29 completed, 6 recruiting, 5 unknown, 5 withdrawn. 51 Phase 2, 10 Phase 1, 8 Phase 3.
Follow Nephrolithiasis: new trials by email Literature Review of Nephrolithiasis trials Research Report on Nephrolithiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH). TRA16, Placebo - Enteric Hyperoxaluria | Phase 2 | Not yet recruiting | Wuhan Kangfude Urolithiasis Research Institute Co., Ltd. | 30 | 2027-03-01 | 2026-10-13 |
| The GranStone Trial empagliflozin (Jardiance) 25 mg, Losartan 100 mg - Paraffinoma, Granuloma, Foreign-Body | Phase 2 / Phase 3 | Recruiting | Martin Blomberg Jensen | 100 | 2026-10-20 | 2026-11-10 |
| Study of YOLT-203 in Children and Adults With Primary Hyperoxaluria Type 1 (PH1) YOLT-203, Placebo - Primary Hyperoxaluria Type 1, PH1 | Phase 2 | Recruiting | YolTech Therapeutics Co., Ltd | 36 | 2026-09-16 | 2026-10-09 |
| Dexamethasone for Ureteral STent Symptoms (DUSTS) Dexamethasone Sodium Phosphate Injection 20 mg, Dexamethasone Sodium Phosphate Injection 4mg - Ureteral Stent-Related Symptom | Phase 1 / Phase 2 | Recruiting | The Methodist Hospital Research Institute | 70 | 2026-06-10 | 2026-10-30 |
| Tamsulosin and Intraureteral Aminophylline for Ureteral Access During RIRS Tamsulosin, Placebo Capsule, Intraureteral Aminophylline - Renal Stones, Retrograde Intrarenal Surgery | Phase 2 | Recruiting | Beni-Suef University | 322 | 2026-05-06 | 2026-06-03 |
| Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones Potassium Citrate, Sodium Bicarbonate - Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis | Phase 1 / Phase 2 | Not yet recruiting | University of California, Los Angeles | 30 | 2026-02-01 | 2026-02-12 |
| Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain Bupivacaine, Normal saline - Nephrolithiasis | Phase 2 | Recruiting | University of Chicago | 116 | 2025-03-26 | 2026-10-13 |
| A Phase 2a Study of LLX-424 in Patients With a History of Kidney Stones LLX-424 - Kidney Stones | Phase 2 | Completed | Lilac Therapeutics, Inc. | 51 | 2025-03-23 | 2025-10-29 |
| Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention Indapamide 2.5 MG, Hydrochlorothiazide 50Mg, Chlorthalidone 25mg - Kidney Stone | Phase 2 | Recruiting | Insel Gruppe AG, University Hospital Bern | 99 | 2024-10-01 | 2026-05-06 |
| Flexible Mini Percutaneous Nephrolithotomy Vs Retrograde Intra-renal Surgery flexible mini percutaneous nephrolithotomy, Retrograde intrarenal surgery - Renal Stone | Phase 2 / Phase 3 | Completed | Ain Shams University | 130 | 2024-01-01 | 2024-10-29 |
| Erector Spinae Plane Block for Uncomplicated Renal Colic Erector Spinae Plane Block (ESPB), Ropivacaine - Renal Colic, Kidney Stone | Phase 2 | Completed | University of Michigan | 5 | 2023-02-08 | 2025-10-30 |
| Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence Ure-Na - Kidney Stone | Phase 2 | Withdrawn | Centre hospitalier de l'Université de Montréal (CHUM) | 2023-01-15 | 2022-11-28 | |
| Silodosin in Management of Lower Ureteral Stones Silodosin - Stone, Kidney | Phase 1 / Phase 2 | Completed | Syrian Private University | 100 | 2022-10-20 | 2024-04-24 |
| A Study to Evaluate Lumasiran in Adults With Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate Levels Lumasiran, Placebo - Recurrent Calcium Oxalate Kidney Stone Disease, Elevated Urinary Oxalate Levels | Phase 2 | Terminated | Alnylam Pharmaceuticals | 2 | 2022-01-27 | 2024-05-22 |
| Impact of the SGLT2 Inhibitor Empagliflozin on Urinary Supersaturations in Kidney Stone Formers Empagliflozin 25 MG, Placebo - Kidney Stone | Phase 2 | Completed | Insel Gruppe AG, University Hospital Bern | 50 | 2021-08-25 | 2023-05-12 |
