopexy in Patients With Prostate Cancer Quality-of-Life Assessment, Questionnaire Administration, Radical Prostatectomy - Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8 | Not applicable | Suspended | University of Southern California | 196 | 2021-10-27 | 2026-06-01 |
| Pharmacokinetics of IA and IV Ga68-PSMA-11 Infusion Angiogram, Catheterization, Gallium Ga-labeled PSMA-11 - Prostate Adenocarcinoma, Prostate Carcinoma | Early Phase 1 | Completed | Ryan Kohlbrenner, MD | 5 | 2021-10-13 | 2023-04-07 |
| Neoadjuvant Dietary Intervention in Intermediate Risk Prostate Cancer Dietary Intervention, Radical Prostatectomy - Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Active not recruiting | M.D. Anderson Cancer Center | 12 | 2021-08-27 | 2026-09-18 |
| High Dose-Rate Brachytherapy and Stereotactic Body Radiotherapy for the Treatment of Prostate Adenocarcinoma High-Dose Rate Brachytherapy, Stereotactic Body Radiation Therapy - Prostate Adenocarcinoma, Stage IIB Prostate Cancer American Joint Committee on Cancer (AJCC) v8 | Not applicable | Recruiting | Jonsson Comprehensive Cancer Center | 52 | 2021-08-20 | 2026-08-20 |
| Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer Abiraterone Acetate, Antiandrogen Therapy, Apalutamide - Prostate Carcinoma, Stage IIC Prostate Cancer AJCC v8 | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 200 | 2021-08-05 | 2026-06-23 |
| An Investigational Scan (68Ga-PSMA-11 PET) for the Imaging of Prostate Cancer Computed Tomography, Gallium Ga 68 Gozetotide, Positron Emission Tomography - Biochemically Recurrent Prostate Carcinoma, Metastatic Castration-Resistant Prostate Carcinoma | Phase 2 | Active not recruiting | University of Washington | 141 | 2021-05-17 | 2026-01-09 |
| White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA Clinical Observation, Patient Observation, Questionnaire Administration - Prostate Adenocarcinoma, PSA Failure | Phase 2 | Suspended | City of Hope Medical Center | 133 | 2021-05-10 | 2026-08-10 |
| Health Literacy in Understanding Radiation Therapy Information in Patients Undergoing Definitive Radiation Therapy Survey Administration - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Terminated | University of Southern California | 35 | 2020-12-18 | 2024-04-29 | |
| Germline DNA-Based Radiosensitivity Biomarker Influence on Toxicity Following Prostate Radiotherapy, GARUDA Trial Discussion, Hypofractionated Radiation Therapy, Laboratory Biomarker Analysis - Prostate Adenocarcinoma, Stage I Prostate Cancer American Joint Committee on Cancer (AJCC) v8 | Not applicable | Active not recruiting | Jonsson Comprehensive Cancer Center | 208 | 2020-11-10 | 2026-07-07 |
| Randomized Trial of PSMA PET Scan Before Definitive Radiation Therapy for Prostate Cancer Computed Tomography, Fluorine F 18 DCFPyL, Positron Emission Tomography - Stage I Prostate Cancer American Joint Committee on Cancer (AJCC) v8, Stage II Prostate Cancer AJCC v8 | Phase 3 | Terminated | Jonsson Comprehensive Cancer Center | 54 | 2020-08-14 | 2023-01-17 |
| An Investigational Scan (7 Tesla MRI) in Diagnosing Cognitive Impairment in Patients With Non-Metastatic Prostate Cancer 7 Tesla Magnetic Resonance Imaging - Non-Metastatic Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Completed | University of Southern California | 20 | 2020-08-11 | 2025-03-17 |
