19 completed, 7 terminated, 1 active not recruiting. 16 Phase 2, 10 Phase 1, 2 Early Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 12, Terminated 4 |
| Phase 1 | 10 | Completed 5, Terminated 5 |
| Early Phase 1 | 2 | Completed 2 |
| Not applicable | 2 | Completed 2 |
Follow Stage I Small Lymphocytic Lymphoma: new trials by email Literature Review of Stage I Small Lymphocytic Lymphoma trials Research Report on Stage I Small Lymphocytic Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lenalidomide in Improving Immune Response to Vaccine Therapy in Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Monoclonal B Cell Lymphocytosis Laboratory Biomarker Analysis, Lenalidomide, Pneumococcal 13-valent Conjugate Vaccine - Monoclonal B-Cell Lymphocytosis, Stage 0 Chronic Lymphocytic Leukemia | Phase 2 | Terminated | Mayo Clinic | 12 | 2015-06-11 | 2021-01-19 |
| Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma curcumin, cholecalciferol, laboratory biomarker analysis - Contiguous Stage II Small Lymphocytic Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma | Phase 2 | Completed | Paolo Caimi, MD | 35 | 2014-10-16 | 2024-04-12 |
| Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas lenalidomide, etoposide, prednisone - Adult Grade III Lymphomatoid Granulomatosis, B-cell Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | Completed | University of Chicago | 55 | 2014-07-29 | 2026-03-11 |
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| Phase II MOR00208 in Combination With Lenalidomide for Patients With Relapsed or Refractory CLL, SLL or PLL or Older Patients With Untreated CLL, SLL or PLL MOR00208, lenalidomide, Correlative Studies - Contiguous Stage II Small Lymphocytic Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma | Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 41 | 2014-01-17 | 2025-12-15 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas brentuximab vedotin, rituximab, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Terminated | Northwestern University | 20 | 2013-03-05 | 2021-09-01 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Bortezomib and Filgrastim to Promote Stem Cell Mobilization in Patients With Non-Hodgkin Lymphoma or Multiple Myeloma bortezomib, filgrastim, autologous hematopoietic stem cell transplantation - Adult Grade III Lymphomatoid Granulomatosis, B-cell Chronic Lymphocytic Leukemia | Not applicable | Completed | Barbara Ann Karmanos Cancer Institute | 23 | 2011-07-01 | 2021-05-10 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Wake Forest University Health Sciences | 16 | 2011-01-01 | 2018-09-07 |
| Cyclophosphamide, Alvocidib, and Rituximab in Treating Patients With High Risk B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Alvocidib Hydrochloride, Cyclophosphamide, Diagnostic Laboratory Biomarker Analysis - Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 9 | 2010-04-01 | 2015-11-11 |
| Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Cyclophosphamide, Laboratory Biomarker Analysis, Ofatumumab - Chronic Lymphocytic Leukemia, Stage 0 Chronic Lymphocytic Leukemia | Phase 2 | Completed | Mayo Clinic | 82 | 2010-03-01 | 2018-09-18 |
| Lenalidomide And Rituximab as Maintenance Therapy in Treating Patients With B-Cell Non-Hodgkin Lymphoma lenalidomide, rituximab, polymerase chain reaction - Adult Non-Hodgkin Lymphoma, Adult Grade III Lymphomatoid Granulomatosis | Phase 1 | Terminated | Case Comprehensive Cancer Center | 5 | 2010-01-01 | 2015-11-26 |
| Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer rituximab, mycophenolate mofetil, tacrolimus - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Terminated | University of Nebraska | 20 | 2009-12-10 | 2023-09-06 |
