4 completed, 2 recruiting, 1 active not recruiting. 7 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Recruiting 2, Active not recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow Soft Tissue Neoplasms: new trials by email Literature Review of Soft Tissue Neoplasms trials Research Report on Soft Tissue Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| QL1706 in the Treatment of Advanced Bone and Soft Tissue Sarcoma QL1706 (bispecific antibody targeting PD-1 and CLTA-4) - Bone and Soft Tissue Tumors | Phase 2 | Recruiting | Sun Yat-sen University | 45 | 2025-09-28 | 2025-11-19 |
| (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis bezuclastinib - Advanced Systemic Mastocytosis (AdvSM), SM With an Associated Hematologic Neoplasm (SM-AHN) | Phase 2 | Recruiting | Cogent Biosciences, Inc. | 140 | 2021-11-09 | 2026-09-15 |
| Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma Subtypes Durvalumab, Tremelimumab - Advanced and/or Metastatic Sarcoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 57 | 2016-08-16 | 2025-06-12 |
| Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic Laboratory Biomarker Analysis, Pembrolizumab, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Carcinoma of Unknown Primary | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 157 | 2016-08-15 | 2026-07-17 |
| Study of MEK162 for Children With Low-Grade Gliomas MEK162 - Low-Grade Gliomas, Malignant Neoplasms, Brain | Phase 1 / Phase 2 | Completed | Children's Hospital Los Angeles | 105 | 2016-05-04 | 2025-10-07 |
| Trabectedin First Line Therapy In Unfit Sarcoma Study Trabectedin - Metastatic and Locally Advanced Soft Tissue Tumor Patients Unfit to Receive, Standard Chemotherapy | Phase 2 | Completed | Italian Sarcoma Group | 24 | 2014-02-01 | 2018-04-11 |
| Isolated Limb Perfusion of Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Soft Tissue Sarcoma of the Arm or Leg melphalan, tumor necrosis factor - Stage IVB Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma | Phase 2 | Completed | National Institutes of Health Clinical Center (CC) | 1999-08-01 | 2023-10-31 |
Neoplasm Metastasis (2) · Neoplasms (2) · Vascular Neoplasms (2) · Adrenal Cortex Neoplasms (1) · Brain Neoplasms (1) · Carcinoma, Renal Cell (1) · Carcinoma, Small Cell (1) · Hemangioendothelioma, Epithelioid (1) · Hemangiosarcoma (1) · Hematologic Diseases (1) · Hematologic Neoplasms (1) · Histiocytoma, Malignant Fibrous (1) · Hypersensitivity (1) · Immune Complex Diseases (1)
Neoplasms by Site (6) · Neoplasms (5) · Neoplasms by Histologic Type (4) · Neoplasms, Connective and Soft Tissue (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Cardiovascular Diseases (2) · Neoplastic Processes (2) · Vascular Diseases (2) · Adenocarcinoma (1) · Adrenal Cortex Diseases (1) · Adrenal Gland Diseases (1) · Adrenal Gland Neoplasms (1) · Bone Marrow Diseases (1)
Melphalan (1) · Trabectedin (1) · Tumor Necrosis Factor-alpha (1) · binimetinib (1) · durvalumab (1) · pembrolizumab (1) · tremelimumab (1)
M.D. Anderson Cancer Center (2) · Children's Hospital Los Angeles (1) · Cogent Biosciences, Inc. (1) · Italian Sarcoma Group (1) · National Institutes of Health Clinical Center (CC) (1) · Sun Yat-sen University (1)
United States (4) · Italy (2) · Australia (1) · Austria (1) · Belgium (1) · Canada (1) · China (1) · France (1) · Germany (1) · Netherlands (1) · Norway (1) · Poland (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Aung Naing (1) · Federica Grosso, MD (1) · H. Richard Alexander, Jr. (1) · Nathan Robison, MD (1) · Neeta Somaiah, MBBS (1) · Rachael Easton, MD, Ph.D. (1)
PMID 31533818, PMID 32188704, PMID 32303619, PMID 32534809, PMID 33415580, PMID 33427689, PMID 33491277, PMID 33770291, PMID 34241781, PMID 34725215, PMID 35618285, PMID 35934010, PMID 35999229, PMID 37568622, PMID 40212844, PMID 41143139, PMID 42342409