11 completed, 5 unknown, 1 active not recruiting, 1 recruiting. 8 Not applicable, 3 Phase 1, 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 4, Unknown 4 |
| Phase 1 | 3 | Completed 2, Active not recruiting 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
Follow Tumor Necrosis Factor-alpha: new trials by email Literature Review of Tumor Necrosis Factor-alpha trials Research Report on Tumor Necrosis Factor-alpha
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Host Dysregulation-Driven Sepsis Prediction Model Tumor Necrosis Factor, Interleukin-1β, Interleukin-12 - Sepsis | Completed | Second Affiliated Hospital of Wenzhou Medical University | 1000 | 2024-09-01 | 2024-10-31 | |
| Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1 TILT-123, Avelumab - Melanoma, Head and Neck Squamous Cell Carcinoma | Phase 1 | Active not recruiting | TILT Biotherapeutics Ltd. | 15 | 2023-03-08 | 2026-10-13 |
| Influence of HLA-DQA1*05 Genotype in Adults With Anti-TNF Treatment With Proactive Therapeutic Drug Monitoring. Tumor necrosis factor (TNF)-alpha inhibitors - Drug Monitoring, Inflammatory Bowel Diseases | Unknown | Hospital del Rio Hortega | 280 | 2023-01-11 | 2023-08-14 | |
| The 1st Tumor CytokinoTherapy Database (TCTD-1) Tumor necrosis factor alpha, Interferon gamma - Oncology | Recruiting | OncoCareClinic 308 Ltd | 5000 | 2022-09-19 | 2024-06-10 | |
| TNFα and IL-2 Coding Oncolytic Adenovirus TILT-123 Monotherapy TILT-123 - Solid Tumor | Phase 1 | Completed | TILT Biotherapeutics Ltd. | 32 | 2021-01-11 | 2026-03-06 |
| Contribution of a Non Medicamentous Approach by Hypnosis on Quality of Life in Crohn Disease immunosuppressor/TNFalpha, Hypnosis - Crohn Disease | Not applicable | Unknown | University Hospital, Grenoble | 40 | 2018-11-13 | 2020-03-23 |
| Mother-caregivers of Children With Duchenne Muscular Dystrophy sleep parameters, Hormonal profile, Inflammatory profile - Other Diseases or Conditions | Not applicable | Completed | Monica Levy Andersen | 60 | 2013-08-01 | 2016-02-03 |
| Endotoxin & Cytokines. Do Protein Loss and Metabolic Effects Depend on Central Nervous System (CNS) Activation of Stress Hormones or on Local Mechanisms in Muscle and Fat? TNF-alpha, Endotoxin - Inflammation, Glucose Metabolism Disorders | Not applicable | Completed | Aarhus University Hospital | 24 | 2010-06-01 | 2013-01-30 |
| Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease TNF-alpha and IL-10 - Hepatitis C Virus Infection, Chronic Liver Disease | Not applicable | Unknown | Kaohsiung Medical University Chung-Ho Memorial Hospital | 2007-01-01 | 2008-03-06 | |
| Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease TNF-alpha and HBV genotype, TNF-alpha and HBV genotypes - Chronic Liver Disease, Hepatocellular Carcinoma | Not applicable | Unknown | Kaohsiung Medical University Chung-Ho Memorial Hospital | 2007-01-01 | 2008-03-06 | |
| Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma Polymorphism of IL-1 beta and TNF-alpha - Hepatitis B, Hepatocellular Carcinoma | Not applicable | Completed | Kaohsiung Medical University Chung-Ho Memorial Hospital | 300 | 2007-01-01 | 2013-04-18 |
| The Acute Effects of Low-dose TNF-α on Glucose Metabolism and β-cell Function in Humans Low-dose TNF-alpha - Diabetes Type 2 | Not applicable | Completed | Copenhagen University Hospital, Rigshospitalet | 2006-04-01 | 2013-10-01 | |
| Cytokine Gene Polymorphisms in Gastric Diseases IL-1, TNF-alpha, Il-10 - Gastric Ulcer, Duodenal Ulcer | Not applicable | Unknown | Hamamatsu University | 2000-01-01 | 2005-09-20 | |
| Isolated Limb Perfusion of Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Soft Tissue Sarcoma of the Arm or Leg melphalan, tumor necrosis factor - Stage IVB Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma | Phase 2 | Completed | National Institutes of Health Clinical Center (CC) | 1999-08-01 | 2023-10-31 | |
| Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Locally Advanced Melanoma of the Arm or Leg isolated limb perfusion, melphalan, recombinant tumor necrosis factor family protein - Recurrent Melanoma, Stage III Melanoma | Phase 3 | Completed | National Cancer Institute (NCI) | 216 | 1999-03-01 | 2013-07-16 |
| A Randomized Phase III Trial of Hyperthermic Isolated Limb Perfusion With Melphalan, Tumor Necrosis Factor, and Interferon-Gamma in Patients With Locally Advanced Extremity Melanoma melphalan, tumor necrosis factor, interferon-gamma - Melanoma | Phase 3 | Completed | National Cancer Institute (NCI) | 122 | 1992-02-01 | 2008-03-04 |
| A Study of Tumor Necrosis Factor and Human Interferon-gamma in Patients With AIDS Related Complex Tumor Necrosis Factor, Interferon gamma-1b - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2021-11-04 | |
| A Phase I/II Study of Intralesional Recombinant Tumor Necrosis Factor in Patients With AIDS-Related Cutaneous Kaposi's Sarcoma Tumor Necrosis Factor - Sarcoma, Kaposi, HIV Infections | Phase 1 | Completed | University of California, San Francisco | 2005-06-24 |
Melanoma (3) · Acquired Immunodeficiency Syndrome (2) · Carcinoma, Hepatocellular (2) · HIV Infections (2) · Neoplasms (2) · AIDS-Related Complex (1) · Adenoviridae Infections (1) · Crohn Disease (1) · Diabetes Mellitus, Type 2 (1) · Duodenal Ulcer (1) · Glucose Metabolism Disorders (1) · Hepatitis B (1) · Hepatitis C (1) · Inflammation (1) · Inflammatory Bowel Diseases (1)
Kaohsiung Medical University Chung-Ho Memorial Hospital (3) · National Cancer Institute (NCI) (2) · TILT Biotherapeutics Ltd. (2) · Aarhus University Hospital (1) · Copenhagen University Hospital, Rigshospitalet (1) · Hamamatsu University (1) · Hospital del Rio Hortega (1) · Monica Levy Andersen (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Institutes of Health Clinical Center (CC) (1) · OncoCareClinic 308 Ltd (1) · Second Affiliated Hospital of Wenzhou Medical University (1) · University Hospital, Grenoble (1) · University of California, San Francisco (1)
United States (5) · Taiwan (3) · Denmark (2) · Finland (2) · Brazil (1) · China (1) · France (1) · Japan (1) · Russia (1) · Spain (1)
Jen-Eing Jeng, M.D. (2) · Christian P Fischer, MD (1) · Corey L (1) · Douglas Fraker (1) · H. Richard Alexander, Jr. (1) · Jung-Fa Tsai, M.D., Ph.D. (1) · Kaplan L (1) · Katriina Peltola, MD, PhD (1) · MItsushige Sugimoto (1) · Tuomo Alanko (1) · Tuomo Alanko, MD, PhD (1)
PMID 18029463, PMID 23835341, PMID 39506856, PMID 40243391, PMID 41566775
U10CA076001 (1)