69 completed, 16 terminated, 9 recruiting, 9 unknown. 73 Phase 2, 30 Phase 1, 17 Not applicable, 6 Phase 3, 1 Early Phase 1.
Follow Recurrent Prostate Cancer: new trials by email Literature Review of Recurrent Prostate Cancer trials Research Report on Recurrent Prostate Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prostate Specific Membrane Antigen (PSMA) Imaging for Detection of Residual and Metastatic Prostate Cancer Bicalutamide, Prostate-specific membrane antigen Positron Emission Tomography-Computed Tomography, 18F-rhPSMA-7.3 - Prostate Cancer, Recurrent Prostate Cancer | Phase 2 | Not yet recruiting | Washington University School of Medicine | 20 | 2026-10-31 | 2026-09-11 |
| IL-15 Superagonist With or Without Vaccine in Biochemically Recurrent Prostate Cancer After Previous Stereotactic Body Radiation Therapy N-803, ETBX-71 Vaccine, 18F-DCFPyL - Recurrent Prostate Cancer, Prostate Cancer | Phase 2 | Recruiting | National Cancer Institute (NCI) | 65 | 2026-10-01 | 2026-10-06 |
| Alpha Radiation Emitters Device (DaRT) for the Treatment of Locally Recurrent Prostate Cancer Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT) - Prostate Cancer, Recurrent Prostate Cancer | Not applicable | Not yet recruiting | Alpha Tau Medical LTD. | 12 | 2026-05-01 | 2026-04-06 |
| Terbinafine for Biochemically Recurrent Prostate Cancer (TerbinaPro) Terbinafine - Recurrent Prostate Cancer | Phase 2 | Recruiting | Swiss Cancer Institute | 42 | 2026-04-24 | 2026-07-16 |
| Trial of pTVG-HP+Nivo+Targeted Ablation of Resistant Lesions in Non-Castrate RecurrentOMPC pTVG-HP DNA vaccine, Anti-PD-1 monoclonal antibody - Prostate Cancer Patients, Non-castrate Prostate Cancer | Phase 1 | Recruiting | University of Wisconsin, Madison | 14 | 2026-03-03 | 2026-03-11 |
| Determining Patterns In Trial Experiences of Recurrent Prostate Cancer Patients Recurrent Prostate Cancer | Not yet recruiting | Power Life Sciences Inc. | 500 | 2024-10-01 | 2023-10-06 | |
| Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial Abiraterone, Apalutamide, Biospecimen Collection - Recurrent Castration-Sensitive Prostate Carcinoma, Recurrent Prostate Cancer | Phase 2 | Recruiting | Mayo Clinic | 532 | 2024-06-03 | 2026-07-20 |
| Enzalutamide and PDS01ADC in PET Positive Recurrent Prostate Cancer (pprPC) Without Testosterone Lowering Therapy Enzalutamide, PDS01ADC - Prostate Cancer, Recurrent Prostate Cancer | Phase 2 | Recruiting | National Cancer Institute (NCI) | 65 | 2024-04-22 | 2026-10-16 |
| Trial of Ultrahypofractionated Focal Salvage Radiotherapy for Isolated Prostate Bed Recurrence After Radical Prostatectomy Ultrahypofractionated salvage radiotherapy to a local recurrence after radical prostatectomy, Androgen deprivation therapy - Recurrent Prostate Cancer | Not applicable | Active not recruiting | Insel Gruppe AG, University Hospital Bern | 36 | 2023-03-29 | 2025-12-31 |
| SCAP vs HIFU for Recurrent Prostate Cancer After Radiation Therapy Local treatment of the prostate (SCAP or HIFU) - Cryotherapy, High Intensity Focused Ultrasounds | Unknown | University Hospital Virgen de las Nieves | 50 | 2021-10-01 | 2021-09-16 | |
| Tumor Microenvironment Analysis of Prostate Cancer Metastasis Biopsy - Recurrent Prostate Cancer | Recruiting | Columbia University | 16 | 2021-09-15 | 2026-06-05 | |
| Study of ADXS-504 Immunotherapy for Recurrent Prostate Cancer ADXS-504 - Recurrent Prostate Cancer | Phase 1 | Completed | Mark Stein | 8 | 2021-08-12 | 2026-09-25 |
| Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer PET-directed Local Therapy using Surgery, PET-directed Local Therapy using Radiation, Salvage Local Therapy for locally recurrent disease - Prostate Cancer, Oligometastasis | Phase 2 / Phase 3 | Active not recruiting | VA Office of Research and Development | 378 | 2021-07-01 | 2026-10-19 |
| Salvage Cryotherapy for Recurrent Prostate Cancer After Radiation Therapy Salvage cryoablation of the prostate (SCAP) - Prostate Cancer, Cryotherapy | Not applicable | Unknown | Ignacio Puche Sanz | 100 | 2021-05-01 | 2021-05-18 |
| Safety and Efficacy of [18F]PSMA-1007 Injection in Suspected Persistent or Recurrent Prostate Cancer. [18F] PSMA-1007 Injection - Prostate Cancer Recurrent, Recurrent Prostate Cancer | Phase 3 | Completed | Centre for Probe Development and Commercialization | 100 | 2020-12-21 | 2024-02-07 |
