1 completed, 1 not yet recruiting, 1 recruiting, 1 terminated. 1 Phase 1, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Pain Crisis: new trials by email Literature Review of Pain Crisis trials Research Report on Pain Crisis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Buprenorphine for the Management of Pain in Children With Sickle Cell Disease Buprenorphine Buccal Film [Belbuca] - Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis | Phase 1 | Not yet recruiting | Natasha Archer | 25 | 2027-01-01 | 2026-11-04 |
| Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Disease Rivipansel - Sickle Cell Anemia, Sickle Cell Disease | Phase 3 | Terminated | GlycoMimetics Incorporated | 154 | 2015-12-16 | 2021-02-10 |
| Study of GMI-1070 for the Treatment of Sickle Cell Pain Crisis GMI-1070, Placebo - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 2 | Completed | GlycoMimetics Incorporated | 81 | 2010-05-01 | 2020-05-13 |
| Natural History of Sickle Cell Disease Pain Crisis | Recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 3500 | 2004-04-29 | 2026-10-21 |
Anemia, Sickle Cell (3) · Vaso-Occlusive Crises (3) · Acute Chest Syndrome (1) · Acute Pain (1) · Hemoglobin SC Disease (1) · Hypertension, Pulmonary (1)
Anemia (4) · Anemia, Hemolytic (4) · Anemia, Hemolytic, Congenital (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Genetic Diseases, Inborn (4) · Hematologic Diseases (4) · Hemic and Lymphatic Diseases (4) · Hemoglobinopathies (4) · Anemia, Sickle Cell (1) · Cardiovascular Diseases (1) · Hypertension (1) · Lung Diseases (1) · Neurologic Manifestations (1) · Pain (1) · Pathological Conditions, Signs and Symptoms (1)
rivipansel (2) · Buprenorphine (1)
GlycoMimetics Incorporated (2) · Natasha Archer (1) · National Heart, Lung, and Blood Institute (NHLBI) (1)
United States (4) · Canada (2)
Helen Thackray, MD (1) · Marilyn J Telen, MD (1) · Natasha Archer, MD (1) · Swee Lay Thein, M.D. (1)
PMID 19536844, PMID 20378559, PMID 22129980, PMID 23828202, PMID 24916507, PMID 25733584, PMID 26589907, PMID 29419434, PMID 33661274, PMID 35120836, PMID 35981565, PMID 39659429