17 completed, 5 recruiting, 1 active not recruiting. 3 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Not applicable | 1 | Completed 1 |
Follow Situs Inversus: new trials by email Literature Review of Situs Inversus trials Research Report on Situs Inversus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bronchi Dilation in Polynesian Patients: Monocentric Retrospective Study Polynesian Bronchiectasis | Recruiting | Centre Hospitalier Intercommunal Creteil | 500 | 2025-06-01 | 2026-06-15 | |
| Study of Inhaled RCT1100 in Adults With PCD Caused by Pathogenic Mutations in the DNAI1 Gene to Measure Mucociliary Clearance RCT1100 - Primary Ciliary Dyskinesia (PCD) | Phase 1 | Completed | ReCode Therapeutics | 14 | 2024-10-22 | 2026-04-30 |
| A Study to Assess the Safety, Tolerability, Ciliary Rescue, and Pharmacodynamics of RCT1100 in Adults With PCD RCT1100 - Primary Ciliary Dyskinesia | Phase 1 | Completed | ReCode Therapeutics | 7 | 2024-09-20 | 2025-10-08 |
| A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults Spirometry, Multiple Breath Washout (MBW), Mucociliary Clearance (MCC) - Primary Ciliary Dyskinesia | Completed | ReCode Therapeutics | 31 | 2023-03-08 | 2026-05-04 | |
| Study Evaluating the Safety and Tolerability of RCT1100 in Healthy and PCD Subjects RCT1100 - Primary Ciliary Dyskinesia | Phase 1 | Completed | ReCode Therapeutics | 9 | 2023-02-18 | 2025-04-29 |
| Longitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary Dyskinesia Primary Ciliary Dyskinesia, Kartagener Syndrome | Completed | University of North Carolina, Chapel Hill | 105 | 2022-03-29 | 2025-12-10 | |
| Characterizing the Upper Airway Manifestations in Primary Ciliary Dyskinesia and Primary Immunodeficiencies Primary Ciliary Dyskinesia, Kartagener Syndrome | Completed | University of North Carolina, Chapel Hill | 159 | 2021-06-09 | 2025-08-21 | |
| Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults Genetic Testing for PCD or PID, Unaffected Family Member Genetic Testing - Primary Ciliary Dyskinesia, Primary Immune Deficiency | Completed | University of North Carolina, Chapel Hill | 436 | 2020-12-01 | 2025-08-21 | |
| The Ear-Nose-Throat (ENT) Prospective International Cohort of PCD Patients (EPIC-PCD) Primary Ciliary Dyskinesia, Kartagener Syndrome | Recruiting | University of Bern | 1000 | 2020-03-02 | 2025-12-02 | |
| Physical Fitness, Exercise Capacity and Activities of Daily Living in Primary Ciliary Dyskinesia: a Retrospective Study Data Collection - Primary Ciliary Dyskinesia, Kartagener Syndrome | Completed | Hacettepe University | 48 | 2020-01-21 | 2024-10-02 | |
| Effect of Game Based Approach on Oxygenation, Functional Capacity and Quality of Life in Primary Ciliary Dyskinesia Home based therapy, Game and home based therapy - Primary Ciliary Dyskinesia, Kartagener Syndrome | Not applicable | Completed | Hacettepe University | 32 | 2019-05-20 | 2021-08-24 |
| Genetics of Primary Ciliary Dyskinesia Primary Ciliary Dyskinesia, Kartagener Syndrome | Completed | University of North Carolina, Chapel Hill | 320 | 2015-02-01 | 2022-08-10 | |
| Determination of Normal Values of Nasal Nitric Oxide in Adults Normal Values of Nasal Nitric Oxide in Healthy Adults | Completed | Centre Hospitalier Universitaire Vaudois | 200 | 2014-02-01 | 2015-07-28 | |
| International Primary Ciliary Dyskinesia Cohort Primary Ciliary Dyskinesia, Kartagener Syndrome | Active not recruiting | University of Bern | 3400 | 2013-01-01 | 2025-11-25 | |
| Swiss Primary Ciliary Dyskinesia Registry Primary Ciliary Dyskinesia, Kartagener Syndrome | Recruiting | University of Bern | 800 | 2013-01-01 | 2025-11-25 | |
