4 withdrawn, 2 active not recruiting, 2 completed, 2 recruiting. 12 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Withdrawn 4, Active not recruiting 2, Completed 2, Recruiting 2, Terminated 2 |
| Phase 2 | 5 | Terminated 2, Active not recruiting 1, Completed 1, Recruiting 1 |
Follow Locally Advanced Malignant Solid Neoplasm: new trials by email Literature Review of Locally Advanced Malignant Solid Neoplasm trials Research Report on Locally Advanced Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma Aldesleukin, Biopsy, Biospecimen Collection - Locally Advanced Cervical Carcinoma, Locally Advanced Colorectal Carcinoma | Phase 1 | Withdrawn | City of Hope Medical Center | 2025-12-05 | 2025-12-24 | |
| Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors Azenosertib, Biopsy Procedure, Biospecimen Collection - Clinical Stage III Gastric Cancer AJCC v8, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 48 | 2025-02-03 | 2026-10-27 |
| Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma Alpelisib, Carboplatin, Hyperpolarized Carbon-13 (13C) Pyruvate - Solid Tumors, Adult, PIK3CA Mutation-Related Tumors | Phase 1 | Withdrawn | Pamela Munster | 2022-11-01 | 2022-12-27 | |
| Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors Cyclophosphamide, Neoantigen Peptide Vaccine, Pembrolizumab - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 138 | 2022-03-31 | 2026-08-20 |
| BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors Copanlisib, Elimusertib - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Bone | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2022-03-22 | 2022-05-27 | |
| CMP-001 and INCAGN01949 for Patients With Stage IV Pancreatic Cancer and Other Cancers Except Melanoma Agonistic Anti-OX40 Monoclonal Antibody INCAGN01949, VLP-encapsulated TLR9 Agonist CMP-001 - Locally Advanced Malignant Solid Neoplasm, Metastatic Pancreatic Adenocarcinoma | Phase 1 / Phase 2 | Terminated | University of Southern California | 2 | 2021-04-29 | 2026-04-17 |
| Pevonedistat and Pembrolizumab for the Treatment of dMMR/MSI-H Metastatic or Locally Advanced Unresectable Solid Tumor Pembrolizumab, Pevonedistat - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 2 | 2021-03-29 | 2022-12-27 |
| Testing the Safety of CB-5339 in Patients With Cancer p97 Inhibitor CB-5339 Tosylate - Aggressive Non-Hodgkin Lymphoma, Indolent Non-Hodgkin Lymphoma | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2020-06-18 | 2025-09-17 | |
| Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies Avelumab, Biopsy Procedure, Biospecimen Collection - Locally Advanced Malignant Solid Neoplasm, Locally Advanced Unresectable Cholangiocarcinoma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 103 | 2020-04-07 | 2026-10-02 |
| Ceritinib and Everolimus in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIB-IV Non-small Cell Lung Cancer Ceritinib, Everolimus, Laboratory Biomarker Analysis - ALK Positive, Locally Advanced Malignant Solid Neoplasm | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 37 | 2016-06-22 | 2026-05-20 |
| Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer Antiretroviral Therapy, Biopsy, Biospecimen Collection - AIDS-Related Non-Hodgkin Lymphoma, Clinical Stage III Cutaneous Melanoma AJCC v8 | Phase 1 | Completed | National Cancer Institute (NCI) | 58 | 2016-04-04 | 2024-08-09 |
| Uprosertib, Dabrafenib, and Trametinib in Treating Patients With Stage IIIC-IV Cancer Biopsy, Biospecimen Collection, Computed Tomography - Hematopoietic and Lymphoid Cell Neoplasm, Locally Advanced Malignant Solid Neoplasm | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 27 | 2013-10-08 | 2025-01-14 |
Neoplasm Metastasis (11) · Melanoma (4) · Carcinoma, Hepatocellular (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Renal Cell (2) · Lung Neoplasms (2) · Pancreatic Neoplasms (2) · Uterine Cervical Neoplasms (2) · Carcinoma, Lobular (1) · Carcinoma, Merkel Cell (1) · Carcinoma, Transitional Cell (1) · Carcinosarcoma (1) · Cholangiocarcinoma (1) · Colorectal Neoplasms (1) · Endometrial Neoplasms (1)
Neoplasms (11) · Neoplastic Processes (11) · Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Neoplasms by Site (7) · Digestive System Diseases (6) · Digestive System Neoplasms (6) · Neoplasms by Histologic Type (5) · Adenocarcinoma (4) · Carcinoma (4) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Neuroectodermal Tumors (4) · Neuroendocrine Tumors (4)
Biopsy (6) · Specimen Handling (6) · Magnetic Resonance Spectroscopy (5) · pembrolizumab (3) · Cyclophosphamide (2) · Alpelisib (1) · Antiretroviral Therapy, Highly Active (1) · BAY 1895344 (1) · CYT003-QbG10 (1) · Carboplatin (1) · Colony-Stimulating Factors (1) · Everolimus (1) · GSK2141795 (1) · Immunoglobulin G (1) · Pyruvic Acid (1)
National Cancer Institute (NCI) (5) · M.D. Anderson Cancer Center (3) · City of Hope Medical Center (1) · Mayo Clinic (1) · Pamela Munster (1) · University of Southern California (1)
United States (9)
Antoni Ribas (1) · Diana L Hanna, MD (1) · Funda Meric-Bernstam (1) · George R Blumenschein (1) · Kathryn Lurain (1) · Kristen R Spencer (1) · Michael J Overman (1) · Naoko Takebe (1) · Pamela Munster, MD (1) · Timothy A Yap, MD (1) · Vincent Chung (1) · Yanyan Lou, MD, PhD (1)
PMID 31154457, PMID 35080914, PMID 38261444, PMID 39356983, PMID 41680482
P30CA014089 (1), P30CA015704 (1), P30CA033572 (1), U01CA154967 (1), U10CA032102 (1), U10CA180830 (1), U10CA180888 (1), UM1CA186644 (1), UM1CA186688 (1), UM1CA186716 (1)