10 completed, 5 unknown, 2 terminated, 2 withdrawn. 8 Not applicable, 2 Phase 2, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 4, Unknown 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
Follow Raynaud Phenomenon: new trials by email Literature Review of Raynaud Phenomenon trials Research Report on Raynaud Phenomenon
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Diagnosis of SSc in the General Rheumatology Clinic - Pilot Observation - Nailfold capillaroscopy - Systemic Sclerosis, Raynaud Phenomenon | Completed | University of Manchester | 112 | 2023-11-22 | 2025-04-03 | |
| Phototherapy For Treatment Of Raynaud's Phenomenon Blue Light Therapy, Sham Light Therapy - Raynaud Disease, Raynaud Phenomenon | Not applicable | Withdrawn | University of Minnesota | 2022-08-01 | 2023-01-06 | |
| Rheopheresis for Raynaud's and Digital Ulcers in Systemic Sclerosis Rheopheresis treatment, Intravenous Infusion - Systemic Sclerosis, Raynaud Phenomenon | Not applicable | Unknown | Peter Korsten | 30 | 2022-02-28 | 2022-03-23 |
| Botulinum Toxin in Raynaud's Phenomenon Botulinum toxin - Raynaud Phenomenon | Phase 4 | Completed | Emory University | 24 | 2022-02-10 | 2026-07-29 |
| Dermoscopy in Primary Raynaud's Phenomenon Dermoscopy - Raynaud Phenomenon | Completed | Assistance Publique - Hôpitaux de Paris | 100 | 2021-01-01 | 2021-07-20 | |
| Nutritional Strategies to Increase Nitric Oxide Signaling in Raynaud's Phenomenon L-citrulline, Beetroot juice, L-citrulline placebo - Raynaud Phenomenon | Not applicable | Unknown | University Hospital, Grenoble | 30 | 2020-10-01 | 2021-05-14 |
| Apollo Device for Fatigue in Systemic Sclerosis Apollo - Systemic Sclerosis, Fatigue | Not applicable | Completed | Robyn T. Domsic, MD, MPH | 25 | 2020-07-07 | 2025-04-02 |
| Application for Monitoring and Evaluation of Raynaud's Phenomenon Smartphone application - Raynaud Phenomenon | Unknown | University Hospital, Grenoble | 120 | 2020-03-31 | 2023-12-06 | |
| Cold Challenge With C21 in RP C21, Placebo - Raynaud Phenomenon, Systemic Sclerosis | Phase 2 | Completed | Vicore Pharma AB | 20 | 2020-01-03 | 2023-05-18 |
| Localized Effects of PBM and Exogenous NO on CREST Patients Calcinosis Cutis & Raynaud Phenomenon INOMAX - CREST Syndrome, Calcinosis Cutis | Unknown | RoseLab Skin Optics Laboratory | 5 | 2019-06-20 | 2019-06-03 | |
| Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena. gammaCore Sapphire, Sham Device - Raynaud Phenomenon, Primary Raynaud Phenomenon | Not applicable | Terminated | University of Toledo Health Science Campus | 6 | 2019-04-30 | 2025-07-15 |
| Follow-up of SPTS in Patients With Raynaud's Phenomenon Single-port thoracoscopic sympathicotomy (patient care) - Raynaud Phenomenon | Unknown | University Medical Center Groningen | 50 | 2019-03-28 | 2019-07-10 | |
| Tadalafil-Delivra and Raynaud's Phenomenon Observation of treatment with Tadalafil-Delivra - Raynaud Phenomenon | Withdrawn | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2018-10-01 | 2018-09-20 | ||
| Effectiveness of Electric Stimulation Therapy in Raynaud's Phenomenon Electrotherapy with Galvanic Current, Control without Electric Stimulation Therapy - Raynaud Phenomenon, Raynaud Disease | Not applicable | Completed | Universidad de Granada | 60 | 2018-10-01 | 2020-11-09 |
| The Effect of Abobotulinum Toxin A on the Symptoms of Raynaud's Phenomenon AbobotulinumtoxinA, Saline solution - Raynaud Phenomenon | Phase 4 | Terminated | University of Central Florida | 3 | 2018-08-31 | 2021-06-30 |