| Nivolumab in Biochemically Recurrent dMMR Prostate Cancer Nivolumab - Prostate Cancer, Recurrent Prostate Cancer | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 8 | 2020-01-13 | 2026-05-15 |
| PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men w/ High Decipher Test Scores F-DCFPyL Injection, PSMA PET - Prostate Cancer, Recurrent Prostate Cancer | Phase 2 / Phase 3 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 60 | 2019-12-18 | 2026-03-02 |
| Impact of Atorvastatin on Prostate Cancer Progression During ADT Atorvastatin 80mg, Placebo oral capsule - Metastatic Prostate Cancer, Recurrent Prostate Cancer | Phase 3 | Unknown | Tampere University Hospital | 400 | 2019-08-15 | 2022-10-21 |
| Effects of Muscadine Grape Extract in Men With Prostate Cancer on Androgen Deprivation Therapy MGE, Placebo, ADT - Recurrent Prostate Cancer | Phase 2 | Completed | Wake Forest University Health Sciences | 106 | 2019-01-29 | 2026-03-31 |
| PSMA-PET Registry for Recurrent Prostate Cancer [18F]-DCFPyL or [18F]PSMA-1007 PET/ CT scan (PSMA PET) - Recurrent Prostate Cancer | Not applicable | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 9684 | 2018-09-27 | 2026-07-17 |
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Prostatic Neoplasms (118) · Breast Neoplasms (7) · Carcinoma, Non-Small-Cell Lung (5) · Carcinoma, Ovarian Epithelial (5) · Colonic Neoplasms (5) · Salivary Gland Neoplasms (5) · Uterine Cervical Neoplasms (5) · Breast Neoplasms, Male (4) · Carcinoma, Renal Cell (4) · Neoplasms (4) · Pancreatic Neoplasms (4) · Rectal Neoplasms (4) · Squamous Cell Carcinoma of Head and Neck (4) · Stomach Neoplasms (4) · Anus Neoplasms (3)
Genital Diseases (118) · Male Urogenital Diseases (118) · Urogenital Diseases (118) · Genital Diseases, Male (117) · Genital Neoplasms, Male (117) · Neoplasms by Site (117) · Prostatic Diseases (117) · Urogenital Neoplasms (117) · Neoplasms (114) · Breast Diseases (7) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Neoplasms by Histologic Type (7) · Pathological Conditions, Signs and Symptoms (7) · Skin Diseases (7)
Prednisone (11) · Leuprolide (9) · Docetaxel (8) · Goserelin (8) · enzalutamide (8) · Magnetic Resonance Spectroscopy (7) · Radiosurgery (6) · bicalutamide (6) · Abiraterone Acetate (5) · abiraterone (5) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (4) · Androgen Antagonists (3) · Bevacizumab (3) · Dasatinib (3) · Flutamide (3)
National Cancer Institute (NCI) (38) · University of Southern California (8) · Barbara Ann Karmanos Cancer Institute (5) · Case Comprehensive Cancer Center (3) · City of Hope Medical Center (3) · OHSU Knight Cancer Institute (3) · University of Colorado, Denver (3) · Jonsson Comprehensive Cancer Center (2) · Ohio State University Comprehensive Cancer Center (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2) · University of California, Irvine (2) · University of Chicago (2) · University of Nebraska (2) · University of Washington (2)
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Jacek Pinski (3) · Maha Hussain (3) · Ulka Vaishampayan (3) · Cy Stein, MD, PhD (2) · David Solit (2) · Elisabeth Heath (2) · Glenn Liu (2) · Mark N. Stein, MD (2) · Melissa L Abel, M.D. (2) · Primo Lara (2) · Robert Den, MD (2) · Russell Szmulewitz (2) · Tomasz Beer (2) · Abhishek Solanki, MD MS (1) · Agustin Garcia (1)
PMID 19349545, PMID 19483644, PMID 21049281, PMID 21106711, PMID 21784672, PMID 22006050, PMID 22689129, PMID 22932804, PMID 23652277, PMID 24048789, PMID 24099865, PMID 24788563, PMID 25199619, PMID 25819287, PMID 28178640, PMID 28692586, PMID 29476383, PMID 29684136, PMID 29685521, PMID 30682445, PMID 31838879, PMID 32349020, PMID 32850444, PMID 32994091, PMID 33270906, PMID 33496795, PMID 34028627, PMID 34604088, PMID 34616010, PMID 35076300, PMID 35487730, PMID 35608445, PMID 35938545, PMID 36996380, PMID 38296279, PMID 38992025, PMID 39663356, PMID 40610233, PMID 40932155, PMID 41346252, PMID 41802185, PMID 42117295
U10CA031946 (4), N01CM62201 (3), N01CM62206 (3), U10CA021115 (3), N01CM00071 (2), N01CM17101 (2), N01CM62202 (2), N01CM62209 (2), P30CA014089 (2), P30CA014599 (2), P30CA015704 (2), P30CA036727 (2), U01CA062491 (2), U01CA069856 (2), 2016 (1)