6 recruiting, 5 unknown, 2 completed, 1 active not recruiting. 8 Not applicable, 2 Phase 1, 2 Phase 2, 2 Phase 3.
Follow Periprosthetic Joint Infection: new trials by email Literature Review of Periprosthetic Joint Infection trials Research Report on Periprosthetic Joint Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections REMEDY Spectrum IM Spacer Nail - Periprosthetic Joint Infection | Phase 2 | Recruiting | OsteoRemedies, LLC | 60 | 2026-02-01 | 2026-05-19 |
| Rifampin-combined Antibiotic Therapy for Staphylococcal PJI Rifampicin (R) - Periprosthetic Joint Infection | Not applicable | Recruiting | First Affiliated Hospital of Fujian Medical University | 428 | 2025-11-13 | 2025-12-31 |
| Phage Therapy for the Treatment of a Chronic Enterococcus Faecium Periprosthetic Joint Infection Phage Therapy - Periprosthetic Joint Infection | Phase 1 / Phase 2 | Not yet recruiting | Orthopaedic Innovation Centre | 1 | 2025-05-01 | 2025-04-24 |
| Proper Duration of Suppressive Antibiotic Therapy After Debridement, Antibiotics, and Implant Retention 6 months of SAT, 12 months of SAT, Indefinite SAT - Periprosthetic Joint Infection, Antibiotic Suppression | Not applicable | Withdrawn | University of Maryland, Baltimore | 2024-12-01 | 2026-02-10 | |
| Optimizing Infection Prophylaxis Prior to Shoulder Surgery Chlorhexidine Gluconate - Arthroplasty Shoulder, Periprosthetic Joint Infection | Not applicable | Recruiting | University of Washington | 40 | 2024-08-31 | 2024-12-05 |
| Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial Cefazolin with Daptomycin, Cefazolin with vancomycin - Periprosthetic Joint Infection | Not applicable | Unknown | Chang Gung Memorial Hospital | 184 | 2024-08-01 | 2024-01-05 |
| Infection Prophylaxis in Total Joint Replacement Chlorhexidine Gluconate, Vancomycin Hydrochloride, Povidone-Iodine - Periprosthetic Joint Infection | Phase 3 | Recruiting | Hamilton Health Sciences Corporation | 21006 | 2024-05-07 | 2026-05-22 |
| A Diagnostic Test Accuracy Study Comparing Biopsy to Aspiration in Shoulder and Elbow Arthroplasty Revision Surgery (BASE Study) Periprosthetic Joint Infection | Recruiting | Wrightington, Wigan and Leigh NHS Foundation Trust | 244 | 2024-03-20 | 2025-07-28 | |
| Use of Phage Therapy for Treatment of a Periprosthetic Joint Infection Phage (Cytophage Technologies) - Periprosthetic Joint Infection | Phase 1 | Active not recruiting | Ottawa Hospital Research Institute | 1 | 2024-02-22 | 2025-02-14 |
| Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention - Periprosthetic Joint Infection | Not applicable | Enrolling by invitation | Mayo Clinic | 490 | 2023-03-03 | 2025-12-18 |
| Diagnosis and Bacterial Identification of Periprosthetic Joint Infection With Microbial-ID Microbial ID test - Periprosthetic Joint Infection, PJI | Unknown | UMC Utrecht | 200 | 2022-04-25 | 2023-02-23 | |
| Closed Incisional Negative Pressure Wound Therapy in Post-surgical Wound Care of Patients With Periprosthetic Joint Infection PREVENA incision management system - Wound Heal, Periprosthetic Joint Infection | Not applicable | Unknown | Chang Gung Memorial Hospital | 70 | 2022-03-15 | 2022-05-02 |
| Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement Povidone-Iodine Lavage Solution, Chlorhexidine Lavage Solution, Topical Antibiotic - Periprosthetic Joint Infection, Draining Wound | Phase 3 | Completed | McMaster University | 495 | 2022-03-11 | 2026-10-07 |
| Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI. Antibiotics treatment - Periprosthetic Joint Infection, Anti-Bacterial Agents | Recruiting | First Affiliated Hospital of Fujian Medical University | 500 | 2021-12-01 | 2022-03-17 | |
| Microbial Growth in Operative Splash Basins During Total Joint Arthroplasty Sterile Water, 3.5% Betadine, 0.05% Chlorhexidine Gluconate - Periprosthetic Joint Infection | Not applicable | Terminated | University of Southern California | 30 | 2021-01-16 | 2023-02-09 |
| Clinical Validation of CD Diagnostics Synovasure PJI ELISA Test and Synovasure PJI Lateral Flow Test for Detection of Periprosthetic Joint Infection in Synovial Fluid Synovasure PJI Lateral Flow test and Synovasure PJI ELISA Test - Periprosthetic Joint Infection | Unknown | CD Diagnostics | 3000 | 2016-07-01 | 2016-08-16 | |
| Intraoperative Microbial Contamination Ioban - Periprosthetic Joint Infection | Not applicable | Completed | University of Copenhagen | 1661 | 2016-03-01 | 2018-10-15 |
| Arthrocentesis Study Periprosthetic Joint Infection, Septic Arthritis | Unknown | Charite University, Berlin, Germany | 400 | 2014-11-01 | 2015-08-21 |
Arthritis (1) · Infections (1) · Joint Diseases (1) · Musculoskeletal Diseases (1)
chlorhexidine gluconate (3) · Anti-Bacterial Agents (2) · Povidone-Iodine (2) · Vancomycin (2) · Cefazolin (1) · Daptomycin (1) · Debridement (1) · Phage Therapy (1) · Rifampin (1) · Sodium Chloride (1) · diamine N-acetyltransferase (1)
Chang Gung Memorial Hospital (2) · First Affiliated Hospital of Fujian Medical University (2) · CD Diagnostics (1) · Charite University, Berlin, Germany (1) · Hamilton Health Sciences Corporation (1) · Mayo Clinic (1) · McMaster University (1) · Orthopaedic Innovation Centre (1) · OsteoRemedies, LLC (1) · Ottawa Hospital Research Institute (1) · UMC Utrecht (1) · University of Copenhagen (1) · University of Maryland, Baltimore (1) · University of Southern California (1) · University of Washington (1)
United States (6) · Canada (4) · China (2) · Germany (2) · Spain (2) · Taiwan (2) · Denmark (1) · Netherlands (1) · Portugal (1) · Slovenia (1) · Switzerland (1) · United Kingdom (1)
Andrej Trampuz, MD (1) · David Hedden, MD (1) · Harrie Weinans, Prof, MD (1) · Jason Hsu, MD (1) · Marisa A Azad, MD PhD (1) · Matthew Abdel, MD (1) · Rachel McGuire Kennedy (1) · Thomas Bjarnsholt (1) · Thomas J Wood, MD, FRCSC (1) · Thomas Wood, MD (1) · Wenming Zhang, MD (1)
PMID 30219763, PMID 32290833, PMID 32493292, PMID 35395437, PMID 40652382