| Beet the Cold: The Effect of Inorganic Nitrate Supplementation in Individuals With Raynaud's Phenomenon Concentrated beetroot juice - Raynaud Phenomenon | Not applicable | Completed | University of Portsmouth | 27 | 2017-07-01 | 2020-02-10 |
| Investigation of the Rewarming og the Fingers After Cooling and the Autonomic Nervous System in Raynaud's Phenomenon Examination of vibration perception threshold in fingertips, Ewing's tests, Tilt table test - Raynaud Disease, Raynaud Phenomenon | Not applicable | Completed | Herlev Hospital | 174 | 2017-01-01 | 2019-02-28 |
| Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis Sildenafil citrate, Placebo (Sugar pill) - Scleroderma, Systemic, Scleroderma, Diffuse | Phase 3 | Completed | Federal University of São Paulo | 41 | 2011-04-01 | 2016-12-05 |
| Efficacy Study of PDE-5 Inhibitor and Calcium Channel Inhibitor for the Treatment of Secondary Raynaud Phenomenon Udenafil or Amlodipine - Raynaud Phenomenon | Phase 2 / Phase 3 | Completed | Seoul National University Hospital | 29 | 2011-01-01 | 2012-12-11 |
Raynaud Disease (19) · Scleroderma, Systemic (5) · Scleroderma, Diffuse (3) · Pain (2) · CREST Syndrome (1) · Calcinosis Cutis (1) · Diabetes Mellitus (1) · Fatigue (1) · Glaucoma (1) · Hand-Arm Vibration Syndrome (1) · Parkinson Disease (1) · Scleroderma, Limited (1) · Signs and Symptoms (1) · digital ulcers (1)
Cardiovascular Diseases (19) · Embolism and Thrombosis (19) · Livedoid Vasculopathy (19) · Peripheral Vascular Diseases (19) · Skin Diseases (19) · Skin Diseases, Vascular (19) · Skin and Connective Tissue Diseases (19) · Thrombosis (19) · Vascular Diseases (19) · Connective Tissue Diseases (6) · Pathological Conditions, Signs and Symptoms (3) · Metabolic Diseases (2) · Neurologic Manifestations (2) · Nutritional and Metabolic Diseases (2) · Signs and Symptoms (2)
Amlodipine (1) · Blood Specimen Collection (1) · Botulinum Toxins (1) · Citrulline (1) · Control Groups (1) · Dermoscopy (1) · Electric Stimulation Therapy (1) · Endothelium-Dependent Relaxing Factors (1) · Infusions, Intravenous (1) · Long-Term Synaptic Depression (1) · Patient Care (1) · Phototherapy (1) · Saline Solution (1) · Sildenafil Citrate (1) · Sugars (1)
University Hospital, Grenoble (2) · Assistance Publique - Hôpitaux de Paris (1) · Emory University (1) · Federal University of São Paulo (1) · Herlev Hospital (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Peter Korsten (1) · Robyn T. Domsic, MD, MPH (1) · RoseLab Skin Optics Laboratory (1) · Seoul National University Hospital (1) · Universidad de Granada (1) · University Medical Center Groningen (1) · University of Central Florida (1) · University of Manchester (1) · University of Minnesota (1)
United States (5) · France (3) · United Kingdom (3) · Canada (2) · Brazil (1) · Denmark (1) · Germany (1) · Netherlands (1) · South Korea (1) · Spain (1)
Ariane E Herrick, MD, FRCP (1) · Ariane Herrick, MD (1) · Bashar Kahaleh, MD (1) · Douwe J Mulder, MD, PhD (1) · Eun Bong Lee, MD PhD (1) · Eun Young Lee, MD PhD (1) · Fernando V Andrigueti, MD (1) · Janet E Pope, MD PhD (1) · Jean-Luc Cracowski, MD (1) · Jerry Molitor, MD, PhD (1) · Jin Kyun Park, MD (1) · Lars T Jensen, DMSc (1) · Matthieu Roustit, PharmD, PhD (1) · Paul A Ghareeb, MD (1)
PMID 24352340, PMID 33804657, PMID 35492333, PMID 35894657, PMID 37929840, PMID 39617410
2019 (1)