12 completed, 3 unknown, 1 not yet recruiting, 1 terminated. 6 Phase 3, 5 Phase 2, 3 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 4, Terminated 1, Unknown 1 |
| Phase 2 | 5 | Completed 5 |
| Not applicable | 3 | Completed 1, Not yet recruiting 1, Unknown 1 |
Follow Nasal Polyposis: new trials by email Literature Review of Nasal Polyposis trials Research Report on Nasal Polyposis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FESS With or Without Intranasal Desmopressin in Chronic Rhinosinusitis With Nasal Polyps Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray, Functional Endoscopic Sinus Surgery - Chronic Sinusitis, Nasal Polyposis | Not applicable | Not yet recruiting | Services Institute of Medical Sciences, Pakistan | 174 | 2026-10-15 | 2026-10-06 |
| Long-term Effect of Dupilumab in N-ERD Observational follow-up of standard Dupilumab treatment - NSAID-Induced Asthma, NSAIDs Hypersensitivity | Completed | Medical University of Vienna | 15 | 2025-09-01 | 2026-10-07 | |
| Development of a Severity Assessment Score for Nasosinus Polyposis (PSI Score) Questionaries - Nasal Polyposis | Completed | Centre Hospitalier Intercommunal Creteil | 569 | 2022-01-27 | 2025-02-03 | |
| Nasality Evolution in a Nasal Polyposis Context : Multiparametric Evaluation : Articulatory (Imaging), Aerodynamics, Acoustics and Perception Nasal Polyposis | Unknown | Assistance Publique - Hôpitaux de Paris | 30 | 2021-12-01 | 2021-11-23 | |
| Smell Exploration in Patients With Nasal Polyposis : Study by Functional Magnetic Resonance Imaging fMRI - Nasal Polyposis | Not applicable | Unknown | Central Hospital, Nancy, France | 60 | 2019-12-23 | 2020-11-19 |
| Efficacy and Safety Study of Benralizumab in Patient With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps (ORCHID) Benralizumab 30 mg, Matched placebo - Nasal Polyposis, Eosinophilic Chronic Rhinosinusitis | Phase 3 | Terminated | AstraZeneca | 295 | 2019-11-25 | 2026-02-19 |
| Efficacy & Safety of OPN-375 Adults With Bilateral Nasal Polyps Using Nasoendoscopic Video Fluticasone Propionate - Nasal Polyposis | Phase 3 | Completed | Optinose US Inc. | 11 | 2018-06-07 | 2020-08-03 |
| Efficacy and Safety Study of Benralizumab for Patients With Severe Nasal Polyposis Benralizumab 30 mg SC + Mometasone Furoate, Matching placebo SC + Mometasone Furoate - Nasal Polyposis | Phase 3 | Completed | AstraZeneca | 413 | 2018-01-15 | 2021-10-12 |
| Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps (ENCORE) S8 Sinus Implant - Chronic Sinusitis, Nasal Polyposis | Phase 3 | Completed | Intersect ENT | 50 | 2017-11-13 | 2019-11-27 |
| Comparison of Methylprednisolone or Methotrexate in the Maintenance Treatment of Nasal Polyposis Emthexate, Prednol, Mometasone Furoate - Nasal Polyposis | Phase 2 | Completed | Dokuz Eylul University | 41 | 2017-09-02 | 2020-08-31 |
| Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Chronic Rhinosinusitis With Nasal Polyposis botox injection Multiguide - Chronic Disease, Nasal Polyposis | Phase 2 | Completed | Norwegian University of Science and Technology | 11 | 2016-10-01 | 2021-11-05 |
| Study to Evaluate Multiple Doses in Patients With Nasal Polyposis AK001 low dose, AK001 high dose, Placebo - Nasal Polyposis | Phase 2 | Completed | Allakos Inc. | 40 | 2016-04-01 | 2021-01-25 |
