8 recruiting, 7 active not recruiting, 7 completed, 5 withdrawn. 17 Phase 2, 12 Phase 1, 4 Not applicable.
Follow Locally Advanced Malignant Solid Neoplasm: new trials by email Literature Review of Locally Advanced Malignant Solid Neoplasm trials Research Report on Locally Advanced Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adoption of Audio Recording in the Outpatient Supportive Care Center Communication Intervention, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm | Not yet recruiting | M.D. Anderson Cancer Center | 200 | 2026-12-30 | 2026-07-16 | |
| Exploratory Study on the Efficacy and Safety of Trastuzumab Rezetecan in the Treatment of HER2-Expressiong Advanced Solid Tumor Trastuzumab Rezetecan - Solid Tumors, Neoplasms (Cancer / Tumors) | Phase 2 | Not yet recruiting | Haihua Yuan | 15 | 2026-06-15 | 2026-06-08 |
| STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma Aldesleukin, Biopsy, Biospecimen Collection - Locally Advanced Cervical Carcinoma, Locally Advanced Colorectal Carcinoma | Phase 1 | Withdrawn | City of Hope Medical Center | 2025-12-05 | 2025-12-24 | |
| Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning Internet-Based Intervention, Best Practice, Telephone-Based Intervention - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 400 | 2025-02-18 | 2026-08-17 |
| Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors Azenosertib, Biopsy Procedure, Biospecimen Collection - Clinical Stage III Gastric Cancer AJCC v8, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 48 | 2025-02-03 | 2026-10-27 |
| Design and Testing of a Web-Based Tool for the Improvement of End-of-Life Planning in Patients With Advanced Cancer Best Practice, Internet-Based Intervention, Questionnaire Administration - Hematopoietic and Lymphoid System Neoplasm, Locally Advanced Malignant Solid Neoplasm | Not applicable | Completed | Fred Hutchinson Cancer Center | 100 | 2024-05-21 | 2026-10-02 |
| Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 33 | 2023-09-22 | 2026-08-24 |
| Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial Alpelisib, Binimetinib, Biopsy Procedure - Advanced Malignant Solid Neoplasm, Anatomic Stage III Breast Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 2900 | 2023-04-07 | 2026-11-02 |
| Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma Alpelisib, Carboplatin, Hyperpolarized Carbon-13 (13C) Pyruvate - Solid Tumors, Adult, PIK3CA Mutation-Related Tumors | Phase 1 | Withdrawn | Pamela Munster | 2022-11-01 | 2022-12-27 | |
| Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors Cyclophosphamide, Neoantigen Peptide Vaccine, Pembrolizumab - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 138 | 2022-03-31 | 2026-08-20 |
| BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors Copanlisib, Elimusertib - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Bone | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2022-03-22 | 2022-05-27 | |
| Assessment of Verbal Comprehension and Cognitive Processes in Patients Admitted to the Palliative and Supportive Care Unit Electroencephalography, Questionnaire Administration - Hematopoietic and Lymphoid Cell Neoplasm, Locally Advanced Malignant Solid Neoplasm | Suspended | M.D. Anderson Cancer Center | 30 | 2021-05-04 | 2026-10-06 | |
| Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors Larotrectinib Sulfate - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 13 | 2021-04-30 | 2026-10-07 |
| CMP-001 and INCAGN01949 for Patients With Stage IV Pancreatic Cancer and Other Cancers Except Melanoma Agonistic Anti-OX40 Monoclonal Antibody INCAGN01949, VLP-encapsulated TLR9 Agonist CMP-001 - Locally Advanced Malignant Solid Neoplasm, Metastatic Pancreatic Adenocarcinoma | Phase 1 / Phase 2 | Terminated | University of Southern California | 2 | 2021-04-29 | 2026-04-17 |
| Distress Associated with Coronavirus Disease 2019 and Telehealth on Supportive Care Patients with Advanced Cancer Survey Administration - Advanced Malignant Solid Neoplasm, COVID-19 Infection | Completed | M.D. Anderson Cancer Center | 223 | 2021-04-27 | 2024-09-19 | |
| Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations Biopsy Procedure, Biospecimen Collection, Computed Tomography - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 29 | 2021-04-26 | 2026-08-19 |
| Pevonedistat and Pembrolizumab for the Treatment of dMMR/MSI-H Metastatic or Locally Advanced Unresectable Solid Tumor Pembrolizumab, Pevonedistat - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 2 | 2021-03-29 | 2022-12-27 |
| Integrative Palliative Care/Psycho-Oncology Telehealth Intervention in Patients With Advanced Cancer Support Group Therapy, Symptom Management Service (SMS) Consultation, Quality of Life (QOL) Questionnaires - Advanced Malignant Solid Neoplasm, Locally Advanced Malignant Solid Neoplasm | Not applicable | Completed | University of California, San Francisco | 30 | 2021-01-26 | 2023-08-15 |
| Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors Avapritinib - Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 50 | 2021-01-20 | 2026-06-11 |
| PLAN Intervention to Enhance Engagement of Latino Cancer Patients in Advanced Care Planning Communication Intervention, Best Practice, Questionnaire Administration - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Not applicable | Completed | Fred Hutchinson Cancer Center | 27 | 2021-01-01 | 2025-09-09 |
Showing 20 of 32. Sign in to see all of them.
