22 completed, 1 active not recruiting, 1 recruiting, 1 terminated. 18 Phase 2, 9 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 15, Active not recruiting 1, Recruiting 1, Terminated 1 |
| Phase 1 | 9 | Completed 8, Active not recruiting 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Refractory Anemia: new trials by email Literature Review of Refractory Anemia trials Research Report on Refractory Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cord Blood Transplant With Dilanubicel for the Treatment of HIV Positive Hematologic Cancers Fludarabine, Cyclophosphamide, Thiotepa - Acute Erythroid Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 1 | 2022-10-06 | 2025-01-01 |
| Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders HSCT with TBI Regimen, HSCT with Non-TBI Regimen - Acute Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 300 | 2018-03-30 | 2026-06-25 |
| DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, Decitabine, and Nivolumab in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Decitabine, Laboratory Biomarker Analysis - Acute Myeloid Leukemia, Blasts 30 Percent or Less of Bone Marrow Nucleated Cells | Phase 1 | Completed | Roswell Park Cancer Institute | 8 | 2018-03-27 | 2026-02-27 |
| Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Fludarabine, Total-Body Irradiation, T Cell-Depleted Donor Lymphocyte Infusion - Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 35 | 2015-11-13 | 2025-04-24 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Wake Forest University Health Sciences | 16 | 2011-01-01 | 2018-09-07 |
| Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies umbilical cord blood transplantation, fludarabine phosphate, cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 15 | 2010-08-01 | 2019-03-05 |
| Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome flow cytometry, DNA methylation analysis, cytogenetic analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 25 | 2010-07-01 | 2019-03-04 |
| Pilot of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor HCT Abatacept - AML, ALL | Phase 2 | Completed | Boston Children's Hospital | 11 | 2009-11-01 | 2019-11-21 |
| Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia laboratory biomarker analysis - Childhood Acute Erythroleukemia (M6), Childhood Acute Megakaryocytic Leukemia (M7) | Completed | Children's Oncology Group | 20 | 2009-05-01 | 2016-05-17 | |
| MS-275 and GM-CSF in Treating Patients With Myelodysplastic Syndrome and/or Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphocytic Leukemia entinostat, sargramostim - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7) | Phase 2 | Completed | National Cancer Institute (NCI) | 24 | 2007-04-01 | 2017-07-18 |
| Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia Azacitidine, Laboratory Biomarker Analysis, Pharmacological Study - Acute Erythroid Leukemia, Acute Megakaryoblastic Leukemia | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 135 | 2006-11-22 | 2026-08-07 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Bowel Preparation and Prokinetics in Capsule Endoscopy Senna, Citramag powder, Metoclopramide - Small Bowel Disease, Gastrointestinal Hemorrhage | Phase 3 | Unknown | London North West Healthcare NHS Trust | 150 | 2006-01-01 | 2007-09-24 |
| Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders Cyclosporine, Fludarabine Phosphate, Laboratory Biomarker Analysis - Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, Chronic Myelomonocytic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 77 | 2006-01-01 | 2020-01-31 |
| Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease Cyclophosphamide, Cyclosporine, Double-Unit Umbilical Cord Blood Transplantation - Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 135 | 2005-11-18 | 2025-03-07 |
| Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia filgrastim, busulfan, cyclosporine - Leukemia, Myelodysplastic Syndromes | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 34 | 2005-11-01 | 2025-08-26 |
| Myeloablative Umbilical Cord Blood Transplantation in Hematological Diseases filgrastim, cyclophosphamide, cyclosporine - Acute Myeloid Leukemia, Acute Lymphocytic Leukemia | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 213 | 2005-07-28 | 2020-09-10 |
| Lenalidomide in Treating Young Patients With Relapsed or Refractory Solid Tumors or Myelodysplastic Syndromes lenalidomide - Childhood Myelodysplastic Syndromes, de Novo Myelodysplastic Syndromes | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2005-03-01 | 2014-06-11 |
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Anemia, Refractory (26) · Anemia, Refractory, with Excess of Blasts (17) · Leukemia, Myelomonocytic, Chronic (16) · Leukemia, Myeloid, Acute (14) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (11) · Leukemia, Lymphocytic, Chronic, B-Cell (9) · Lymphoma, Non-Hodgkin (9) · Myelodysplastic Syndromes (9) · Congenital Abnormalities (8) · Lymphoma, B-Cell, Marginal Zone (8) · Lymphoma, Follicular (8) · Multiple Myeloma (8) · Myeloproliferative Disorders (8) · Burkitt Lymphoma (7) · Lymphoma, Mantle-Cell (7)
Anemia (26) · Bone Marrow Diseases (26) · Hematologic Diseases (26) · Hemic and Lymphatic Diseases (26) · Neoplasms by Histologic Type (24) · Pathologic Processes (23) · Pathological Conditions, Signs and Symptoms (23) · Chronic Disease (22) · Disease Attributes (22) · Leukemia, Myeloid (22) · Neoplasms (22) · Leukemia (21) · Myelodysplastic Syndromes (17) · Myelodysplastic-Myeloproliferative Diseases (17) · Immune System Diseases (12)
fludarabine phosphate (11) · Mycophenolic Acid (10) · Cyclosporine (9) · Whole-Body Irradiation (9) · Cyclophosphamide (8) · Cord Blood Stem Cell Transplantation (5) · Peripheral Blood Stem Cell Transplantation (5) · fludarabine (4) · Busulfan (3) · Cyclosporins (3) · Filgrastim (3) · Granulocyte Colony-Stimulating Factor (3) · Tacrolimus (3) · Transplantation (3) · Decitabine (2)
National Cancer Institute (NCI) (8) · Fred Hutchinson Cancer Center (6) · Masonic Cancer Center, University of Minnesota (3) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2) · Boston Children's Hospital (1) · Case Comprehensive Cancer Center (1) · Children's Oncology Group (1) · London North West Healthcare NHS Trust (1) · Nohla Therapeutics, Inc. (1) · Roswell Park Cancer Institute (1) · Wake Forest University Health Sciences (1)
United States (25) · Germany (2) · Italy (2) · United Kingdom (1)
Brenda Sandmaier (3) · B. Smith (2) · Colleen Delaney (2) · Usama Gergis, MD (2) · Alvaro Moreno Aspitia (1) · Ann E. Dahlberg (1) · Beverly Lange (1) · Brenda Cooper, MD (1) · Christen Ebens, MD (1) · Christopher Fraser, MB BCH, MD, FRCP (1) · Claudio G. Brunstein, MD, PhD (1) · Elizabeth Griffiths (1) · Filippo Milano (1) · Leslie Kean, MD, PhD (1) · Lewis R Silverman (1)
PMID 32499241, PMID 18997171, PMID 19304957, PMID 19706886, PMID 20056794, PMID 20413658, PMID 21149673, PMID 24047754, PMID 25621498, PMID 25852054, PMID 30630975, PMID 35445027, PMID 36815378, PMID 38295280, PMID 40809194, PMID 42085603
P30CA015704 (4), P01CA018029 (3), RC2HL101844 (2), N01CM17103 (1), N01CM62204 (1), P01CA015396 (1), P30CA013330 (1), P30CA046592 (1), R24HL074445 (1), R34HL142322 (1), R43HL106868 (1), U01CA062461 (1), U01CA070095 (1), U01CA097452 (1), U10CA025224 (1)