10 active not recruiting, 7 completed, 5 recruiting, 5 unknown. 14 Phase 2, 9 Phase 1, 4 Early Phase 1, 4 Not applicable, 1 Phase 3.
Follow Recurrent Glioma: new trials by email Literature Review of Recurrent Glioma trials Research Report on Recurrent Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors [F-18]MeFAMP PET - Healthy Volunteers, Recurrent Glioma | Early Phase 1 | Not yet recruiting | University of Alabama at Birmingham | 28 | 2027-04-01 | 2026-08-20 |
| VorAsidenib With Lomustine In Patients With rEcurrent IDH-mutaNT Glioma Harboring IDH1 and/or IDH2 Mutations Vorasidenib, Lomustine - Recurrent Glioma, IDH-mutant Gliomas | Phase 1 | Not yet recruiting | Megan Mantica | 36 | 2026-11-30 | 2026-10-22 |
| Sitagliptin in Recurrent/Progressive Grade 4 Glioma Sitagliptin, Bevacizumab - Glioma, Glioblastoma | Phase 1 | Recruiting | Kailin Yang, MD, PhD | 45 | 2026-06-11 | 2026-06-17 |
| Dietary Cysteine and Methionine Deprivation (CMD) in Glioma Patients Normal diet, Cysteine/methionine deprivation (CMD) diet for 2 days, Cysteine/methionine deprivation (CMD) diet for 4 days - Glioblastoma Multiforme, Recurrent Glioma | Not applicable | Withdrawn | UNC Lineberger Comprehensive Cancer Center | 2026-05-01 | 2026-04-28 | |
| A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial Chemotherapy, Computed Tomography, Internet-Based Intervention - Glioma, Recurrent Glioma | Not applicable | Recruiting | Mayo Clinic | 202 | 2025-09-12 | 2026-08-10 |
| PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial PRDR - Glioma, Glioma, Malignant | Not applicable | Recruiting | Baptist Health South Florida | 28 | 2025-04-30 | 2026-06-01 |
| Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment Biospecimen Collection, Erdafitinib, Magnetic Resonance Imaging - Recurrent Glioma, Recurrent WHO Grade 2 Glioma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 30 | 2024-01-04 | 2026-10-15 |
| Niraparib In Recurrent IDH 1/2 Gliomas Niraparib, Resection/Treatment with Niraparib - Low-grade Glioma, IDH2 Gene Mutation | Early Phase 1 | Active not recruiting | Massachusetts General Hospital | 16 | 2023-05-18 | 2026-07-24 |
| CARv3-TEAM-E T Cells in Glioblastoma CARv3-TEAM-E T cells - Glioblastoma, Malignant Glioma | Phase 1 | Recruiting | Marcela V. Maus, M.D.,Ph.D. | 21 | 2023-03-22 | 2026-07-14 |
| Low-dose Bevacizumab With HSRT vs BVZ Alone for GBM at First Recurrence Hypofractionated Stereotactic Radiotherapy, Bevacizumab - Glioma, Recurrent Glioma | Phase 2 | Unknown | Huashan Hospital | 42 | 2022-10-01 | 2022-11-10 |
| PARP Inhibition for Gliomas (PI-4G or π4g) Niraparib - Recurrent Glioblastoma, Recurrent Astrocytoma | Phase 2 | Terminated | University of Oklahoma | 15 | 2022-06-09 | 2025-05-23 |
| Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma Biospecimen Collection, Diagnostic Imaging, Magnetic Resonance Imaging - Glioma, Malignant Glioma | Early Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 36 | 2021-09-01 | 2026-10-20 |
| Personalized Vaccine for Patients With Recurrent Malignant Glioma personalized vaccine - Malignant Glioma, Recurrent Glioma | Phase 1 | Unknown | Xuanwu Hospital, Beijing | 10 | 2021-07-15 | 2021-06-29 |
| A Study of GNC-039, a Tetra-specific Antibody, in Participants With Relapsed/Refractory or Metastatic Solid Tumors GNC-039 - Recurrent Glioma, Solid Tumor | Phase 1 | Recruiting | Sichuan Baili Pharmaceutical Co., Ltd. | 60 | 2021-04-14 | 2026-08-27 |
| Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd Talazoparib - Recurrent Glioma, Recurrent Glioblastoma | Phase 2 | Completed | The University of Hong Kong | 33 | 2021-01-01 | 2025-06-11 |
| Role of Surgery in Treatment of Recurrent Brian Glioma:Prognostic Factors and Outcome Recurrent Glioma, Glioma, Malignant | Unknown | Assiut University | 25 | 2020-10-01 | 2020-09-24 | |
| Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO) Vorasidenib, Matching Placebo - Grade 2 Glioma, Residual Glioma | Phase 3 | Active not recruiting | Institut de Recherches Internationales Servier | 331 | 2020-01-05 | 2025-04-03 |
| A Study of PRT811 in Participants With Advanced Solid Tumors, CNS Lymphoma and Gliomas PRT811 - Advanced Solid Tumor, Recurrent Glioma | Phase 1 | Completed | Prelude Therapeutics Incorporated | 86 | 2019-11-06 | 2023-04-05 |
| Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases Best Practice, Ketoconazole - Anatomic Stage IV Breast Cancer AJCC v8, Astrocytoma | Early Phase 1 | Terminated | Wake Forest University Health Sciences | 15 | 2019-03-13 | 2026-07-31 |
| Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Glioblastoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 89 | 2019-01-30 | 2026-09-09 |
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Glioma (33) · Glioblastoma (8) · Ependymoma (7) · Hepatoblastoma (7) · Histiocytosis, Langerhans-Cell (7) · Lymphoma, Non-Hodgkin (7) · Medulloblastoma (7) · Neuroblastoma (7) · Neuroectodermal Tumors, Primitive, Peripheral (7) · Osteosarcoma (7) · Rhabdoid Tumor (7) · Rhabdomyosarcoma (7) · Sarcoma (7) · Wilms Tumor (7) · Central Nervous System Neoplasms (5)
Neoplasms (33) · Neoplasms by Histologic Type (33) · Neoplasms, Germ Cell and Embryonal (33) · Neoplasms, Glandular and Epithelial (33) · Neoplasms, Nerve Tissue (33) · Neoplasms, Neuroepithelial (33) · Neuroectodermal Tumors (33) · Neoplasms by Site (9) · Female Urogenital Diseases (8) · Female Urogenital Diseases and Pregnancy Complications (8) · Hemic and Lymphatic Diseases (8) · Immune System Diseases (8) · Immunoproliferative Disorders (8) · Kidney Diseases (8) · Kidney Neoplasms (8)
Magnetic Resonance Spectroscopy (8) · Specimen Handling (6) · X-Rays (5) · Bevacizumab (4) · Biopsy (4) · Nuclear Medicine Department, Hospital (3) · Phantoms, Imaging (3) · erdafitinib (3) · larotrectinib (3) · olaparib (3) · palbociclib (3) · ulixertinib (3) · LY3023414 (2) · Radiosurgery (2) · niraparib (2)
National Cancer Institute (NCI) (10) · Assiut University (1) · Baptist Health South Florida (1) · City of Hope Medical Center (1) · Huashan Hospital (1) · Institut de Recherches Internationales Servier (1) · Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS (1) · Jonsson Comprehensive Cancer Center (1) · Kailin Yang, MD, PhD (1) · Marcela V. Maus, M.D.,Ph.D. (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Megan Mantica (1) · Prelude Therapeutics Incorporated (1) · Sichuan Baili Pharmaceutical Co., Ltd. (1)
United States (26) · Puerto Rico (8) · China (4) · Canada (2) · Italy (2) · Australia (1) · Egypt (1) · France (1) · Germany (1) · Guam (1) · Hong Kong (1) · Israel (1) · Japan (1) · Netherlands (1) · Spain (1)
Adam Cohen, MD (1) · Ahmed AlGhriany, phD (1) · Ahmed AlShanawany, phD (1) · Aya Helali, MD, PhD (1) · Behnam Badie (1) · Benjamin M Ellingson (1) · Dominique Higgins, MD, PhD (1) · Donald W Parsons (1) · Donatella Arpa (1) · Isabel Arrillaga-Romany, MD, Phd (1) · James Battiste, MD (1) · Jonathan McConathy, MD, PhD (1) · Julia Glade-Bender (1) · Kailin Yang, MD, PhD (1) · Katherine A Janeway (1)
PMID 31401903, PMID 26586415, PMID 32463741, PMID 33048619, PMID 33591402, PMID 33859944, PMID 35133871, PMID 35138919, PMID 35353553, PMID 36351402, PMID 37053535, PMID 37191188, PMID 37272516, PMID 37322121, PMID 37934000, PMID 38477966, PMID 38591867, PMID 38815151, PMID 38935895, PMID 39298716, PMID 39666929, PMID 39693587, PMID 39913886, PMID 40675687, PMID 40865033, PMID 41066729, PMID 41166674, PMID 41175888, PMID 42686334
U10CA180886 (7), 2019 (1), P30CA012197 (1), P30CA033572 (1), U10CA180820 (1), U24CA196172 (1), UM1CA186644 (1), UM1CA186689 (1)