6 completed, 3 terminated, 1 no longer available, 1 withdrawn. 7 Phase 3, 2 Phase 2, 1 Phase 1.
By phase and status
Follow lixivaptan: new trials by email Literature Review of lixivaptan trials Research Report on lixivaptan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|
Roll-over Study to Assess Safety of Lixivaptan in Participants With ADPKD Who Completed Study PA-ADPKD-303
Lixivaptan - Polycystic Kidney Disease, Adult | Phase 3 | Terminated | Palladio Biosciences | 1 | 2022-02-10 | 2023-05-12 |
Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease
Lixivaptan, Placebo - Autosomal Dominant Polycystic Kidney, ADPKD | Phase 3 | Terminated | Palladio Biosciences | 12 | 2021-10-28 | 2023-02-06 |
Safety of Lixivaptan in Subjects Previously Treated With Tolvaptan for Autosomal Dominant Polycystic Kidney Disease
Lixivaptan - Polycystic Kidney Disease, Adult, ADPKD | Phase 3 | Terminated | Palladio Biosciences | 7 | 2020-09-02 | 2023-04-10 |
The ELiSA Study - Evaluation of Lixivaptan in Subjects With Autosomal Dominant Polycystic Kidney Disease
Lixivaptan - Autosomal Dominant Polycystic Kidney Disease | Phase 2 | Completed | Palladio Biosciences | 31 | 2018-09-14 | 2022-12-05 |
Study to Evaluate the Effects of Oral Administration of Lixivaptan in Patients With Congestive Heart Failure
Lixivaptan, Placebo - Congestive Heart Failure | Phase 2 | Completed | CardioKine Inc. | 170 | 2010-01-01 | 2011-06-28 |
International, Multicenter, Open-Label and Randomized Withdrawal Study of Oral Lixivaptan in Heart Failure Patients With Chronic Hyponatremia
Lixivaptan - Hypervolemic Hyponatremia | Phase 3 | Withdrawn | CardioKine Inc. | 300 | 2009-07-01 | 2010-11-23 |
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia
Lixivaptan, Placebo - Euvolemic Hyponatremia | Phase 3 | Completed | CardioKine Inc. | 206 | 2009-06-01 | 2011-06-28 |
A Study to Define the ECG Effects of Lixivaptan Compared to Placebo and Moxifloxacin in Healthy Adult Men and Women: A Thorough ECG Study
placebo, lixivaptan, moxifloxacin - Healthy | Phase 1 | Completed | CardioKine Inc. | 298 | 2008-05-01 | 2011-06-21 |
Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia
lixivaptan, placebo - Hyponatremia With Normal Extracellular Fluid Volume | Phase 3 | Completed | CardioKine Inc. | 106 | 2008-04-01 | 2011-06-28 |
THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation
lixivaptan, Placebo - Hyponatremia | Phase 3 | Completed | CardioKine Inc. | 652 | 2007-01-01 | 2011-06-28 |
Lixivaptan in a Single Subject With Intractable Pain Due to Polycystic Kidney Disease
Lixivaptan - Polycystic Kidney | | No longer available | Palladio Biosciences | | | 2021-10-14 |
Conditions studied
Edema (4) · Polycystic Kidney, Autosomal Dominant (4) · Heart Failure (2) · Hyponatremia (2) · Inappropriate ADH Syndrome (1) · Polycystic Kidney Diseases (1)
Sponsors
CardioKine Inc. (6) · Palladio Biosciences (5)
Countries
United States (10) · India (3) · Poland (3) · Belgium (2) · Canada (2) · Czechia (2) · Germany (2) · Israel (2) · Italy (2) · Spain (2) · Argentina (1) · Australia (1) · Bulgaria (1) · Chile (1) · Hungary (1)
Top investigators
Arlene Chapman, MD (1) · Marie C Hogan, MD, PhD (1) · Nelson Kopyt, DO (1) · Vicente E Torres, MD, PhD (1) · Vicente Torres, MD, PhD (1)
Results publications
PMID 22510424