2 completed, 1 suspended, 1 terminated. 4 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 2, Suspended 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
Follow MELAS: new trials by email Literature Review of MELAS trials Research Report on MELAS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD). Promoting Resilience in Stress Management (PRISM), Clinical-focused narrative (CFN) - Mitochondrial Diseases, Mitochondrial Myopathies | Phase 1 / Phase 2 | Completed | Children's Hospital of Philadelphia | 16 | 2023-09-22 | 2024-11-29 |
| The KHENERGYC Study Sonlicromanol, Placebo - Mitochondrial Diseases, Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation | Phase 2 | Suspended | Khondrion BV | 24 | 2021-02-01 | 2025-01-10 |
| Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) IW-6463 Tablets - MELAS | Phase 2 | Terminated | Tisento Therapeutics | 8 | 2020-11-13 | 2024-08-29 |
| The KHENERGY Study KH176, placebo - Mitochondrial Diseases, Mitochondrial Myopathies | Phase 2 | Completed | Khondrion BV | 20 | 2016-09-01 | 2018-02-23 |
MELAS Syndrome (4) · Mitochondrial Diseases (4) · Mitochondrial Encephalomyopathies (2) · Mitochondrial Myopathies (2) · Leigh Disease (1) · MERRF Syndrome (1)
Brain Diseases (4) · Brain Diseases, Metabolic (4) · Brain Diseases, Metabolic, Inborn (4) · Cardiovascular Diseases (4) · Central Nervous System Diseases (4) · Cerebral Small Vessel Diseases (4) · Cerebrovascular Disorders (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Genetic Diseases, Inborn (4) · Metabolic Diseases (4) · Metabolism, Inborn Errors (4) · Muscular Diseases (4) · Musculoskeletal Diseases (4) · Nervous System Diseases (4) · Neuromuscular Diseases (4)
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2)
Khondrion BV (2) · Children's Hospital of Philadelphia (1) · Tisento Therapeutics (1)
Netherlands (2) · United States (2)
Chad Glasser, PharmD (1) · Elizabeth M McCormick, MS (1) · Lonneke de Boer, MD (1)
U54NS078059 (1)