| Gossypol, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery R-(-)-gossypol acetic acid, paclitaxel, carboplatin - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 36 | 2009-07-01 | 2013-01-10 |
| Vorinostat, Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Fludarabine Phosphate, Cyclophosphamide, Rituximab - Chronic Lymphocytic Leukemia, Stage I Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2009-06-01 | 2020-02-25 |
| Pegfilgrastim and Rituximab in Treating Patients With Untreated, Relapsed, or Refractory Follicular Lymphoma, Small Lymphocytic Lymphoma, or Marginal Zone Lymphoma pegfilgrastim, rituximab, flow cytometry - Contiguous Stage II Grade 1 Follicular Lymphoma, Contiguous Stage II Grade 2 Follicular Lymphoma | Phase 2 | Completed | Roswell Park Cancer Institute | 20 | 2007-04-17 | 2017-10-09 |
| Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer beclomethasone dipropionate, placebo, tacrolimus - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 140 | 2007-04-01 | 2021-02-03 |
| Alvocidib in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma alvocidib, pharmacological study, laboratory biomarker analysis - B-cell Chronic Lymphocytic Leukemia, Contiguous Stage II Small Lymphocytic Lymphoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 24 | 2006-09-01 | 2013-07-02 |
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Leukemia, Lymphocytic, Chronic, B-Cell (27) · Lymphoma, B-Cell, Marginal Zone (20) · Lymphoma, Follicular (20) · Lymphoma, Mantle-Cell (19) · Lymphoma, Large B-Cell, Diffuse (18) · Waldenstrom Macroglobulinemia (18) · Burkitt Lymphoma (16) · Lymphoma, Non-Hodgkin (16) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (16) · Lymphoma, Large-Cell, Immunoblastic (15) · Hodgkin Disease (13) · Leukemia, Hairy Cell (10) · Lymphoma, Extranodal NK-T-Cell (10) · Lymphoma, T-Cell, Cutaneous (10) · Mycosis Fungoides (10)
Chronic Disease (27) · Disease Attributes (27) · Hematologic Diseases (27) · Hemic and Lymphatic Diseases (27) · Immune System Diseases (27) · Immunoproliferative Disorders (27) · Leukemia, B-Cell (27) · Leukemia, Lymphoid (27) · Lymphatic Diseases (27) · Lymphoproliferative Disorders (27) · Neoplasms (27) · Neoplasms by Histologic Type (27) · Pathologic Processes (27) · Pathological Conditions, Signs and Symptoms (27) · Leukemia (26)
Rituximab (10) · Cyclophosphamide (7) · fludarabine phosphate (7) · Peripheral Blood Stem Cell Transplantation (6) · Mycophenolic Acid (5) · Tacrolimus (5) · Whole-Body Irradiation (5) · Lenalidomide (4) · Cyclosporine (3) · Flow Cytometry (3) · alvocidib (3) · Busulfan (2) · Etoposide (2) · Filgrastim (2) · Granulocyte Colony-Stimulating Factor (2)
National Cancer Institute (NCI) (7) · Fred Hutchinson Cancer Center (6) · Case Comprehensive Cancer Center (2) · City of Hope Medical Center (2) · Mayo Clinic (2) · Barbara Ann Karmanos Cancer Institute (1) · Northwestern University (1) · Ohio State University Comprehensive Cancer Center (1) · Paolo Caimi, MD (1) · Roswell Park Cancer Institute (1) · University of Chicago (1) · University of Nebraska (1) · Wake Forest University Health Sciences (1)
United States (27) · Italy (2) · Denmark (1) · Germany (1)
Brenda Sandmaier (2) · Ryotaro Nakamura (2) · Tait Shanafelt (2) · Adam Petrich, MD (1) · Ajay Gopal (1) · Ann Woolfrey (1) · Brian Hill, MD (1) · David Maloney (1) · Divaya Bhutani, M.D. (1) · Francisco Hernandez-ILizaliturri (1) · Jennifer Woyach, MD (1) · John Byrd (1) · Joseph Flynn (1) · Leslie Andritsos (1) · Lode Swinnen (1)
PMID 32499241, PMID 18698002, PMID 19900571, PMID 24431228, PMID 25085357, PMID 26853648, PMID 27118540, PMID 27570087, PMID 30562587, PMID 31388792, PMID 40720747
P30CA015704 (5), P01CA018029 (3), U01CA076576 (3), P30CA015083 (2), P01CA078902 (1), P30CA014599 (1), P30CA016058 (1), P30CA022453 (1), P30CA036727 (1), P30CA043703 (1), P30CA046592 (1), R21CA119519 (1), U01CA132194 (1)