Neoplasm Metastasis (30) · Melanoma (6) · Hematologic Neoplasms (5) · Pancreatic Neoplasms (5) · Carcinoma, Renal Cell (4) · Endometrial Neoplasms (4) · Lung Neoplasms (4) · Carcinoma, Non-Small-Cell Lung (3) · Carcinoma, Transitional Cell (3) · Colorectal Neoplasms (3) · Neoplasms (3) · Stomach Neoplasms (3) · Uterine Cervical Neoplasms (3) · Carcinoma, Hepatocellular (2) · Ovarian Neoplasms (2)
Neoplastic Processes (30) · Pathologic Processes (30) · Pathological Conditions, Signs and Symptoms (30) · Neoplasms (28) · Neoplasms by Site (19) · Digestive System Diseases (10) · Digestive System Neoplasms (10) · Neoplasms by Histologic Type (10) · Urogenital Diseases (8) · Carcinoma (7) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Genital Diseases (7) · Neoplasms, Glandular and Epithelial (7) · Skin Diseases (7)
Specimen Handling (11) · Biopsy (10) · Magnetic Resonance Spectroscopy (8) · pembrolizumab (4) · Paclitaxel (3) · Practice Guidelines as Topic (3) · Standard of Care (3) · Taxes (3) · Alpelisib (2) · Carboplatin (2) · Cyclophosphamide (2) · Immunoglobulin G (2) · durvalumab (2) · ipatasertib (2) · olaparib (2)
M.D. Anderson Cancer Center (10) · National Cancer Institute (NCI) (10) · Fred Hutchinson Cancer Center (3) · Mayo Clinic (2) · City of Hope Medical Center (1) · Haihua Yuan (1) · Pamela Munster (1) · Rahul Aggarwal (1) · Sameek Roychowdhury (1) · University of California, San Francisco (1) · University of Southern California (1)
United States (28) · Puerto Rico (2)
A P Chen (2) · Megan J Shen, PhD (2) · Antoni Ribas (1) · David Hui (1) · David Hui, MD (1) · David S Hong (1) · Diana L Hanna, MD (1) · Funda Meric-Bernstam (1) · George R Blumenschein (1) · James M Ford (1) · Jordi Rodon Ahnert (1) · Kathryn Lurain (1) · Kristen R Spencer (1) · Megan J. Shen (1) · Michael J Overman (1)
PMID 31154457, PMID 33416261, PMID 35080914, PMID 36623241, PMID 38261444, PMID 38920407, PMID 39356983, PMID 39773433, PMID 41680482, PMID 41686845
U10CA180888 (2), F30CA250326 (1), K07CA207580 (1), P30CA014089 (1), P30CA015704 (1), P30CA016058 (1), P30CA033572 (1), R21CA197878 (1), R21NR016737 (1), R37CA246703 (1), R44NR020341 (1), U01CA154967 (1), U10CA032102 (1), U10CA180820 (1), U10CA180830 (1)