| The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery MEDIHONEY®, Budesonide, Normal saline sinus rinse - Chronic Sinusitis, Nasal Polyposis | Not applicable | Completed | University of Vermont Medical Center | 40 | 2015-11-01 | 2019-10-16 |
| S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps S8 Sinus Implant, Mometasone furoate nasal spray, Sham - Chronic Sinusitis, Nasal Polyposis | Phase 3 | Completed | Intersect ENT | 300 | 2014-12-01 | 2018-08-15 |
| The Effect of RF Turbinoplasty in Polypoid Change of Middle Turbinates middle turbinate Radio Frequency (RF) turbinoplasty, middle turbinate resection, middle turbinate medialization - Nasal Polyposis, Sinusitis | Phase 3 | Unknown | Tehran University of Medical Sciences | 90 | 2011-05-01 | 2013-07-24 |
| Clinical and Biological Effects of Anti-IgE (Omalizumab) in Patients With Bilateral Nasal Polyposis and Asthma Omalizumab, Placebo - Nasal Polyposis, Asthma | Phase 2 | Completed | University Hospital, Ghent | 23 | 2006-12-01 | 2011-07-13 |
| Double-Blind Randomized Placebo-Controlled Trial on Clinical and Biological Effects of Oral Corticosteroids or Doxycyclin in Patients With Nasal Polyposis Administration of oral methylprednisolone - Nasal Polyposis | Phase 2 | Completed | University Hospital, Ghent | 48 | 2002-11-01 | 2007-12-28 |
Nasal Polyps (17) · Asthma (2) · Asthma, Aspirin-Induced (1) · Bites and Stings (1) · Chronic Disease (1) · Nose Diseases (1) · Otorhinolaryngologic Diseases (1) · Polyps (1) · Respiratory Tract Diseases (1) · Rhinitis (1) · Sinusitis (1)
Pathological Conditions, Anatomical (17) · Pathological Conditions, Signs and Symptoms (17) · Nose Diseases (16) · Otorhinolaryngologic Diseases (16) · Polyps (16) · Respiratory Tract Diseases (16) · Bronchial Diseases (3) · Hypersensitivity (3) · Hypersensitivity, Immediate (3) · Immune System Diseases (3) · Respiratory Hypersensitivity (3) · Chemically-Induced Disorders (2) · Infections (2) · Lung Diseases (2) · Lung Diseases, Obstructive (2)
Mometasone Furoate (3) · benralizumab (2) · Adrenal Cortex Hormones (1) · Botulinum Toxins, Type A (1) · Budesonide (1) · Fluticasone (1) · Magnetic Resonance Imaging (1) · Methotrexate (1) · Methylprednisolone (1) · Omalizumab (1) · Prednisone (1) · salicylhydroxamic acid (1)
AstraZeneca (2) · Intersect ENT (2) · University Hospital, Ghent (2) · Allakos Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Intercommunal Creteil (1) · Dokuz Eylul University (1) · Medical University of Vienna (1) · Norwegian University of Science and Technology (1) · Optinose US Inc. (1) · Services Institute of Medical Sciences, Pakistan (1) · Tehran University of Medical Sciences (1) · University of Vermont Medical Center (1)
United States (7) · Belgium (5) · France (4) · Austria (2) · Germany (2) · Hungary (2) · Poland (2) · Turkey (Türkiye) (2) · Argentina (1) · Australia (1) · Bulgaria (1) · Canada (1) · Chile (1) · China (1) · Denmark (1)
Babak Saedi, professor (1) · Claus Bachert (1) · Claus Bachert, MD, PhD (1) · Claus Bachert, Prof. dr. h.c. (1) · Daniyal Babar (1) · Gary P Landrigan, MD (1) · Jennifer Carothers (1) · John Messina (1) · Jose P. Stolovitzky, MD (1) · Lars Jacob Stovner, md prof (1) · Luo Zhang, Prof. Dr. (1) · Paul Van Cauwenberge, PhD, MD (1) · Peter Manes, MD (1)
PMID 33710614, PMID 34110505, PMID 34599979, PMID 34633904, PMID 36549708
2015 (1), 2017 (1), 2023 (1)