17 completed. 17 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 17 |
| Phase 2 | 5 | Completed 5 |
Follow Refractory Anemia With Excess Blasts: new trials by email Literature Review of Refractory Anemia With Excess Blasts trials Research Report on Refractory Anemia With Excess Blasts
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine - Chronic Myelomonocytic Leukemia, Previously Treated Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 16 | 2012-01-01 | 2019-12-10 |
| Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome flow cytometry, DNA methylation analysis, cytogenetic analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 25 | 2010-07-01 | 2019-03-04 |
| Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome Pretargeted Radioimmunotherapy, Cyclosporine, Mycophenolate Mofetil - Chronic Myelomonocytic Leukemia, Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable | Phase 1 | Completed | Fred Hutchinson Cancer Center | 17 | 2010-04-21 | 2017-08-30 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Flavopiridol and Vorinostat in Treating Patients With Relapsed or Refractory Acute Leukemia or Chronic Myelogenous Leukemia or Refractory Anemia alvocidib, vorinostat - Blastic Phase Chronic Myelogenous Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2006-01-01 | 2013-04-02 |
| Lenalidomide in Treating Young Patients With Relapsed or Refractory Solid Tumors or Myelodysplastic Syndromes lenalidomide - Childhood Myelodysplastic Syndromes, de Novo Myelodysplastic Syndromes | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2005-03-01 | 2014-06-11 |
| SB-715992 in Treating Patients With Acute Leukemia, Chronic Myelogenous Leukemia, or Advanced Myelodysplastic Syndromes ispinesib, laboratory biomarker analysis, pharmacological study - Acute Undifferentiated Leukemia, Adult Acute Megakaryoblastic Leukemia (M7) | Phase 1 | Completed | National Cancer Institute (NCI) | 40 | 2004-12-01 | 2013-01-11 |
| XK469R in Treating Patients With Refractory Hematologic Cancer R(+)XK469, pharmacological study, laboratory biomarker analysis - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 60 | 2004-10-01 | 2013-02-08 |
| Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia cytarabine, idarubicin, tipifarnib - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 95 | 2004-09-01 | 2014-05-26 |
| Rebeccamycin Analog in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia becatecarin, laboratory biomarker analysis - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 1 | Completed | National Cancer Institute (NCI) | 40 | 2004-05-01 | 2013-01-23 |
| Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation therapeutic allogeneic lymphocytes, aldesleukin, peripheral blood stem cell transplantation - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2002-09-01 | 2017-03-29 |
| Tipifarnib in Treating Patients With Myelodysplastic Syndromes tipifarnib, laboratory biomarker analysis, pharmacological study - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 | Completed | National Cancer Institute (NCI) | 65 | 2002-06-01 | 2013-12-16 |
| BMS-214662 in Treating Patients With Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myeloid Leukemia BMS-214662, pharmacological study, laboratory biomarker analysis - Adult Acute Promyelocytic Leukemia (M3), Blastic Phase Chronic Myelogenous Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2000-04-01 | 2013-01-23 |
| Liposomal Daunorubicin and SU5416 in Treating Patients With Hematologic Cancer That Has Not Responded to Initial Therapy liposomal daunorubicin citrate, semaxanib, laboratory biomarker analysis - Chronic Myelomonocytic Leukemia, Previously Treated Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 37 | 2000-03-01 | 2013-01-23 |
| PS-341 in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia in Blast Phase, or Myelodysplastic Syndrome bortezomib - Adult Acute Promyelocytic Leukemia (M3), Blastic Phase Chronic Myelogenous Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2000-02-01 | 2013-01-23 |
| Vaccine Therapy Plus Immune Adjuvant in Treating Patients With Chronic Myeloid Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome PR1 leukemia peptide vaccine, Montanide ISA 51 VG, sargramostim - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 69 | 1999-12-01 | 2013-01-07 |
| Radiolabeled Monoclonal Antibody Therapy, Fludarabine Phosphate, and Low-Dose Total-Body Irradiation Followed by Donor Stem Cell Transplant and Immunosuppression Therapy in Treating Older Patients With Advanced Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes iodine I 131 monoclonal antibody BC8, total-body irradiation, allogeneic hematopoietic stem cell transplantation - Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 1 | Completed | Fred Hutchinson Cancer Center | 79 | 1999-07-27 | 2019-11-13 |
Anemia, Refractory, with Excess of Blasts (17) · Leukemia, Myeloid, Acute (12) · Leukemia, Myelomonocytic, Chronic (10) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (10) · Congenital Abnormalities (7) · Blast Crisis (6) · Anemia, Refractory (4) · Leukemia, Erythroblastic, Acute (3) · Leukemia, Megakaryoblastic, Acute (3) · Leukemia, Monocytic, Acute (3) · Leukemia, Myelomonocytic, Acute (3) · Leukemia, Promyelocytic, Acute (3) · Leukemia, Basophilic, Acute (2) · Leukemia, Eosinophilic, Acute (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2)
Anemia (17) · Bone Marrow Diseases (17) · Hematologic Diseases (17) · Hemic and Lymphatic Diseases (17) · Chronic Disease (16) · Disease Attributes (16) · Leukemia (16) · Leukemia, Myeloid (16) · Myelodysplastic Syndromes (16) · Neoplasms (16) · Neoplasms by Histologic Type (16) · Pathologic Processes (16) · Pathological Conditions, Signs and Symptoms (16) · Anemia, Refractory (13) · Immune System Diseases (10)
Cyclosporine (4) · Mycophenolic Acid (4) · Peripheral Blood Stem Cell Transplantation (4) · fludarabine phosphate (4) · Whole-Body Irradiation (3) · Cyclosporins (2) · Cytogenetic Analysis (2) · Flow Cytometry (2) · Gene Expression Profiling (2) · Immunologic Techniques (2) · tipifarnib (2) · 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (1) · Amplified Fragment Length Polymorphism Analysis (1) · Biopsy (1) · Bortezomib (1)
National Cancer Institute (NCI) (11) · Fred Hutchinson Cancer Center (5) · Case Comprehensive Cancer Center (1)
United States (17)
Francis Giles (3) · Jorge Cortes (3) · Brenda Sandmaier (2) · Brenda Cooper (1) · Brenda Cooper, MD (1) · Colleen Delaney (1) · Johnnie Orozco (1) · Merav Bar (1) · Muzaffar Qazilbash (1) · Razelle Kurzrock (1) · Stacey Berg (1) · Steven Grant (1) · Yogen Saunthararajah (1)
PMID 19786617, PMID 21149673, PMID 25621498, PMID 31582553
U01CA062461 (4), P01CA044991 (3), P30CA015704 (3), N01CM62202 (1), P01CA018029 (1), R21CA115260 (1), R24HL074445 (1), R43HL106868 (1), RC2HL101844 (1), U01CA062490 (1), U01CA062502 (1), U01CA062505 (1), U01CA097452 (1)