| Diagnosis of Primary Ciliary Dyskinesia Blood sample - Primary Ciliary Dyskinesia, Kartagener Syndrome | Completed | Assistance Publique - Hôpitaux de Paris | 125 | 2010-01-01 | 2013-08-07 | |
| Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Heterotaxy Syndrome, Congenital Heart Defects | Recruiting | Indiana University | 2000 | 2009-07-01 | 2026-06-22 | |
| Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Kartagener Syndrome | Completed | University of North Carolina, Chapel Hill | 48 | 2008-07-01 | 2019-10-07 | |
| Dyskinesia, Heterotaxy and Congenital Heart Disease Ciliary Dyskinesia, Primary, Kartagener Syndrome | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 3 | 2008-01-25 | 2017-07-02 | |
| Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Primary Ciliary Dyskinesia | Completed | University of North Carolina, Chapel Hill | 150 | 2006-08-01 | 2019-10-07 |
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Kartagener Syndrome (21) · Ciliary Motility Disorders (20) · Heart Defects, Congenital (3) · Primary Immunodeficiency Diseases (2) · Abnormalities, Multiple (1) · Cardiovascular Abnormalities (1) · Cardiovascular Diseases (1) · Congenital Abnormalities (1) · Cystic Fibrosis (1) · Dextrocardia (1) · Heart Diseases (1) · Heterotaxy Syndrome (1) · Holoprosencephaly (1) · Pseudohypoaldosteronism (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (23) · Abnormalities, Multiple (22) · Cardiovascular Abnormalities (22) · Cardiovascular Diseases (22) · Congenital Abnormalities (22) · Genetic Diseases, Inborn (22) · Heart Diseases (22) · Bronchial Diseases (21) · Bronchiectasis (21) · Ciliopathies (21) · Dextrocardia (21) · Otorhinolaryngologic Diseases (21) · Respiratory System Abnormalities (21) · Respiratory Tract Diseases (21) · Heart Defects, Congenital (20)
Apoptosis (1) · Blood Specimen Collection (1) · Data Collection (1) · Genetic Testing (1) · Mucociliary Clearance (1) · Spirometry (1)
University of North Carolina, Chapel Hill (8) · ReCode Therapeutics (4) · University of Bern (3) · Hacettepe University (2) · Assistance Publique - Hôpitaux de Paris (1) · Centre Hospitalier Intercommunal Creteil (1) · Centre Hospitalier Universitaire Vaudois (1) · Indiana University (1) · National Human Genome Research Institute (NHGRI) (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1)
United States (14) · Canada (7) · Switzerland (4) · Turkey (Türkiye) (2) · United Kingdom (2) · Australia (1) · Denmark (1) · France (1) · French Polynesia (1) · Germany (1) · New Zealand (1)
John Matthews, MBBS, MCRP, PhD (3) · Claudia E Kuehni, Prof (2) · Deniz Inal Ince, Prof. Dr. (2) · Stephanie Davis, MD (2) · Hayriye Ugur Ozcelik, Prof. Dr. (1) · Hazal Sonbahar Ulu, MSc (1) · Hazal Sonbahar Ulu, MSc, PT (1) · Heymut Omran, MD (1) · Kenneth Olivier, MD, MPH (1) · Kenneth R. Olivier, MD, MPH (1) · Kim G Nielsen, Dr Med Sci (1) · Margaret Rosenfeld, MD (1) · Margaret Rosenfeld, MD, MPH (1) · Margaret W Leigh, MD (1) · Margaret W. Leigh, MD (1)
PMID 23477994, PMID 38072392, PMID 16627867, PMID 16858015, PMID 17059358, PMID 17449765, PMID 17515466, PMID 20350728, PMID 21270641, PMID 21514598, PMID 21926392, PMID 21926394, PMID 21926395, PMID 21926396, PMID 22177992, PMID 22184204, PMID 22276227, PMID 22328589, PMID 22499950, PMID 23040496, PMID 23798057, PMID 23849778, PMID 23872636, PMID 23891469, PMID 23957500, PMID 24024753, PMID 24055112, PMID 24094744, PMID 24577564, PMID 27070726, PMID 28052956, PMID 29269581, PMID 30049738, PMID 30691261, PMID 31273043, PMID 31533829, PMID 32899853, PMID 34635525, PMID 35301251, PMID 35415187, PMID 35536410, PMID 36041191
U54HL096458 (5), R01HL071798 (1), U54RR019480 (1)