5 active not recruiting, 5 not yet recruiting, 5 recruiting, 3 completed. 13 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Active not recruiting 4, Recruiting 4, Not yet recruiting 3, Completed 2 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 4 | 1 | Enrolling by invitation 1 |
Follow Paroxysmal AF: new trials by email Literature Review of Paroxysmal AF trials Research Report on Paroxysmal AF
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CENTAURI Post-Market Clinical Registry CENTAURI System in conjunction with commercially available ablation catheters - Paroxysmal AF | Not yet recruiting | CardioFocus | 300 | 2026-12-01 | 2026-10-14 | |
| Conduction Breakthrough in the Coronary Sinus Post Endocardial Mitral Isthmus Ablation Atrial Fibrillation (AF), Atrial Tachycardia | Not yet recruiting | Sebastien Knecht | 50 | 2026-10-01 | 2026-10-22 | |
| Dose Escalation Study to Assess Safety, Tolerability, and Efficacy of Budiodarone Treatment With Non-permanent Atrial Fibrillation Budiodarone 200 mg BID, Budiodarone 400 mg BID, Budiodarone 600 mg BID - Atrial Fibrillation (AF), Paroxysmal AF | Phase 2 | Recruiting | Xyra, LLC | 100 | 2026-08-06 | 2026-08-28 |
| PulseMagic™ TrueForce™ PAF NMPA Study PFA Ablation catheter - Atrial Fibrillation (AF), Paroxysmal AF | Not applicable | Not yet recruiting | Shanghai MicroPort EP MedTech Co., Ltd. | 150 | 2026-07-10 | 2026-07-22 |
| The Effect of Pulse Field Ablation of Atrial Fibrillation Involving Posterior Wall Ablation on Atrial Mechancis Assessed by Cardiac Magnetic Resonance Imaging Atrial fibrillation ablation procedure planned using pulsed-field ablation and including at least pulmonary vein isolation and posterior wall isolation - Persistant Atrial Fibrillation, Paroxysmal AF | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 39 | 2026-04-01 | 2026-03-30 |
| Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration PVI Ablation, Left Atrial Appendage Occluder Implant - Atrial Fibrillation (AF), Paroxysmal AF | Not applicable | Recruiting | Abbott Medical Devices | 240 | 2026-03-31 | 2026-07-13 |
| Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Affera™ Mapping and Ablation System (Horizon 360) Sphere-360 Pulsed Field Ablation Catheter with the Affera Mapping and Ablation System - Paroxysmal AF | Not applicable | Active not recruiting | Medtronic Cardiac Ablation Solutions | 300 | 2026-01-15 | 2026-09-02 |
| Comparative Efficacy of 100-, 200-, & 400-mg Amiodarone in Patients With Paroxysmal AF Depending on Plasma Concentration Pharmacotherapy with amiodarone 200 mg per day, Treatment with Amiodarone at a dose 100 mg per day, Treatment with Amiodarone at a dose 400 mg per day - Paroxysmal AF, Treatment Decisions | Phase 4 | Enrolling by invitation | Tomsk National Research Medical Center of the Russian Academy of Sciences | 80 | 2026-01-12 | 2026-03-23 |
| BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF Pulsed Field Ablation - Paroxysmal AF, Atrial Arrhythmia | Not applicable | Active not recruiting | Abbott Medical Devices | 300 | 2025-12-11 | 2026-10-21 |
| FARAPULSE™ Pulsed Field Ablation System FARAPULSE™ Pulsed Field Ablation system - Paroxysmal AF | Active not recruiting | Boston Scientific Corporation | 501 | 2025-10-23 | 2026-09-25 | |
| Durability of Pulmonary Vein Isolation Using a Variable-Loop Biphasic Pulsed Field Ablation Catheter in Patients With Paroxysmal Atrial Fibrillation Pulmonary vein isolation with the VariPulse catheter - Paroxysmal AF | Not applicable | Active not recruiting | Erasmus Medical Center | 20 | 2025-09-27 | 2026-09-11 |
| Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation Argá Medtech Coherent Sine-Burst Electroporation (CSE) Ablation System - Atrial Fibrillation (AF), Persistant Atrial Fibrillation | Not applicable | Recruiting | Arga Medtech SA | 360 | 2025-09-10 | 2026-07-15 |
| SVC-isolation in Redo-AF Ablation With Isolated PV Empirical superior vena cava isolation, Ablation without empirical superior vena cava isolation - Paroxysmal AF | Not applicable | Not yet recruiting | Centro Medico Teknon | 100 | 2025-09-01 | 2025-08-08 |
| Feasibility Study of the FARAFLEX Mapping and PFA System FARAFLEX Ablation Treatment, ELEVATE-COR Sub-study - Atrial Fibrillation, Persistent Atrial Fibrillation | Not applicable | Recruiting | Boston Scientific Corporation | 250 | 2025-02-17 | 2026-09-24 |
| Evaluation of the Impact of Pulsed Field Ablation on Autonomic Nervous System Modulation in Paroxysmal Atrial Fibrillation PF-only PVI, Hybrid PVI, RF-only PVI - Atrial Fibrillation (AF), Paroxysmal AF | Not applicable | Recruiting | VZW Cardiovascular Research Center Aalst | 105 | 2025-01-29 | 2025-07-10 |
| A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF: PFA Ablation catheter - Atrial Fibrillation (AF), Atrial Arrhythmia | Not applicable | Completed | Abbott Medical Devices | 188 | 2024-11-22 | 2026-06-01 |
| 3-Dimensional Mapping System: The PULSTAR II Study Nanosecond pulsed electric field ablation system; Cardiac Pulsed Electric Field Ablation Catheter - Atrial Fibrillation (Paroxysmal), Paroxysmal AF | Not applicable | Active not recruiting | Shanghai Shangyang Medical Technology Co., Ltd. | 152 | 2024-10-10 | 2026-05-14 |
| AblaView® Unipolar PFA OCR-guided Feasibility Study - First in Man AblaView® Unipolar PFA System - Paroxysmal AF | Not applicable | Completed | Medlumics | 10 | 2024-09-08 | 2025-03-28 |
| CARTO® 3 System and Real Time Intracardiac Ultrasound Catheter Ablation - Atrial Fibrillation, Paroxysmal AF | Completed | Biosense Webster, Inc. | 234 | 2012-10-01 | 2014-12-01 |
Atrial Fibrillation (19) · Recurrence (2)
Arrhythmias, Cardiac (19) · Cardiovascular Diseases (19) · Heart Diseases (19) · Pathologic Processes (19) · Pathological Conditions, Signs and Symptoms (19) · Disease Attributes (2)
Amiodarone (1) · BID protein, human (1) · Catheter Ablation (1) · Drug Therapy (1) · Therapeutics (1) · budiodarone (1)
Abbott Medical Devices (3) · Boston Scientific Corporation (2) · Arga Medtech SA (1) · Assistance Publique - Hôpitaux de Paris (1) · Biosense Webster, Inc. (1) · CardioFocus (1) · Centro Medico Teknon (1) · Erasmus Medical Center (1) · Medlumics (1) · Medtronic Cardiac Ablation Solutions (1) · Sebastien Knecht (1) · Shanghai MicroPort EP MedTech Co., Ltd. (1) · Shanghai Shangyang Medical Technology Co., Ltd. (1) · Tomsk National Research Medical Center of the Russian Academy of Sciences (1) · VZW Cardiovascular Research Center Aalst (1)
Belgium (5) · Netherlands (4) · United States (4) · China (3) · Czechia (3) · Italy (3) · Lithuania (3) · Poland (3) · Spain (3) · Austria (2) · Croatia (2) · Denmark (2) · Germany (2) · Ireland (2) · France (1)
Ahmad Abdul-Karim, MD (1) · Andy Tran, MD (1) · Antonio Berruezo, MD, PhD (1) · Asim Yunus, MD (1) · Askar Sabirov, MD (1) · Atul Verma, MD, PhD (1) · Brett Gidney, MD (1) · David Fitzgerald, MD (1) · Dilip Mathew, MD (1) · Douglas Esberg, MD (1) · Farhat Khairallah, MD (1) · Giorgi Papiashvili, MD, PhD (1) · Gopi Dandamudi, MD (1) · Gregory Jones, MD (1) · Gunjan Shukla, MD (1)
2025 (1)