3 enrolling by invitation, 1 completed, 1 not yet recruiting. 1 Early Phase 1, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 1 | Not yet recruiting 1 |
| Phase 1 | 1 | Enrolling by invitation 1 |
| Phase 2 | 1 | Enrolling by invitation 1 |
Follow Severe Combined Immunodeficiency (SCID): new trials by email Literature Review of Severe Combined Immunodeficiency (SCID) trials Research Report on Severe Combined Immunodeficiency (SCID)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 25BT056: Basket Study of Viral Cytotoxic T Lymphocytes Virus-Specific Cytotoxic T Lymphocytes (vCTLs) - EBV Viremia, CMV Viremia | Early Phase 1 | Not yet recruiting | Children's Hospital of Philadelphia | 35 | 2026-11-01 | 2026-10-22 |
| Study of Populations at Risk of Developing Chronic Hepatitis Linked to Chronic Enteric Virus Infection in Patients With Primary Immunodeficiency and Secondary Humoral Deficiency Plasma, urine and stool collection - Humoral Primary Immunodeficiencies (PIDs), Secondary Form of Humoral Immunodeficiencies | Completed | Assistance Publique - Hôpitaux de Paris | 200 | 2024-10-10 | 2026-09-24 | |
| An Observational LTFU Study for Patients Previously Treated With Autologous ex Vivo Gene Therapy for ADA-SCID autologous ex vivo gene therapy products based on the EFS LV encoding for the human adenosine deaminase (ADA) gene (EFS-ADA LV) - Adenosine Deaminase Deficiency, Severe Combined Immunodeficiency (SCID) | Enrolling by invitation | University of California, Los Angeles | 70 | 2019-09-26 | 2025-12-18 | |
| Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases CD3/CD19 negative allogeneic hematopoietic stem cells - Severe Combined Immunodeficiency (SCID), Immunodeficiency With Predominant T-cell Defect, Unspecified | Phase 1 / Phase 2 | Enrolling by invitation | Paul Szabolcs | 16 | 2013-06-20 | 2025-12-15 |
| Natural History Study of SCID Disorders Severe Combined Immunodeficiency (SCID), Leaky SCID | Enrolling by invitation | National Institute of Allergy and Infectious Diseases (NIAID) | 690 | 2010-09-02 | 2020-11-10 |
Severe Combined Immunodeficiency (5) · Severe combined immunodeficiency due to adenosine deaminase deficiency (2) · Adenoviridae Infections (1) · Common Variable Immunodeficiency (1) · Epstein-Barr Virus Infections (1) · Granulomatous Disease, Chronic (1) · Inflammatory Bowel Diseases (1) · Job Syndrome (1) · Neutropenia, severe chronic (1) · Primary Immunodeficiency Diseases (1) · Reticular dysgenesis (1) · Viremia (1) · Virus Diseases (1) · Wiskott-Aldrich Syndrome (1) · X-Linked Combined Immunodeficiency Diseases (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · DNA Repair-Deficiency Disorders (5) · Genetic Diseases, Inborn (5) · Immune System Diseases (5) · Immunologic Deficiency Syndromes (5) · Infant, Newborn, Diseases (5) · Metabolic Diseases (5) · Nutritional and Metabolic Diseases (5) · Primary Immunodeficiency Diseases (4) · Genetic Diseases, X-Linked (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Blood Coagulation Disorders (1) · Blood Coagulation Disorders, Inherited (1) · Chronic Disease (1)
Assistance Publique - Hôpitaux de Paris (1) · Children's Hospital of Philadelphia (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Paul Szabolcs (1) · University of California, Los Angeles (1)
United States (3) · Canada (1) · France (1) · United Kingdom (1)
Caitlin Elgarten, MD, MSCE (1) · Christopher C. Dvorak, MD (1) · Donald B. Kohn, M.D. (1) · Morton J. Cowan, MD (1) · Paul Szabolcs, MD (1) · Victor Michel, MD (1)
PMID 20004776, PMID 23818196, PMID 24139498, PMID 24290292, PMID 24331379, PMID 25075835, PMID 27262745, PMID 29021228, PMID 30193840, PMID 33006109, PMID 35671392, PMID 41092330, PMID 41289158