| Remote Telemonitoring of Patient-Generated Physiologic Health Data and Patient-Reported Outcomes Patient Monitoring, Questionnaire Administration - Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8, Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8 | Completed | City of Hope Medical Center | 22 | 2020-08-11 | 2026-10-14 | |
| Focal Radiation Therapy for the Treatment of Low or Intermediate-Risk Prostate Cancer High-Dose Rate Brachytherapy, Quality-of-Life Assessment, Questionnaire Administration - Prostate Adenocarcinoma, Stage I Prostate Cancer American Joint Committee on Cancer (AJCC) v8 | Not applicable | Withdrawn | Jonsson Comprehensive Cancer Center | 2020-04-03 | 2020-11-06 | |
| Lifestyle Behavior Influences Among African American Patients With Stage 0-III Prostate Cancer Survivors and Their Partners Accelerometer, Ecological Momentary Assessment, Questionnaire Administration - Cancer Survivor, Partner | Active not recruiting | M.D. Anderson Cancer Center | 200 | 2020-02-26 | 2026-08-21 | |
| Daily, Long-Term Intermittent Fasting for the Prevention of PSA-Recurrence in Patients With Localized Prostate Cancer After Radical Prostatectomy Food Diary, Preventative Dietary Intervention, Questionnaire Administration - Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8 | Early Phase 1 | Withdrawn | Mayo Clinic | 2020-01-08 | 2022-07-11 |
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Prostatic Neoplasms (27) · Carcinoma, Renal Cell (1) · Colorectal Neoplasms (1) · Gastrointestinal Neoplasms (1) · Neoplasms (1) · Ovarian Neoplasms (1) · Urinary Bladder Neoplasms (1) · Urogenital Neoplasms (1) · Uterine Cervical Neoplasms (1)
Genital Diseases (27) · Genital Diseases, Male (27) · Genital Neoplasms, Male (27) · Male Urogenital Diseases (27) · Neoplasms by Site (27) · Prostatic Diseases (27) · Urogenital Diseases (27) · Neoplasms (26) · Urogenital Neoplasms (26) · Adenocarcinoma (1) · Adnexal Diseases (1) · Carcinoma (1) · Colonic Diseases (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1)
Magnetic Resonance Spectroscopy (7) · Brachytherapy (5) · Radiosurgery (5) · Radiation (4) · Specimen Handling (4) · relugolix (4) · Radiotherapy (3) · Abiraterone Acetate (2) · Androgen Antagonists (2) · Gonadotropin-Releasing Hormone (2) · Leuprolide (2) · Prednisone (2) · Radiation Dose Hypofractionation (2) · Radiotherapy, Intensity-Modulated (2) · apalutamide (2)
M.D. Anderson Cancer Center (6) · Jonsson Comprehensive Cancer Center (4) · Mayo Clinic (3) · University of Southern California (3) · City of Hope Medical Center (2) · University of Washington (2) · Emory University (1) · NRG Oncology (1) · Ohio State University Comprehensive Cancer Center (1) · Roswell Park Cancer Institute (1) · Rutgers, The State University of New Jersey (1) · Ryan Kohlbrenner, MD (1) · University of Kansas Medical Center (1)
United States (27) · Canada (1)
Dalnim Cho (2) · Alan C Lee (1) · Amar Kishan (1) · Carlos E. Vargas, MD (1) · Christopher Logothetis (1) · Clayton S Lau (1) · Delphine L. Chen, M.D. (1) · Gurkamal S Chatta (1) · Hooman Djaladat, MD (1) · Jack R. Andrews, MD (1) · Jeremie Calais (1) · Justin R Gregg (1) · Kimberly Miller, MD (1) · Laleh Melstrom (1) · Lara Hathout (1)
PMID 33962579, PMID 38664019, PMID 39136560, PMID 39254446, PMID 39390760, PMID 41202201, PMID 41706486
P30CA014089 (3), P30CA033572 (2), P30CA015083 (1), P30CA015704 (1), P30CA016672 (1), P30CA072720 (1), P30CA138292 (1), P30CA168524 (1), P50CA140388 (1), U10CA180868 (1)