30 completed, 18 unknown, 6 terminated, 5 recruiting. 62 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 62 | Completed 30, Unknown 18, Terminated 6, Recruiting 5, Active not recruiting 1, Enrolling by invitation 1, Withdrawn 1 |
Follow Precursor Cell Lymphoblastic Leukemia-Lymphoma: new trials by email Literature Review of Precursor Cell Lymphoblastic Leukemia-Lymphoma trials Research Report on Precursor Cell Lymphoblastic Leukemia-Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Levofloxacin Prophylaxis to Prevent First Febrile Neutropenia in Pediatric ALL During Induction Phase Levofloxacin, Placebo - Neutropenic Fever, Acute Lymphoblastic Leukemia | Phase 4 | Terminated | Gadjah Mada University | 49 | 2026-01-01 | 2026-10-01 |
| Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies Ceftazidime, Ciprofloxacin - Neutropenic Fever, Acute Lymphoblastic Leukemia | Phase 4 | Recruiting | Gadjah Mada University | 120 | 2025-06-01 | 2025-08-22 |
| Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma Dexamethasone, Vincristine, Daunorubicin - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 4 | Recruiting | St. Jude Children's Research Hospital | 850 | 2024-12-26 | 2026-07-14 |
| Antimicrobial Revision in Persistent Febrile Neutropenia Meropenem, Micafungin - Febrile Neutropenia | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2024-08-01 | 2024-09-19 | |
| Exploring the Minimum Effective Concentration and Volume of Ropivacaine for Sacral Plexus Anesthesia Low-dose ropivacaine, Medium-dose of ropivacaine, High-dose ropivacaine - Pediatric ALL | Phase 4 | Enrolling by invitation | Yilin Zhao | 180 | 2024-05-10 | 2024-12-02 |
| Belimumab After Rituximab in Resistant Primary Juvenile SS Rituximab, Belimumab - Sjogren's Syndrome, Pediatric ALL | Phase 4 | Recruiting | Peking Union Medical College Hospital | 15 | 2024-03-09 | 2024-05-16 |
| The Occurrence of Emergence Agitation in Pediatric Strabismus Surgery Bridion 200 MG in 2 ML Injection, Pyridostigmine Bromide 5 MG/ML - Emergence Delirium, Strabismus | Phase 4 | Completed | Konkuk University Medical Center | 76 | 2023-12-01 | 2026-07-15 |
| Hepatoprotective Measures for Children at High Risk of NAFLD Ursodeoxycholic Acid 250 Mg Oral Capsule, Omega -3 fatty acids, Physical exercise - Non Alcoholic Fatty Liver Diseases (NAFLD), Obesity and Overweight | Phase 4 | Active not recruiting | Ain Shams University | 200 | 2023-11-19 | 2025-04-09 |
| Hepatoprotective for Children and Adolescent With Acute Lymphoblastic Leukemia Dietary modification, Supplementation of omega 3 fatty acids - Leukaemia (Acute), Acute Lymphoblastic Leukemia | Phase 4 | Recruiting | Ain Shams University | 42 | 2023-11-17 | 2025-04-09 |
| A Study of Inotuzumab Ozogamicin in Chinese Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia inotuzumab ozogamicin - Acute Lymphoblastic Leukemia | Phase 4 | Completed | Pfizer | 44 | 2023-02-24 | 2025-12-03 |
| South China Children Cancer Group - Relapsed-Acute Lymphoblastic Leukemia 2022 Protocol Realgar Indigo naturalis formula, Conventional chemotherapy - Arsenic Trioxide, Childhood ALL | Phase 4 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 210 | 2022-09-27 | 2023-01-12 |
| Investigating the Effects of Hydroxyvitamin D3 on Multiple Sclerosis 25(OH)D3, vitamin D3 - Multiple Sclerosis, Relapsing-Remitting, Adult ALL | Phase 4 | Unknown | Tehran University of Medical Sciences | 54 | 2022-07-01 | 2022-04-22 |
| Efficacy of the Use of Bortezomib for the Treatment of Relapsed Leukemia or Positive MRD Bortezomib - Acute Lymphoblastic Leukemia, in Relapse, Chemotherapeutic Toxicity | Phase 4 | Unknown | Hospital General de Mexico | 56 | 2021-12-12 | 2022-01-18 |
| Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia Simvastatin - Strains, Acute Lymphoblastic Leukemia | Phase 4 | Unknown | Hospital General de Mexico | 108 | 2021-11-19 | 2022-01-04 |
| Flumatinib Versus Imatinib Combined With Chemotherapy for de Novo Ph+ ALL Flumatinib, Imatinib - Acute Leukemia | Phase 4 | Terminated | Institute of Hematology & Blood Diseases Hospital, China | 39 | 2021-09-16 | 2025-05-01 |
