4 recruiting, 1 active not recruiting. 3 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Recruiting 2, Active not recruiting 1 |
| Phase 2 | 2 | Recruiting 2 |
Follow Locally Recurrent Head and Neck Squamous Cell Carcinoma: new trials by email Literature Review of Locally Recurrent Head and Neck Squamous Cell Carcinoma trials Research Report on Locally Recurrent Head and Neck Squamous Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer Biospecimen Collection, Carboplatin, Cemiplimab - Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 180 | 2026-04-24 | 2026-10-14 |
| Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell Carcinoma Losartan, Pembrolizumab, Stereotactic Body Radiation Therapy - Locally Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | University of California, Davis | 24 | 2023-12-07 | 2026-03-12 |
| BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study Biopsy Procedure, Biospecimen Collection, Cabozantinib S-malate - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 150 | 2022-12-06 | 2026-10-20 |
| Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer External Beam Radiation Therapy, Intraoperative Radiation Therapy, Pembrolizumab - Head and Neck Carcinoma of Unknown Primary, Locally Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 45 | 2022-05-12 | 2026-07-24 |
| Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma Biopsy Procedure, Birinapant, Computed Tomography - Locally Recurrent Head and Neck Squamous Cell Carcinoma, Nasopharyngeal Squamous Cell Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 13 | 2019-09-25 | 2026-08-03 |
Squamous Cell Carcinoma of Head and Neck (3) · Carcinoma (2) · Laryngeal Neoplasms (2) · Mouth Neoplasms (2) · Oropharyngeal Neoplasms (2) · Hypopharyngeal Neoplasms (1) · Melanoma (1)
Head and Neck Neoplasms (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Neoplasms by Site (4) · Neoplasms, Glandular and Epithelial (4) · Carcinoma, Squamous Cell (3) · Carcinoma (2) · Laryngeal Diseases (2) · Mouth Diseases (2) · Otorhinolaryngologic Diseases (2) · Otorhinolaryngologic Neoplasms (2) · Pharyngeal Diseases (2) · Pharyngeal Neoplasms (2) · Respiratory Tract Diseases (2) · Respiratory Tract Neoplasms (2)
Magnetic Resonance Spectroscopy (3) · Biopsy (2) · Radiation (2) · Radiotherapy (2) · Specimen Handling (2) · pembrolizumab (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · Carboplatin (1) · Cisplatin (1) · Losartan (1) · Nivolumab (1) · Paclitaxel (1) · Platinum (1) · Radiosurgery (1) · Radiotherapy, Intensity-Modulated (1)
National Cancer Institute (NCI) (3) · Ohio State University Comprehensive Cancer Center (1) · University of California, Davis (1)
United States (5)
Dukagjin M Blakaj, MD, PhD (1) · Nabil F Saba (1) · Shyam S.D. Rao, MD, PhD (1) · Siwen Hu-Lieskovan (1) · Vassiliki Saloura (1)
P30CA093373 (1), U10CA180868 (1), U10CA180888 (1)