9 completed, 3 recruiting, 1 terminated, 1 unknown. 10 Not applicable, 2 Phase 1, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 9, Recruiting 1 |
| Phase 1 | 2 | Recruiting 1, Terminated 1 |
| Early Phase 1 | 1 | Unknown 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Nicotine Vaping: new trials by email Literature Review of Nicotine Vaping trials Research Report on Nicotine Vaping
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors quitSTART Mobile Application, Chatbot Feature in quitSTART Mobile Application - Nicotine Vaping, Nicotine Use Disorder | Phase 1 | Terminated | Washington University School of Medicine | 26 | 2025-06-04 | 2026-10-26 |
| Kick-Nic! Youth Quit Vaping App Kick-Nic! mobile phone application, NCI Quit Vaping website - Nicotine Vaping | Phase 2 | Recruiting | Yale University | 306 | 2025-01-07 | 2026-07-31 |
| Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine (S)-Nicotine, (R)- nicotine, Racemic nicotine - Nicotine Dependence, Nicotine Vaping | Phase 1 | Recruiting | University of California, San Francisco | 18 | 2024-12-06 | 2026-05-14 |
| Pilot Study of the YES-CAN! Program to Prevent Youth Nicotine Vaping YES-CAN! program - Nicotine Vaping | Not applicable | Recruiting | University of Colorado, Denver | 1166 | 2024-08-15 | 2025-07-15 |
| Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Heated tobacco products at 1/2 market price. - Cigarette Smoking, Nicotine Vaping | Not applicable | Completed | Virginia Polytechnic Institute and State University | 440 | 2024-07-29 | 2026-04-22 |
| A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults Smartphone app, Text Message, Survey Administration - Nicotine Dependence, Nicotine Addiction | Not applicable | Completed | Fred Hutchinson Cancer Center | 61 | 2024-01-04 | 2025-06-24 |
| Promotion and Mitigation Factors Leading to Illegal Tobacco Purchases Promotion factors, Mitigation strategies - Cigarette Smoking, Nicotine Vaping | Not applicable | Completed | Virginia Polytechnic Institute and State University | 65 | 2024-01-04 | 2026-02-10 |
| Nicotine and Pavlovian Bias Nicotine, Placebo - Nicotine Vaping, Nicotine Dependence | Early Phase 1 | Unknown | University of Southern California | 40 | 2023-10-25 | 2023-11-09 |
| Developing E-liquid Product Standards (Sweet Spot Study) Vaping study EC A, Vaping study EC B, Vaping study EC C - Nicotine, Nicotine Vaping | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 150 | 2023-05-30 | 2025-04-10 |
| Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes Nicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine) - Nicotine Vaping | Not applicable | Completed | Yale University | 36 | 2023-02-01 | 2025-11-18 |
| Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence P4M3 CA35, P4M3 CM35, CIG - Nicotine, Vaping | Not applicable | Completed | Philip Morris Products S.A. | 74 | 2022-07-15 | 2024-03-13 |
| Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency e-liquid 1, e-liquid 2, e-liquid 3 - Nicotine Vaping, Nicotine Dependence | Not applicable | Completed | American University of Beirut Medical Center | 142 | 2022-07-13 | 2026-09-18 |
| Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Nicotine vaping products at 2x market price - Cigarette Smoking, Nicotine Vaping | Not applicable | Completed | Virginia Polytechnic Institute and State University | 60 | 2022-06-29 | 2025-01-30 |
| Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes CA35, CM35, Cig - Nicotine Vaping, Nicotine | Not applicable | Completed | Philip Morris Products S.A. | 36 | 2022-04-28 | 2024-04-26 |
Vaping (14) · Tobacco Use Disorder (5) · Cigarette Smoking (3) · Smoking (2)
Behavior (14) · Smoking (12) · Chemically-Induced Disorders (5) · Mental Disorders (5) · Substance-Related Disorders (5) · Tobacco Smoking (3) · Tobacco Use (3)
Nicotine (3) · Fibronectins (1) · Tobacco Products (1) · nicotine 1-N-oxide (1)
Virginia Polytechnic Institute and State University (3) · Philip Morris Products S.A. (2) · Yale University (2) · American University of Beirut Medical Center (1) · Fred Hutchinson Cancer Center (1) · Ohio State University Comprehensive Cancer Center (1) · University of California, San Francisco (1) · University of Colorado, Denver (1) · University of Southern California (1) · Washington University School of Medicine (1)
United States (12) · Lebanon (1) · United Kingdom (1)
Warren K Bickel, Ph.D. (2) · Jaimee Heffner (1) · Lori A Crane, PhD, MPH (1) · Melanie Fein, MD (1) · Nancy L Asdigian, PhD (1) · Neal Benowitz, MD (1) · Patrick Winiger, MD (1) · Roberta Freitas-Lemos, Ph.D. (1) · Soha Talih, PhD (1) · Stephen R Baldassarri, M.D. (1) · Suchitra Krishnan-Sarin, Ph.D. (1) · Theodore L Wagener, PhD (1)
PMID 37733666, PMID 37699050, PMID 40411791
P01CA200512 (2), R01DA052565 (2), R01CA285216 (1), R01DA057282 (1), R34DA054725 (1), R34DA058218 (1), UG3DA057032 (1)