| Feasibility Study to Evaluate Outpatient Blinatumomab in Subjects With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia (ALL) Blinatumomab, Current Wearable Heatlth Monitoring System (CWHMS) - B-precursor Acute Lymphoblastic Leukemia | Phase 4 | Terminated | Amgen | 10 | 2021-08-26 | 2025-05-18 |
| Nalbuphine Versus Ketamine for Prevention of Emergence Agitation After Sevoflurane in Children Undergoing Tonsillectomy Nalbuphine Injection, Ketamine, Saline - Pediatric ALL, Pediatric Anesthesia | Phase 4 | Completed | Ain Shams University | 90 | 2021-03-25 | 2022-01-04 |
| Regional Anesthesia for Totally Awake Upper Limb Surgery in PEDiatric Population local anaesthetic injection - Surgery, Anesthesia, Local | Phase 4 | Completed | GCS Ramsay Santé pour l'Enseignement et la Recherche | 100 | 2020-10-14 | 2026-07-16 |
| N-Acetylcysteine vs Placebo as Adjunctive Treatment in Pediatric Leukemia N-Acetylcysteine, Placebo - Lymphoblastic Leukemia, Acute, Childhood | Phase 4 | Terminated | Teny Tjitra Sari | 16 | 2019-08-29 | 2022-11-09 |
| A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients inotuzumab ozogamicin-dose level 2, Inotuzumab ozogamicin-dose level 1 - Leukemia, Precursor b-Cell Lymphoblastic Leukemia-Lymphoma | Phase 4 | Completed | Pfizer | 102 | 2019-07-01 | 2023-11-22 |
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Leukemia (5) · Neoplasm, Residual (5) · Febrile Neutropenia (4) · Leukemia, Myeloid, Acute (4) · Lymphoma (4) · Lymphoma, Non-Hodgkin (4) · Recurrence (3) · Burkitt Lymphoma (2) · Emergence Delirium (2) · Myelodysplastic Syndromes (2) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (2) · Anemia (1) · Anemia, Aplastic (1) · Anxiety Disorders (1)
Hemic and Lymphatic Diseases (62) · Lymphatic Diseases (62) · Lymphoproliferative Disorders (62) · Neoplasms by Histologic Type (62) · Hematologic Diseases (61) · Immune System Diseases (61) · Immunoproliferative Disorders (61) · Leukemia, Lymphoid (61) · Neoplasms (61) · Leukemia (57) · Pathological Conditions, Signs and Symptoms (14) · Pathologic Processes (12) · Neoplastic Processes (6) · Leukemia, Myeloid (5) · Lymphoma (5)
Vincristine (20) · Cytarabine (19) · Methotrexate (18) · Cyclophosphamide (17) · Dexamethasone (17) · Mercaptopurine (16) · Asparaginase (12) · Daunorubicin (12) · Doxorubicin (10) · Prednisolone (9) · Granulocyte Colony-Stimulating Factor (8) · Etoposide (7) · Idarubicin (7) · Prednisone (6) · Rituximab (6)
PETHEMA Foundation (7) · Goethe University (5) · Ain Shams University (3) · Chinese Academy of Medical Sciences (2) · Gadjah Mada University (2) · Hospital General de Mexico (2) · Johann Wolfgang Goethe University Hospital (2) · Pfizer (2) · St. Jude Children's Research Hospital (2) · Amgen (1) · Astes (1) · Brooke Army Medical Center (1) · Canadian Immunization Research Network (1) · Charite University, Berlin, Germany (1) · GCS Ramsay Santé pour l'Enseignement et la Recherche (1)
China (13) · United States (11) · Germany (10) · Spain (9) · Egypt (3) · Hungary (3) · Indonesia (3) · Italy (3) · Singapore (3) · Austria (2) · Belgium (2) · Canada (2) · Denmark (2) · France (2) · Mexico (2)
Dieter Hoelzer, MD,PhD (4) · Adolfo Martinez Tovar, PhD (2) · Bastida Pilar, Dr (2) · Dieter Hoelzer, MD, PhD (2) · Xiaofan Zhu, MD (2) · Ajay Vora (1) · Alexander Ngwube, MD (1) · Ali McMichael, MD (1) · Allen Yeoh, MBBS (1) · Barry R. Meisenberg, MD (1) · Changgang Li, M.D. (1) · Christina Peters, Prof. MD PhD (1) · Dieter Hoelzer, MD (1)
PMID 19144982, PMID 22442346, PMID 22493293, PMID 23024237, PMID 27561722, PMID 28751559, PMID 11863096, PMID 14585365, PMID 14752084, PMID 15014526, PMID 15158091, PMID 15257960, PMID 15770833, PMID 17223475, PMID 17410187, PMID 18626005, PMID 19167677, PMID 19564304, PMID 19951974, PMID 21828124, PMID 21940824, PMID 22677206, PMID 22966847, PMID 23317527, PMID 23383989, PMID 23775972, PMID 24752047, PMID 25253770, PMID 25359988, PMID 26001791, PMID 26230956, PMID 28116786, PMID 30044693, PMID 30208456, PMID 30872105, PMID 30957229, PMID 31554370, PMID 31644328, PMID 32067048, PMID 32519032, PMID 33041718, PMID 33305842, PMID 33875811, PMID 34010787, PMID 35622074, PMID 35714315, PMID 35911824, PMID 37276496, PMID 39585174, PMID 39882642
2005 (1), 2018 (1), 2019 (1), P01CA128115 (1), P30CA021765 (1), R01CA078957 (1), U01CA081445 (1)