| Effect of Antihistamines on Ureteral Stent-Related Symptoms Fexofenadine Hcl 180Mg Tab, Placebo - Nephrolithiasis | Phase 2 | Completed | Columbia University | 78 | 2021-06-29 | 2025-07-16 |
| Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects NOV-001, NB1000S, NB2000P - Healthy Volunteers, Enteric Hyperoxaluria | Phase 1 / Phase 2 | Terminated | Novome Biotechnologies Inc | 153 | 2021-06-02 | 2023-05-17 |
| Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Fluconazole in Hypercalcicuric Patients With Increased 1.25(OH) 2D Levels Fluconazole, Placebo - Nephrolithiasis, Nephrocalcinosis | Phase 2 | Completed | Hospices Civils de Lyon | 56 | 2021-01-13 | 2024-07-12 |
| Perioperative Pregabalin in Ureteroscopy Pregabalin 300mg, Placebo oral tablet - Kidney Stone, Pain, Postoperative | Phase 2 / Phase 3 | Completed | University of Missouri-Columbia | 118 | 2020-06-01 | 2025-11-12 |
| Pramipexole and Morphine for Renal Colic Pramipexole, Morphine, Placebo oral tablet - Renal Colic | Phase 1 / Phase 2 | Completed | East Carolina University | 19 | 2019-10-28 | 2023-03-08 |
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Kidney Calculi (37) · Urolithiasis (9) · Hyperoxaluria (6) · Kidney Diseases (5) · Calculi (3) · Hypercalciuria (3) · Nephrocalcinosis (3) · Renal Colic (3) · Urinary Calculi (3) · Urologic Diseases (3) · Crohn Disease (2) · Cystinuria (2) · Hypercalcemia (2) · Hyperoxaluria, Primary (2)
Female Urogenital Diseases (51) · Female Urogenital Diseases and Pregnancy Complications (51) · Male Urogenital Diseases (51) · Urogenital Diseases (51) · Urologic Diseases (48) · Kidney Diseases (46) · Urolithiasis (42) · Pathological Conditions, Signs and Symptoms (40) · Pathological Conditions, Anatomical (37) · Calculi (34) · Urinary Calculi (34) · Signs and Symptoms (9) · Neurologic Manifestations (6) · Nutritional and Metabolic Diseases (6)
oxalate decarboxylase (4) · reloxaliase (4) · Hydrochlorothiazide (2) · Isoproterenol (2) · Ketorolac Tromethamine (2) · Potassium Citrate (2) · Saline Solution (2) · empagliflozin (2) · silodosin (2) · Adrenocorticotropic Hormone (1) · Allopurinol (1) · Bupivacaine (1) · Chlorthalidone (1) · Citrates (1) · Citric Acid (1)
Allena Pharmaceuticals (4) · Ain Shams University (2) · Fredericia Hosptial (2) · Insel Gruppe AG, University Hospital Bern (2) · Mayo Clinic (2) · University of Texas Southwestern Medical Center (2) · Albany Medical College (1) · Alnylam Pharmaceuticals (1) · Amai Charitable Trust (1) · Assaf-Harofeh Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Beni-Suef University (1) · Brigham and Women's Hospital (1) · Catalysis SL (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1)
United States (28) · Canada (4) · Denmark (3) · Egypt (3) · Switzerland (3) · France (2) · Italy (2) · United Kingdom (2) · Belgium (1) · Germany (1) · Iceland (1) · India (1) · Iran (1) · Israel (1) · Nicaragua (1)
Annamaria Kausz, MD MS (2) · Thomas Chi, MD (2) · Chris Fung (1) · Daniel Fuster, MD (1) · Daniel G Fuster, M.D. (1) · David Clark, MD (1) · Davis J Viprakasit, MD (1) · Hany F Badawy, MD (1) · Helene U Jung (1) · Jamshid Roozbeh, MD (1) · Jie Tang, M.D., M.Sc (1) · John C Lieske, MD (1) · John D Denstedt, MD, FRCSC (1)
PMID 18976849, PMID 20736987, PMID 21161651, PMID 21419606, PMID 23929928, PMID 30783888, PMID 34569278, PMID 35288397, PMID 35710560, PMID 39411383, PMID 39747681, PMID 39937815
P50DK083007 (2), 2005 (1), 2017 (1), P20DK100863 (1), R21AT002534 (1), R21DK072454 (1), R21DK097476 (1), R21DK109433 (1), UL1RR024150 (1)