3 completed, 2 terminated, 1 recruiting, 1 unknown. 7 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 3, Terminated 2, Recruiting 1, Unknown 1 |
| Phase 2 | 3 | Terminated 2, Completed 1 |
Follow Locally Advanced Rectal Cancer: new trials by email Literature Review of Locally Advanced Rectal Cancer trials Research Report on Locally Advanced Rectal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer Intensity-modulated radiation therapy, 5-fluorouracil, Leucovorin - Locally Advanced Rectal Cancer | Phase 1 | Recruiting | University of Miami | 25 | 2022-10-05 | 2026-02-06 |
| Total Neoadjuvant Treatment Plus PD-1 in Mid-Low Locally Advanced Rectal Cancer Sintilimab - Tislelizumab, Locally Advanced Rectal Cancer | Phase 1 | Unknown | The First Hospital of Jilin University | 46 | 2021-06-01 | 2023-11-18 |
| Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC Trial Trifluridine/tipiracil chemoradiation, Capecitabine based chemoradiation - Locally Advanced Rectal Cancer | Phase 1 / Phase 2 | Terminated | Universitätsklinikum Hamburg-Eppendorf | 10 | 2019-11-04 | 2023-02-22 |
| Chemoradiation With Enadenotucirev as a Radiosensitiser in Locally Advanced Rectal Cancer Enadenotucirev, Capecitabine, Radiotherapy - Locally Advanced Rectal Cancer | Phase 1 | Completed | University of Oxford | 12 | 2019-07-29 | 2025-02-06 |
| Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer Peposertib 50 mg, Peposertib 100 mg, Peposertib 150 mg - Locally Advanced Rectal Cancer | Phase 1 / Phase 2 | Completed | EMD Serono Research & Development Institute, Inc. | 19 | 2019-03-20 | 2023-03-21 |
| Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer IMRT - Locally Advanced Rectal Cancer | Phase 1 / Phase 2 | Terminated | Cancer Trials Ireland | 94 | 2014-10-17 | 2026-04-13 |
| A Clinical Study Conducted in Multiple Centers Evaluating Escalating Doses of Veliparib in Combination With Capecitabine and Radiation in Patients With Locally Advanced Rectal Cancer veliparib, capecitabine, radiation - Locally Advanced Rectal Cancer | Phase 1 | Completed | AbbVie (prior sponsor, Abbott) | 32 | 2012-06-01 | 2017-11-20 |
Rectal Neoplasms (2) · Adenoviridae Infections (1)
Colorectal Neoplasms (2) · Digestive System Diseases (2) · Digestive System Neoplasms (2) · Gastrointestinal Diseases (2) · Gastrointestinal Neoplasms (2) · Intestinal Diseases (2) · Intestinal Neoplasms (2) · Neoplasms (2) · Neoplasms by Site (2) · Rectal Diseases (2) · DNA Virus Infections (1) · Infections (1) · Virus Diseases (1)
Capecitabine (4) · Radiotherapy (2) · Fluorouracil (1) · Irinotecan (1) · Leucovorin (1) · Oxaliplatin (1) · Radiation (1) · Radiotherapy, Intensity-Modulated (1) · Trifluridine (1) · enadenotucirev (1) · peposertib (1) · sintilimab (1) · veliparib (1)
AbbVie (prior sponsor, Abbott) (1) · Cancer Trials Ireland (1) · EMD Serono Research & Development Institute, Inc. (1) · The First Hospital of Jilin University (1) · University of Miami (1) · University of Oxford (1) · Universitätsklinikum Hamburg-Eppendorf (1)
United States (3) · Australia (1) · China (1) · Germany (1) · Ireland (1) · Spain (1) · United Kingdom (1)
Alexander Stein (1) · Benjamin Spieler, MD (1) · Dr Brian O'Neill, MD (1) · Maria Hawkins, MD FRCR MRCP (1) · Philip Komarnitsky, MD (1)
PMID 28497757, PMID 32532291, PMID 32891715, PMID 39003182, PMID 39693793
2018 (1)